DHH (C23II) (DHH) Recombinant Protein

DHH is a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. Recombinant human DHH protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Chen YJ, et al. (2007). Cell Cycle. 6 (15):1826-30.; Van den Brink GR., et al. (2007). Physiol Rev. 87 (4):1343-75

Small volumes of DHH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS205313 is a recombinant protein targeting DHH. Also known as Desert hedgehog protein. Host: E Coli.