IMPAD1 Recombinant Protein

Name: IMPAD1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205390
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205390

Inositol monophosphatase 3, also known as IMPAD1, is a member of the inositol monophosphatase family. IMPAD1 is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IMPAD1, Recombinant Protein

Full Product Name

IMPAD1, 34-359aa, Human, His tag, E Coli (Denatured)

Product Gene Name

IMPAD1 recombinant protein

Product Synonym Names

Inositol monophosphatase 3; GPAPP; IMP 3; IMP-3; IMPA3

Sequence

MGSSHHHHHH SSGLVPRGSH MGSGRFSLFG LGGEPGGGAA GPAAAADGGT VDLREMLAVS VLAAVRGGDE VRRVRESNVL HEKSKGKTRE GAEDKMTSGD VLSNRKMFYL LKTAFPSVQI NTEEHVDAAD QEVILWDHKI PEDILKEVTT PKEVPAESVT VWIDPLDATQ EYTEDLRKYV TTMVCVAVNG KPMLGVIHKP FSEYTAWAMV DGGSNVKARS SYNEKTPRIV VSRSHSGMVK QVALQTFGNQ TTIIPAGGAG YKVLALLDVP DKSQEKADLY IHVTYIKKWD ICAGNAILKA LGGHMTTLSG EEISYTGSDG IEGGLLASIR MNHQALVRKL PDLEKTGHK

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 2M urea, 20% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

37.6kDa (349aa)

OMIM

AK000428 mRNA

3D Structure

ModBase 3D Structure for Q9NX62

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for IMPAD1 recombinant protein

Metabolism

Applications Tested/Suitable for IMPAD1 recombinant protein

SDS-PAGE

Application Notes for IMPAD1 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for IMPAD1 recombinant protein

Vissers L E., et al. (2011) Am J Hum Genet. 88 (5):608-15.; Kalujnaia S., et al. (2010) FASEB J. 24 (10):3981-91.

Other Notes

Small volumes of IMPAD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IMPAD1 purchase

MBS205390 is a recombinant protein targeting IMPAD1. Also known as IMPAD1, 34-359aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IMPAD1. It may not necessarily be applicable to this product.

NCBI GI #

157388900

NCBI GeneID

54928

NCBI Accession #

NP_060283

UniProt Primary Accession #

Q9NX62

UniProt Secondary Accession #

Q6NVY7

UniProt Related Accession #

Q9NX62

GenBank Nucleotide #

NM_017813.4

NCBI Official Full Name

inositol monophosphatase 3

NCBI Official Synonym Full Names

inositol monophosphatase domain containing 1

NCBI Official Symbol

IMPAD1

NCBI Official Synonym Symbols

GPAPP; IMP 3; IMP-3; IMPA3

UniProt Protein Name

Inositol monophosphatase 3

UniProt Synonym Protein Names

Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Golgi-resident PAP phosphatase; gPAPP; Inositol monophosphatase domain-containing protein 1; Inositol-1(or 4)-monophosphatase 3; Myo-inositol monophosphatase A3

Protein Family

Inositol monophosphatase

UniProt Gene Name

IMPAD1

UniProt Synonym Gene Names

IMPA3; IMP 3; IMPase 3; Golgi-resident PAP phosphatase; gPAPP

NCBI Protein Information

inositol monophosphatase 3

NCBI Summary for IMPAD1

This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, Dec 2011]

UniProt Comments for IMPAD1

May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.

Research Articles on IMPAD1

1. concluded that IMPAD1 should be screened for patients with Catel-Manzke and additional features

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IMPAD1 recombinant protein

Products by Pathway	Pathway Diagram
D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies	D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies	D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
Inositol Phosphate Metabolism Pathway antibodies	Inositol Phosphate Metabolism Pathway Diagram
Inositol Phosphate Metabolism Pathway antibodies	Inositol Phosphate Metabolism Pathway Diagram
Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies	Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies	Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Phosphatidylinositol Signaling System Pathway antibodies	Phosphatidylinositol Signaling System Pathway Diagram
Phosphatidylinositol Signaling System Pathway antibodies	Phosphatidylinositol Signaling System Pathway Diagram
Sulfur Metabolism Pathway antibodies	Sulfur Metabolism Pathway Diagram

Diseases associated with IMPAD1 recombinant protein

Disease Name	Pubmed Publications
CHONDRODYSPLASIA WITH JOINT DISLOCATIONS, GPAPP TYPE Antibodies	>1 publications with IMPAD1 and CHONDRODYSPLASIA WITH JOINT DISLOCATIONS, GPAPP TYPE

Organs/Tissues associated with IMPAD1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>1 publications with IMPAD1 and Bone