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M6PR Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205536

M6PR is a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. This protein functions as a homodimer… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
M6PR, Recombinant Protein
Full Product Name
M6PR, 27-185aa, Human, His tag, E Coli
Product Gene Name
Product Synonym Names
Cation-dependent mannose-6-phosphate receptor isoform 1; CD-MPR; MPR 46; MPR-46; MPR46; SMPR
Sequence
MGSSHHHHHH SSGLVPRGSH MGSTEEKTCD LVGEKGKESE KELALVKRLK PLFNKSFEST VGQGSDTYIY IFRVCREAGN HTSGAGLVQI NKSNGKETVV GRLNETHIFN GSNWIMLIYK GGDEYDNHCG KEQRRAVVMI SCNRHTLADN FNPVSEERGK VQDCFYLFEM DSSLACSPEI SH
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Purity/Purification
> 85% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 2°C to 8°C for one week.
For long term storage, aliquot and store at -20°C to -80°C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
20.3kDa (182aa) confirmed by MALDI-TOF
OMIM
M16985 mRNA
3D Structure
ModBase 3D Structure for P20645
Domain
27-185aa
Tags
His-Tag

Product Categories/Family for M6PR recombinant protein

Applications Tested/Suitable for M6PR recombinant protein
SDS-PAGE

SDS-Page of M6PR recombinant protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
M6PR Recombinant Protein – Cat# MBS205536

Product References and Citations for M6PR recombinant protein

Prabakaran T, Nielsen R., et al. (2012) PLoS One. 2012;7 (6):e39975.

Other Notes

Small volumes of M6PR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for M6PR purchase

MBS205536 is a recombinant protein targeting M6PR. Also known as M6PR, 27-185aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for M6PR. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cation-dependent mannose-6-phosphate receptor isoform 1
NCBI Official Synonym Full Names
mannose-6-phosphate receptor, cation dependent
NCBI Official Symbol
M6PR
NCBI Official Synonym Symbols
SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR
UniProt Protein Name
Cation-dependent mannose-6-phosphate receptor
UniProt Synonym Protein Names
46 kDa mannose 6-phosphate receptor; MPR 46
UniProt Gene Name
M6PR
UniProt Synonym Gene Names
MPR46; MPRD; CD Man-6-P receptor; CD-MPR; MPR 46
NCBI Protein Information
cation-dependent mannose-6-phosphate receptor

NCBI Summary for M6PR

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
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UniProt Comments for M6PR

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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