Erythropoietin (EPO) Human Recombinant Protein

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

Isolation and characterization of genomic and cDNA clones of human erythropoietin.Jacobs K., Shoemaker C., Rudersdorf R., Neill S.D., Kaufman R.J., Mufson A., Seehra J., Jones S.S., Hewick R., Fritsch E.F., Kawakita M., Shimizu T., Miyake T.Nature 313:806-810(1985) Cloning and expression of the human erythropoietin gene.Lin F.-K., Suggs S., Lin C.-H., Browne J.K., Smalling R., Egrie J.C., Chen K.K., Fox G.M., Martin F., Stabinsky Z., Badrawi S.M., Lai P.-H., Goldwasser E.Proc. Natl. Acad. Sci. U.S.A. 82:7580-7584(1985) Large-scale sequencing of two regions in human chromosome 7q22 analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.Gloeckner G., Scherer S., Schattevoy R., Boright A.P., Weber J., Tsui L.-C., Rosenthal A.Genome Res. 8:1060-1073(1998) Erythropoietin gene sequence in the Quechua, a high altitude native population.Rupert J.L., Hochachka P.W.The DNA sequence of human chromosome 7.Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.Nature 424:157-164(2003) Gene expression of mutant erythropoietin in hepatocellular carcinoma.Funakoshi A., Muta H., Baba T., Shimizu S.Biochem. Biophys. Res. Commun. 195:717-722(1993) Structural characterization of human erythropoietin.Lai P.H., Everett R., Wang F.F., Arakawa T., Goldwasser E.J. Biol. Chem. 261:3116-3121(1986) Isolation of human erythropoietin with monoclonal antibodies.Yanagawa S., Hirade K., Ohnota H., Sasaki R., Chiba H., Ueda M., Goto M.J. Biol. Chem. 259:2707-2710(1984) Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells.Takeuchi M., Takasaki S., Miyazaki H., Kato T., Hoshi S., Kochibe N., Kobata A.J. Biol. Chem. 263:3657-3663(1988) Site-specific glycosylation of human recombinant erythropoietin analysis of glycopeptides or peptides at each glycosylation site by fast atom bombardment mass spectrometry.Sasaki H., Ochi N., Dell A., Fukuda M.Biochemistry 27:8618-8626(1988) Structures and functional roles of the sugar chains of human erythropoietins.Takeuchi M., Kobata A.Glycobiology 1:337-346(1991) Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietin.Skibeli V., Nissen-Lie G., Torjesen P.Blood 98:3626-3634(2001) Efficiency of signalling through cytokine receptors depends critically on receptor orientation.Syed R.S., Reid S.W., Li C., Cheetham J.C., Aoki K.H., Liu B., Zhan H., Osslund T.D., Chirino A.J., Zhang J., Finer-Moore J., Elliott S., Sitney K., Katz B.A., Matthews D.J., Wendoloski J.J., Egrie J., Stroud R.M.Nature 395:511-516(1998) NMR structure of human erythropoietin and a comparison with its receptor bound conformation.Cheetham J.C., Smith D.M., Aoki K.H., Stevenson J.L., Hoeffel T.J., Syed R.S., Egrie J., Harvey T.S.Nat. Struct. Biol. 5:861-866(1998) Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.Genetics of diabetes and diabetic complication study groupTong Z., Yang Z., Patel S., Chen H., Gibbs D., Yang X., Hau V.S., Kaminoh Y., Harmon J., Pearson E., Buehler J., Chen Y., Yu B., Tinkham N.H., Zabriskie N.A., Zeng J., Luo L., Sun J.K., Prakash M., Hamam R.N., Tonna S., Constantine R., Ronquillo C.C., Sadda S., Avery R.L., Brand J.M., London N., Anduze A.L., King G.L., Bernstein P.S., Watkins S., Jorde L.B., Li D.Y., Aiello L.P., Pollak M.R., Zhang K.Proc. Natl. Acad. Sci. U.S.A. 105:6998-7003(2008)

Small volumes of EPO recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS965903 is a recombinant protein targeting EPO. Also known as Recombinant Human Erythropoietin.