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PPP1R11 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205325

Protein phosphatase 1 regulatory subunit 11, also known as PPP1R11, is a 126 amino acid protein that is expressed in a variety of both adult and fetal tissues. PPP1R11 functions as an inhibitor of PP1 (protein phosphatase 1), specifically exhibiting a… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PPP1R11, Recombinant Protein
Full Product Name
PPP1R11, 1-126aa, Human, His tag, E Coli
Product Synonym Names
Protein phosphatase 1 regulatory subunit 11; HCG-V; HCGV; IPP3; TCTE5; TCTEX5
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAEAGAG LSETVTETTV TVTTEPENRS LTIKLRKRKP EKKVEWTSDT VDNEHMGRRS SKCCCIYEKP RAFGESSTES DEEEEEGCGH THCVRGHRKG RRRATLGPTP TTPPQPPDPS QPPPGPMQH
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol, 1mM DTT
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.25mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
16.3kDa (149aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
OMIM
X81003 mRNA
3D Structure
ModBase 3D Structure for O60927
Antigen Species
Human
Tag Information
His-tag
Applications Tested/Suitable for PPP1R11 recombinant protein
SDS-PAGE

Product References and Citations for PPP1R11 recombinant protein

Giffon T., et al. (1996) Immunogenrtics. 44:331-339; Zhang J., et al. (1998) Biochemistry. 37:16728-16734.

Other Notes

Small volumes of PPP1R11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP1R11 purchase

MBS205325 is a recombinant protein targeting PPP1R11. Also known as PPP1R11, 1-126aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP1R11. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
E3 ubiquitin-protein ligase PPP1R11
NCBI Official Synonym Full Names
protein phosphatase 1 regulatory inhibitor subunit 11
NCBI Official Symbol
PPP1R11
NCBI Official Synonym Symbols
HCGV; IPP3; HCG-V; TCTE5; TCTEX5; CFAP255
UniProt Protein Name
E3 ubiquitin-protein ligase PPP1R11
UniProt Synonym Protein Names
Hemochromatosis candidate gene V protein; HCG V; Protein phosphatase 1 regulatory subunit 11; Protein phosphatase inhibitor 3
UniProt Gene Name
PPP1R11
UniProt Synonym Gene Names
HCGV; TCTE5; HCG V
NCBI Protein Information
E3 ubiquitin-protein ligase PPP1R11; protein phosphatase 1 regulatory subunit 11

NCBI Summary for PPP1R11

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

UniProt Comments for PPP1R11

Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPP1R11 recombinant protein

 Reference Product  PubMed Publications
 PPP1R7 recombinant protein  >3 publications with PPP1R11 and PPP1R7
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