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CNOT8 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205356

CNOT8 belongs to the CAF1 family. It is a ubiquitous transcription factor required for a diverse set of processes and functions as part of the CCR-NOT complex. The CCR4-NOT complex functions as general transcription regulation complex. This complex contains… More details

$245 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNOT8, Recombinant Protein
Full Product Name
CNOT8, 1-292aa, Human, His tag, E Coli
Product Gene Name
CNOT8 recombinant protein
Product Synonym Names
CCR4-NOT transcription complex subunit 8; CAF1; CALIF; hCAF1; POP2
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPAALVE NSQVICEVWA SNLEEEMRKI REIVLSYSYI AMDTEFPGVV VRPIGEFRSS IDYQYQLLRC NVDLLKIIQL GLTFTNEKGE YPSGINTWQF NFKFNLTEDM YSQDSIDLLA NSGLQFQKHE EEGIDTLHFA ELLMTSGVVL CDNVKWLSFH SGYDFGYMVK LLTDSRLPEE EHEFFHILNL FFPSIYDVKY LMKSCKNLKG GLQEVADQLD LQRIGRQHQA GSDSLLTGMA FFRMKELFFE DSIDDAKYCG RLYGLGTGVA QKQNEDVDSA QEKMSILAII NNMQQ
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.25 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
35.9 kDa (315aa), confirmed by MALDI-TOF
OMIM
AF053318 mRNA
3D Structure
ModBase 3D Structure for Q9UFF9
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for CNOT8 recombinant protein

Epigenomics
Applications Tested/Suitable for CNOT8 recombinant protein
SDS-PAGE

SDS-Page of CNOT8 recombinant protein

CNOT8 Recombinant Protein – Cat# MBS205356

Product References and Citations for CNOT8 recombinant protein

Morel A.-P., et al. (2003) J. Cell Sci. 116:2929-2936; Albert T.K., et al. (2000) Nucleic Acids Res. 28:809-817

Other Notes

Small volumes of CNOT8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNOT8 purchase

MBS205356 is a recombinant protein targeting CNOT8. Also known as CNOT8, 1-292aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CNOT8. It may not necessarily be applicable to this product.

NCBI GI #
31542315
NCBI GeneID
9337
NCBI Accession #
NP_004770
UniProt Primary Accession #
Q9UFF9
UniProt Secondary Accession #
O95709; Q7Z521; Q9H6Y1; B0AZS3; B2RAR8; B7Z8R1; D3DQI8
UniProt Related Accession #
Q9UFF9
GenBank Nucleotide #
NM_004779.5
NCBI Official Full Name
CCR4-NOT transcription complex subunit 8 isoform 1
NCBI Official Synonym Full Names
CCR4-NOT transcription complex subunit 8
NCBI Official Symbol
CNOT8
NCBI Official Synonym Symbols
CAF1; POP2; CALIF; Caf1b; hCAF1
UniProt Protein Name
CCR4-NOT transcription complex subunit 8
UniProt Synonym Protein Names
CAF1-like protein; CALIFp; CAF2; CCR4-associated factor 8; Caf1b
Protein Family
CCR4-NOT transcription complex
UniProt Gene Name
CNOT8
UniProt Synonym Gene Names
CALIF; POP2; CALIFp
NCBI Protein Information
CCR4-NOT transcription complex subunit 8

UniProt Comments for CNOT8

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
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Research Articles on CNOT8

1. These results indicate that Caf1 and Ccr4 cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 and Ccr4 are regulated via allosteric interactions within the nuclease module.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CNOT8 recombinant protein

 Reference Product  PubMed Publications
 CNOT1 recombinant protein  >10 publications with CNOT8 and CNOT1
 TOB1 recombinant protein  >8 publications with CNOT8 and TOB1
 BTG2 recombinant protein  >8 publications with CNOT8 and BTG2
 CNOT6L recombinant protein  >7 publications with CNOT8 and CNOT6L
 CNOT6 recombinant protein  >7 publications with CNOT8 and CNOT6
 CNOT3 recombinant protein  >4 publications with CNOT8 and CNOT3
 PABPC1 recombinant protein  >3 publications with CNOT8 and PABPC1
 CNOT2 recombinant protein  >2 publications with CNOT8 and CNOT2
 CNOT4 recombinant protein  >1 publications with CNOT8 and CNOT4

Pathways associated with CNOT8 recombinant protein

 Products by Pathway  Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 TP53 Regulates Transcription Of Cell Cycle Genes Pathway antibodies  TP53 Regulates Transcription Of Cell Cycle Genes Pathway Diagram
 TP53 Regulates Transcription Of Additional Cell Cycle Genes Whose Exact Role In The P53 Pathway Remain Uncertain antibodies  TP53 Regulates Transcription Of Additional Cell Cycle Genes Whose Exact Role In The P53 Pathway Remain Uncertain Diagram
 Transcriptional Regulation By TP53 Pathway antibodies  Transcriptional Regulation By TP53 Pathway Diagram

Diseases associated with CNOT8 recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with CNOT8 and Breast Neoplasms
 Necrosis Antibodies  >3 publications with CNOT8 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >2 publications with CNOT8 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >2 publications with CNOT8 and Inflammation
 Disease Models, Animal Antibodies  >1 publications with CNOT8 and Disease Models, Animal

Organs/Tissues associated with CNOT8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with CNOT8 and Brain
 Blood Antibodies  >2 publications with CNOT8 and Blood
 Nerve Antibodies  >2 publications with CNOT8 and Nerve
 Kidney Antibodies  >1 publications with CNOT8 and Kidney
 Embryonic Tissue Antibodies  >1 publications with CNOT8 and Embryonic Tissue
 Eye Antibodies  >1 publications with CNOT8 and Eye
 Vascular Antibodies  >1 publications with CNOT8 and Vascular
 Muscle Antibodies  >1 publications with CNOT8 and Muscle
 Lymph Antibodies  >1 publications with CNOT8 and Lymph
 Mouth Antibodies  >1 publications with CNOT8 and Mouth
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