CENPM Recombinant Protein

Name: CENPM Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205339
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205339

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CENPM, Recombinant Protein

Full Product Name

CENPM, 1-180aa, Human, His tag, E Coli

Product Gene Name

CENPM recombinant protein

Product Synonym Names

Centromere protein M isoform a; bK250D10.2; C22orf18; CENP-M; PANE1

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSVLRPL DKLPGLNTAT ILLVGTEDAL LQQLADSMLK EDCASELKVH LAKSLPLPSS VNRPRIDLIV FVVNLHSKYS LQNTEESLRH VDASFFLGKV CFLATGAGRE SHCSIHRHTV VKLAHTYQSP LLYCDLEVEG FRATMAQRLV RVLQICAGHV PGVSALNLLS LLRSSEGPSL EDL

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT.

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

22 kDa (203aa), confirmed by MALDI-TOF

OMIM

EU035297 mRNA

3D Structure

ModBase 3D Structure for Q9NSP4

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for CENPM recombinant protein

Epigenomics

Applications Tested/Suitable for CENPM recombinant protein

SDS-PAGE

Product References and Citations for CENPM recombinant protein

Brickner AG, Evans AM, et al. (2006). Blood. 107 (9):3779-86. ; Bierie B, Edwin M, et al. (2004). Gene Expr Patterns. 4 (4):389-95.

Other Notes

Small volumes of CENPM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CENPM purchase

MBS205339 is a recombinant protein targeting CENPM. Also known as CENPM, 1-180aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CENPM. It may not necessarily be applicable to this product.

NCBI GI #

13129022

NCBI GeneID

79019

NCBI Accession #

NP_076958

UniProt Primary Accession #

Q9NSP4

UniProt Secondary Accession #

Q6I9W3; A7LM22; B1AHQ9

UniProt Related Accession #

Q9NSP4

GenBank Nucleotide #

NM_024053.4

NCBI Official Full Name

centromere protein M isoform a

NCBI Official Synonym Full Names

centromere protein M

NCBI Official Symbol

CENPM

NCBI Official Synonym Symbols

PANE1; CENP-M; C22orf18

UniProt Protein Name

Centromere protein M

UniProt Synonym Protein Names

Interphase centromere complex protein 39; Proliferation-associated nuclear element protein 1

Protein Family

Centromere protein

UniProt Gene Name

CENPM

UniProt Synonym Gene Names

C22orf18; ICEN39; PANE1; CENP-M

NCBI Protein Information

centromere protein M

NCBI Summary for CENPM

The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

UniProt Comments for CENPM

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

Research Articles on CENPM

1. CENP-M is crucially required for the assembly and stability of a tetramer also comprising CENP-I, CENP-H, and CENP-K, the HIKM complex, which we extensively characterize through a combination of structural, biochemical, and cell biological approaches.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CENPM recombinant protein

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Chromosome Maintenance Pathway antibodies	Chromosome Maintenance Pathway Diagram
Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies	Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
M Phase Pathway antibodies	M Phase Pathway Diagram
Mitotic Anaphase Pathway antibodies	Mitotic Anaphase Pathway Diagram
Mitotic Metaphase And Anaphase Pathway antibodies	Mitotic Metaphase And Anaphase Pathway Diagram
Mitotic Prometaphase Pathway antibodies	Mitotic Prometaphase Pathway Diagram
Nucleosome Assembly Pathway antibodies	Nucleosome Assembly Pathway Diagram
RHO GTPase Effectors Pathway antibodies	RHO GTPase Effectors Pathway Diagram

Diseases associated with CENPM recombinant protein

Disease Name	Pubmed Publications
Carcinoma, Hepatocellular Antibodies	>1 publications with CENPM and Carcinoma, Hepatocellular