PGPEP1 Recombinant Protein

Name: PGPEP1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205423
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205423

PGPEP1 is an omega peptidase which removes pyroglutamyl residues from the amino termini of peptides and proteins. It is a cytosolic cysteine peptidase that is expressed in most cell types. The enzyme requires a thiolreducing agent for activity. PGPEP1 is… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PGPEP1, Recombinant Protein

Full Product Name

PGPEP1, 1-209aa, Human, His tag, E Coli

Product Gene Name

PGPEP1 recombinant protein

Product Synonym Names

Pyroglutamyl-peptidase 1; Pyroglutamyl-peptidase I; Pcp; PGP; PGP-I; PGPI

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMEQPRKA VVVTGFGPFG EHTVNASWIA VQELEKLGLG DSVDLHVYEI PVEYQTVQRL IPALWEKHSP QLVVHVGVSG MATTVTLEKC GHNKGYKGLD NCRFCPGSQC CVEDGPESID SIIDMDAVCK RVTTLGLDVS VTISQDAGRY LCDFTYYTSL YQSHGRSAFV HVPPLGKPYN ADQLGRALRA IIEEMLDLLE QSEGKINYCH KH

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 2-8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Molecular Weight

25.5 kDa (232aa), confirmed by MALDI-TOF

OMIM

AJ278828 mRNA

3D Structure

ModBase 3D Structure for Q9NXJ5

Tag Information

His-tag

Product Categories/Family for PGPEP1 recombinant protein

Proteases & Inhibitors

Applications Tested/Suitable for PGPEP1 recombinant protein

SDS-PAGE

Product References and Citations for PGPEP1 recombinant protein

Kilbane Z. et al. (2007) Mol. Cell. Biochem. 297:189.

Other Notes

Small volumes of PGPEP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGPEP1 purchase

MBS205423 is a recombinant protein targeting PGPEP1. Also known as PGPEP1, 1-209aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PGPEP1. It may not necessarily be applicable to this product.

NCBI GI #

8923198

NCBI GeneID

54858

NCBI Accession #

NP_060182

UniProt Primary Accession #

Q9NXJ5

UniProt Secondary Accession #

Q8IVT1; A8K1Q3

UniProt Related Accession #

Q9NXJ5

GenBank Nucleotide #

NM_017712.3

NCBI Official Full Name

pyroglutamyl-peptidase 1 isoform 1

NCBI Official Synonym Full Names

pyroglutamyl-peptidase I

NCBI Official Symbol

PGPEP1

NCBI Official Synonym Symbols

PGI; PGP; Pcp; PGPI; PAP-I; PGP-I

UniProt Protein Name

Pyroglutamyl-peptidase 1

UniProt Synonym Protein Names

5-oxoprolyl-peptidase; Pyroglutamyl aminopeptidase I; PAP-I; Pyroglutamyl-peptidase I; PGP-I; Pyrrolidone-carboxylate peptidase

Protein Family

Pyroglutamyl-peptidase

UniProt Gene Name

PGPEP1

UniProt Synonym Gene Names

PGPI; PAP-I; PGP-I

NCBI Protein Information

pyroglutamyl-peptidase 1

NCBI Summary for PGPEP1

The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]

UniProt Comments for PGPEP1

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Research Articles on PGPEP1

1. cytosolic peptidases(puromycin-sensitive aminopeptidase (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) ) may be involved in colorectal carcinogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with PGPEP1 recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>1 publications with PGPEP1 and Disease Models, Animal

Organs/Tissues associated with PGPEP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>1 publications with PGPEP1 and Intestine
Brain Antibodies	>1 publications with PGPEP1 and Brain