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BCCIP Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205525

BCCIP was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain,… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BCCIP, Recombinant Protein
Full Product Name
BCCIP, 1-314aa, Human, His tag, E Coli
Product Gene Name
BCCIP recombinant protein
Product Synonym Names
BRCA2 and CDKN1A interacting protein; TOK-1; TOK1
Sequence
MGSSHHHHHH SSGLVPRGSH MGSEFMASRS KRRAVESGVP QPPDPPVQRD EEEEKEVENE DEDDDDSDKE KDEEDEVIDE EVNIEFEAYS LSDNDYDGIK KLLQQLFLKA PVNTAELTDL LIQQNHIGSV IKQTDVSEDS NDDMDEDEVF GFISLLNLTE RKGTQCVEQI QELVLRFCEK NCEKSMVEQL DKFLNDTTKP VGLLLSERFI NVPPQIALPM YQQLQKELAG AHRTNKPCGK CYFYLLISKT FVEAGKNNSK KKPSNKKKAA LMFANAEEEF FYEKAILKFN YSVQEESDTC LGGKWSFDDV PMTPLRTVML IPGDKMNEIM DKLKEYLSV
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
38.6kDa (339aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
OMIM
AB040450 mRNA
3D Structure
ModBase 3D Structure for Q9P287
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for BCCIP recombinant protein

Cell Cycle
Applications Tested/Suitable for BCCIP recombinant protein
SDS-PAGE

SDS-Page of BCCIP recombinant protein

BCCIP Recombinant Protein – Cat# MBS205525

Product References and Citations for BCCIP recombinant protein

Luedeke,M., et al. (2009) Cancer Epidemiol. Biomarkers Prev. 18 (11), 3030-3035; Fan,J., et al. (2009) Cell Cycle 8 (18), 3019-3024;

Other Notes

Small volumes of BCCIP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCCIP purchase

MBS205525 is a recombinant protein targeting BCCIP. Also known as BCCIP, 1-314aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BCCIP. It may not necessarily be applicable to this product.

NCBI GI #
17402871
NCBI GeneID
56647
NCBI Accession #
NP_510868
UniProt Primary Accession #
Q9P287
UniProt Secondary Accession #
Q8ND15; Q96GC4; Q9P288; B3KP45
UniProt Related Accession #
Q9P287
GenBank Nucleotide #
NM_078468.2
NCBI Official Full Name
BRCA2 and CDKN1A-interacting protein isoform BCCIPbeta
NCBI Official Synonym Full Names
BRCA2 and CDKN1A interacting protein
NCBI Official Symbol
BCCIP
NCBI Official Synonym Symbols
TOK1; TOK-1
UniProt Protein Name
BRCA2 and CDKN1A-interacting protein
UniProt Synonym Protein Names
P21- and CDK-associated protein 1; Protein TOK-1
Protein Family
BRCA2 and CDKN1A-interacting protein
UniProt Gene Name
BCCIP
UniProt Synonym Gene Names
TOK1
NCBI Protein Information
BRCA2 and CDKN1A-interacting protein

NCBI Summary for BCCIP

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for BCCIP

During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
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Research Articles on BCCIP

1. this study identifies BCCIP as a novel factor critical for microtubule regulation and explicates a mechanism utilized by BCCIP in tumor suppression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BCCIP recombinant protein

 Reference Product  PubMed Publications
 CDK2 recombinant protein  >3 publications with BCCIP and CDK2
 CCNH recombinant protein  >1 publications with BCCIP and CCNH

Diseases associated with BCCIP recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >5 publications with BCCIP and Breast Neoplasms
 Adenocarcinoma Antibodies  >4 publications with BCCIP and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >3 publications with BCCIP and Carcinoma, Hepatocellular
 Nervous System Diseases Antibodies  >3 publications with BCCIP and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with BCCIP and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >2 publications with BCCIP and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with BCCIP and Liver Neoplasms
 Uterine Cervical Neoplasms Antibodies  >1 publications with BCCIP and Uterine Cervical Neoplasms
 Intestinal Neoplasms Antibodies  >1 publications with BCCIP and Intestinal Neoplasms
 Kidney Diseases Antibodies  >1 publications with BCCIP and Kidney Diseases

Organs/Tissues associated with BCCIP recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with BCCIP and Liver
 Prostate Antibodies  >2 publications with BCCIP and Prostate
 Kidney Antibodies  >2 publications with BCCIP and Kidney
 Brain Antibodies  >2 publications with BCCIP and Brain
 Lung Antibodies  >1 publications with BCCIP and Lung
 Embryonic Tissue Antibodies  >1 publications with BCCIP and Embryonic Tissue
 Uterus Antibodies  >1 publications with BCCIP and Uterus
 Testis Antibodies  >1 publications with BCCIP and Testis
 Mammary Gland Antibodies  >1 publications with BCCIP and Mammary Gland
 Skin Antibodies  >1 publications with BCCIP and Skin
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