Arachidonate-15-Lipoxygenase, Type B (ALOX15B) Antibody – Rabbit Polyclonal

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ALOX15B: Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized. Belongs to the lipoxygenase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell cycle regulation; EC 1.13.11.33; Lipid Metabolism - arachidonic acid; Motility/polarity/chemotaxis; Oxidoreductase

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm; cytoskeleton; cytosol; extrinsic to membrane; intracellular; membrane; plasma membrane

Molecular Function: arachidonate 15-lipoxygenase activity; calcium ion binding; iron ion binding; lipoxygenase activity

Biological Process: apoptosis; arachidonic acid metabolic process; hepoxilin biosynthetic process; lipid metabolic process; lipoxygenase pathway; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of growth