LMX1B Recombinant Protein

Name: LMX1B Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205563
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205563

LMX1B is a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LMX1B, Recombinant Protein

Full Product Name

LMX1B, 1-395aa, Human, His tag, E Coli (Denatured)

Product Gene Name

LMX1B recombinant protein

Product Synonym Names

LIM homeobox transcription factor 1-beta isoform 1; LIM homeobox transcription factor 1 beta; LMX1.2; NPS1

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMDIATGP ESLERCFPRG QTDCAKMLDG IKMEEHALRP GPATLGVLLG SDCPHPAVCE GCQRPISDRF LMRVNESSWH EECLQCAACQ QALTTSCYFR DRKLYCKQDY QQLFAAKCSG CMEKIAPTEF VMRALECVYH LGCFCCCVCE RQLRKGDEFV LKEGQLLCKG DYEKEKDLLS SVSPDESDSV KSEDEDGDMK PAKGQGSQSK GSGDDGKDPR RPKRPRTILT TQQRRAFKAS FEVSSKPCRK VRETLAAETG LSVRVVQVWF QNQRAKMKKL ARRHQQQQEQ QNSQRLGQEV LSSRMEGMMA SYTPLAPPQQ QIVAMEQSPY GSSDPFQQGL TPPQMPGNDS IFHDIDSDTS LTSLSDCFLG SSDVGSLQAR VGNPIDRLYS MQSSYFAS

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Purity/Purification

> 80% by SDS-PAGE

Concentration

1.0 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

46.5 kDa (418 aa)

3D Structure

ModBase 3D Structure for O60663

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for LMX1B recombinant protein

Neuroscience

Applications Tested/Suitable for LMX1B recombinant protein

SDS-PAGE

Application Notes for LMX1B recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for LMX1B recombinant protein

Vollrath D., Jaramillo-babb V L., et al. (1998). Hum. Mol. Genet. 7:1091-1098

Other Notes

Small volumes of LMX1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LMX1B purchase

MBS205563 is a recombinant protein targeting LMX1B. Also known as LMX1B, 1-395aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LMX1B. It may not necessarily be applicable to this product.

NCBI GI #

292494911

NCBI GeneID

4010

NCBI Accession #

NP_002307

UniProt Primary Accession #

O60663

UniProt Secondary Accession #

O75463; Q5JU95; Q6ISC9; F8W7W6

UniProt Related Accession #

O60663

GenBank Nucleotide #

NM_002316.3

NCBI Official Full Name

LIM homeobox transcription factor 1-beta isoform 1

NCBI Official Synonym Full Names

LIM homeobox transcription factor 1 beta

NCBI Official Symbol

LMX1B

NCBI Official Synonym Symbols

NPS1; LMX1.2

UniProt Protein Name

LIM homeobox transcription factor 1-beta

UniProt Synonym Protein Names

LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B

Protein Family

LIM/homeobox protein

UniProt Gene Name

LMX1B

UniProt Synonym Gene Names

LMX-1.2

NCBI Protein Information

LIM homeobox transcription factor 1-beta

NCBI Summary for LMX1B

This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

UniProt Comments for LMX1B

Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.

Research Articles on LMX1B

1. 9q33.3q34.11 microdeletion including LMX1b gene identified in four patients with intellectual disability, epilepsy, nail dysplasia and bone malformations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LMX1B recombinant protein

Reference Product	PubMed Publications
FGF8 recombinant protein	>18 publications with LMX1B and FGF8
LDB1 recombinant protein	>10 publications with LMX1B and LDB1
MEIS2 recombinant protein	>1 publications with LMX1B and MEIS2

Pathways associated with LMX1B recombinant protein

Products by Pathway	Pathway Diagram
Dopaminergic Neurogenesis Pathway antibodies	Dopaminergic Neurogenesis Pathway Diagram
Primary Focal Segmental Glomerulosclerosis FSGS Pathway antibodies	Primary Focal Segmental Glomerulosclerosis FSGS Pathway Diagram
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways antibodies	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways Diagram

Diseases associated with LMX1B recombinant protein

Disease Name	Pubmed Publications
Nail-Patella Syndrome Antibodies	>93 publications with LMX1B and Nail-Patella Syndrome
Congenital Abnormalities Antibodies	>83 publications with LMX1B and Congenital Abnormalities
Congenital, Hereditary, and Neonatal Diseases and Abnormalities Antibodies	>83 publications with LMX1B and Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Kidney Diseases Antibodies	>36 publications with LMX1B and Kidney Diseases
Movement Disorders Antibodies	>18 publications with LMX1B and Movement Disorders
Proteinuria Antibodies	>16 publications with LMX1B and Proteinuria
Mental Disorders Antibodies	>10 publications with LMX1B and Mental Disorders
Renal Insufficiency Antibodies	>8 publications with LMX1B and Renal Insufficiency
Hypertension Antibodies	>8 publications with LMX1B and Hypertension
Hematuria Antibodies	>6 publications with LMX1B and Hematuria

Organs/Tissues associated with LMX1B recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>103 publications with LMX1B and Brain
Eye Antibodies	>25 publications with LMX1B and Eye
Mixed Antibodies	>2 publications with LMX1B and Mixed
Testis Antibodies	>1 publications with LMX1B and Testis