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SAR1B Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205183

SAR1b, also known as CMRD, is involved in transport from the endoplasmic reticulum to the Golgi apparatus. This protein is activated by the guanine nucleotide exchange factor PREB. It is involved in the selection of the protein cargo and the assembly of the… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SAR1B, Recombinant Protein
Full Product Name
SAR1B, 1-198aa, Human, His tag, E Coli
Product Gene Name
SAR1B recombinant protein
Product Synonym Names
GTP-binding protein SAR1b; ANDD; CMRD; GTBPB; SARA2
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSFIFDW IYSGFSSVLQ FLGLYKKTGK LVFLGLDNAG KTTLLHMLKD DRLGQHVPTL HPTSEELTIA GMTFTTFDLG GHVQARRVWK NYLPAINGIV FLVDCADHER LLESKEELDS LMTDETIANV PILILGNKID RPEAISEERL REMFGLYGQT TGKGSISLKE LNARPLEVFM CSVLKRQGYG EGFRWMAQYI D
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol
Purity/Purification
> 95% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
24.8kDa (221aa), confirmed by MALDI-TOF
OMIM
AF092130 mRNA
3D Structure
ModBase 3D Structure for Q9Y6B6
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for SAR1B recombinant protein

Signal Transduction
Applications Tested/Suitable for SAR1B recombinant protein
SDS-PAGE

SDS-Page of SAR1B recombinant protein

SAR1B Recombinant Protein – Cat# MBS205183

Product References and Citations for SAR1B recombinant protein

Annesi G., et al. (2007) Clin. Genet. 71:288-289; Treepongkaruna S., et al. (2009) J. Pediatr. Gastroenterol. Nutr. 48:370-373

Other Notes

Small volumes of SAR1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SAR1B purchase

MBS205183 is a recombinant protein targeting SAR1B. Also known as SAR1B, 1-198aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SAR1B. It may not necessarily be applicable to this product.

NCBI GI #
7705827
NCBI GeneID
51128
NCBI Accession #
NP_057187
UniProt Primary Accession #
Q9Y6B6
UniProt Secondary Accession #
Q567T4; D3DQA4
UniProt Related Accession #
Q9Y6B6
GenBank Nucleotide #
NM_016103.3
NCBI Official Full Name
GTP-binding protein SAR1b
NCBI Official Synonym Full Names
secretion associated Ras related GTPase 1B
NCBI Official Symbol
SAR1B
NCBI Official Synonym Symbols
ANDD; CMRD; GTBPB; SARA2
UniProt Protein Name
GTP-binding protein SAR1b
UniProt Synonym Protein Names
GTP-binding protein B; GTBPB
Protein Family
GTP-binding protein
UniProt Gene Name
SAR1B
UniProt Synonym Gene Names
SARA2; SARB; GTBPB
NCBI Protein Information
GTP-binding protein SAR1b

NCBI Summary for SAR1B

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
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UniProt Comments for SAR1B

Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.

Research Articles on SAR1B

1. Report compensatory Sar1a elevation after Sar1b gene deletion in Caco-2/15 cells prevents chylomicron collapse.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SAR1B recombinant protein

 Reference Product  PubMed Publications
 SEC13 recombinant protein  >7 publications with SAR1B and SEC13
 SEC23A recombinant protein  >5 publications with SAR1B and SEC23A
 SEC24C recombinant protein  >1 publications with SAR1B and SEC24C

Pathways associated with SAR1B recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 COPII Complex Pathway antibodies  COPII Complex Pathway Diagram
 COPII Complex Pathway antibodies  COPII Complex Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram

Diseases associated with SAR1B recombinant protein

 Disease Name  Pubmed Publications
 Chylomicron retention disease Antibodies  >23 publications with SAR1B and Chylomicron retention disease
 Dyslipidemias Antibodies  >18 publications with SAR1B and Dyslipidemias
 Diarrhea Antibodies  >6 publications with SAR1B and Diarrhea
 Fatty Liver Antibodies  >4 publications with SAR1B and Fatty Liver
 Abnormalities, Multiple Antibodies  >2 publications with SAR1B and Abnormalities, Multiple
 Cognition Disorders Antibodies  >1 publications with SAR1B and Cognition Disorders
 Heart Defects, Congenital Antibodies  >1 publications with SAR1B and Heart Defects, Congenital
 Ataxia Antibodies  >1 publications with SAR1B and Ataxia
 Atrophy Antibodies  >1 publications with SAR1B and Atrophy
 Heart Diseases Antibodies  >1 publications with SAR1B and Heart Diseases

Organs/Tissues associated with SAR1B recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >15 publications with SAR1B and Intestine
 Liver Antibodies  >10 publications with SAR1B and Liver
 Blood Antibodies  >9 publications with SAR1B and Blood
 Heart Antibodies  >5 publications with SAR1B and Heart
 Bone Antibodies  >5 publications with SAR1B and Bone
 Brain Antibodies  >4 publications with SAR1B and Brain
 Muscle Antibodies  >3 publications with SAR1B and Muscle
 Pancreas Antibodies  >2 publications with SAR1B and Pancreas
 Lung Antibodies  >2 publications with SAR1B and Lung
 Vascular Antibodies  >2 publications with SAR1B and Vascular
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