RAET1E Recombinant Protein

Name: RAET1E Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205119
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205119

RAET1E belongs to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. RAET1E and RAET1G protein differ from other RAET1 proteins in that they have type I… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RAET1E, Recombinant Protein

Full Product Name

RAET1E, 31-225aa, Human, His tag, E Coli (Denatured)

Product Gene Name

RAET1E recombinant protein

Product Synonym Names

NKG2D ligand 4; bA350J20.7; LETAL; N2DL-4; NKG2DL4; RAET1E2; RL-4; uLBP4

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMHSLCFN FTIKSLSRPG QPWCEAQVFL NKNLFLQYNS DNNMVKPLGL LGKKVYATST WGELTQTLGE VGRDLRMLLC DIKPQIKTSD PSTLQVEMFC QREAERCTGA SWQFATNGEK SLLFDAMNMT WTVINHEASK IKETWKKDRG LEKYFRKLSK GDCDHWLREF LGHWEAMPEP TVSPVNASDI HWSSSSLPD

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

24.9 kDa (219aa)

OMIM

AY069961 mRNA

3D Structure

ModBase 3D Structure for Q8TD07

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for RAET1E recombinant protein

Immunology

Applications Tested/Suitable for RAET1E recombinant protein

SDS-PAGE

Application Notes for RAET1E recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for RAET1E recombinant protein

McGilvray,R.W., et al. (2010) Int. J. Cancer 127 (6), 1412-1420; Antoun,A., et al. (2010) Hum. Immunol. 71 (6), 610-620;

Other Notes

Small volumes of RAET1E recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAET1E purchase

MBS205119 is a recombinant protein targeting RAET1E. Also known as RAET1E, 31-225aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for RAET1E. It may not necessarily be applicable to this product.

NCBI GI #

21040249

NCBI GeneID

135250

NCBI Accession #

NP_631904

UniProt Primary Accession #

Q8TD07

UniProt Secondary Accession #

Q5VYB7; Q5VYB8; Q8TEZ2; Q96L41; A6YF59

UniProt Related Accession #

Q8TD07

GenBank Nucleotide #

NM_139165.2

NCBI Official Full Name

retinoic acid early transcript 1E isoform 1

NCBI Official Synonym Full Names

retinoic acid early transcript 1E

NCBI Official Symbol

RAET1E

NCBI Official Synonym Symbols

RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7

UniProt Protein Name

Retinoic acid early transcript 1E

UniProt Synonym Protein Names

Lymphocyte effector toxicity activation ligand

Protein Family

NKG2D ligand

UniProt Gene Name

RAET1E

UniProt Synonym Gene Names

N2DL-4; NKG2DL4

NCBI Protein Information

retinoic acid early transcript 1E; NKG2D ligand 4

NCBI Summary for RAET1E

This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

UniProt Comments for RAET1E

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Research Articles on RAET1E

1. Blocking the interaction of NKG2D with its ligands deleted the sensitizing effects of HCQ. In addition, we showed that HCQ did not affect the synthesis or degradation of ULBP4, but induced the translocation of ULBP4 from the cytoplasm to the cell membrane

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RAET1E recombinant protein

Reference Product	PubMed Publications
KLRK1 recombinant protein	>20 publications with RAET1E and KLRK1
RAET1G recombinant protein	>10 publications with RAET1E and RAET1G
RAET1L recombinant protein	>6 publications with RAET1E and RAET1L

Pathways associated with RAET1E recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Natural Killer Cell Mediated Cytotoxicity Pathway antibodies	Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Natural Killer Cell Mediated Cytotoxicity Pathway antibodies	Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with RAET1E recombinant protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>2 publications with RAET1E and Immune System Diseases
Atherosclerosis Antibodies	>2 publications with RAET1E and Atherosclerosis
Arteriosclerosis Antibodies	>2 publications with RAET1E and Arteriosclerosis
Cardiovascular Diseases Antibodies	>2 publications with RAET1E and Cardiovascular Diseases
Metaplasia Antibodies	>1 publications with RAET1E and Metaplasia
Liver Diseases Antibodies	>1 publications with RAET1E and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with RAET1E and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with RAET1E and Liver Neoplasms
Inflammation Antibodies	>1 publications with RAET1E and Inflammation
Necrosis Antibodies	>1 publications with RAET1E and Necrosis

Organs/Tissues associated with RAET1E recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with RAET1E and Brain
Liver Antibodies	>2 publications with RAET1E and Liver
Skin Antibodies	>1 publications with RAET1E and Skin
Cervix Antibodies	>1 publications with RAET1E and Cervix