Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Antibody – Rabbit Polyclonal

ENTPD1: an ectonucleotidase that, like CD73, hydrolyzes immunostimulatory ATP, and ADP, to immunosuppressive AMP. May inhibit host immune responses against cancer. Expressed at high levels in malignant epithelial cells of human rectal adenocarcinoma. A prognostic marker of chronic lymphocytic leukemia that may identify patients with an unfavorable clinical outcome. Synergizes with CD161 to modulate Th17 responses in Crohn's disease. It may hydrolyze ATP and other nucleotides in the nervous system to regulate purinergic neurotransmission in the nervous system. May be implicated in inhibiting platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. Belongs to the GDA1/CD39 NTPase family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.5; Extracellular matrix; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 1q54

Cellular Component: basal lamina; basolateral plasma membrane; cell soma; cell surface; extracellular space; membrane; neuron projection; postsynaptic density; synaptic vesicle

Molecular Function: adenosine-diphosphatase activity; ATPase activity; identical protein binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of dopamine secretion; platelet activation; protein homooligomerization; purine ribonucleoside diphosphate catabolic process; response to ATP; response to caffeine; response to gamma radiation; response to lipopolysaccharide; response to morphine; response to proline