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MXD3 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205470

MXD3 is a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MXD3, Recombinant Protein
Full Product Name
MXD3, 1-206aa, Human, His tag, E Coli (Denatured)
Product Gene Name
Product Synonym Names
Max dimerization protein 3; BHLHC13; MAD3; MYX
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEPLASN IQVLLQAAEF LERREREAEH GYASLCPHRS PGPIHRRKKR PPQAPGAQDS GRSVHNELEK RRRAQLKRCL ERLKQQMPLG ADCARYTTLS LLRRARMHIQ KLEDQEQRAR QLKERLRSKQ QSLQRQLEQL RGLAGAAERE RLRADSLDSS GLSSERSDSD QEELEVDVES LVFGGEAELL RGFVAGQEHS YSHGGGAWL
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
25.9 kDa (229aa)
OMIM
AF114834 mRNA
3D Structure
ModBase 3D Structure for Q9BW11
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for MXD3 recombinant protein

Applications Tested/Suitable for MXD3 recombinant protein
SDS-PAGE
Application Notes for MXD3 recombinant protein
This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for MXD3 recombinant protein

Yun JS, Rust JM, et al. (2007). Mol Cell Biol. 27 (23):8178-89.; Barisone GA, Yun JS, et al. (2008). Cell Cycle. 7 (4):423-7.

Other Notes

Small volumes of MXD3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MXD3 purchase

MBS205470 is a recombinant protein targeting MXD3. Also known as MXD3, 1-206aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MXD3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
max dimerization protein 3 isoform a
NCBI Official Synonym Full Names
MAX dimerization protein 3
NCBI Official Symbol
MXD3
NCBI Official Synonym Symbols
MYX; MAD3; BHLHC13
UniProt Protein Name
Max dimerization protein 3
UniProt Synonym Protein Names
Class C basic helix-loop-helix protein 13; bHLHc13; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; Myx
UniProt Gene Name
MXD3
UniProt Synonym Gene Names
BHLHC13; MAD3; Max dimerizer 3; bHLHc13
NCBI Protein Information
max dimerization protein 3

NCBI Summary for MXD3

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
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UniProt Comments for MXD3

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation ().

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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