MMP8 Recombinant Protein

Name: MMP8 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205583
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205583

MMP8 protein of the matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MMP8, Recombinant Protein

Full Product Name

MMP8, 101- 467aa, Human, His tag, E Coli (Denatured)

Product Gene Name

MMP8 recombinant protein

Product Synonym Names

neutrophil collagenase preproprotein; CLG1; HNC; MMP-8; PMNL-CL

Sequence

MGSSHHHHHH SSGLVPRGSH MGSLTPGNPK WERTNLTYRI RNYTPQLSEA EVERAIKDAF ELWSVASPLI FTRISQGEAD INIAFYQRDH GDNSPFDGPN GILAHAFQPG QGIGGDAHFD AEETWTNTSA NYNLFLVAAH EFGHSLGLAH SSDPGALMYP NYAFRETSNY SLPQDDIDGI QAIYGLSSNP IQPTGPSTPK PCDPSLTFDA ITTLRGEILF FKDRYFWRRH PQLQRVEMNF ISLFWPSLPT GIQAAYEDFD RDLIFLFKGN QYWALSGYDI LQGYPKDISN YGFPSSVQAI DAAVFYRSKT YFFVNDQFWR YDNQRQFMEP GYPKSISGAF PGIESKVDAV FQQEHFFHVF SGPRYYAFDL IAQRVTRVAR GNKWLNCRYG

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Purity/Purification

> 85% by SDS-PAGE

Concentration

1mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

44.3 kDa (390aa)

OMIM

J05556 mRNA

3D Structure

ModBase 3D Structure for P22894

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for MMP8 recombinant protein

Cancer

Applications Tested/Suitable for MMP8 recombinant protein

SDS-PAGE

Application Notes for MMP8 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for MMP8 recombinant protein

Hasty K.A., et al (1990). J. Biol. Chem. 265:11421-11424; Betz M., et al (1997). Eur. J. Biochem. 247:356-363;

Other Notes

Small volumes of MMP8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP8 purchase

MBS205583 is a recombinant protein targeting MMP8. Also known as MMP8, 101- 467aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP8. It may not necessarily be applicable to this product.

NCBI GI #

4505221

NCBI GeneID

4317

NCBI Accession #

NP_002415

UniProt Primary Accession #

P22894

UniProt Secondary Accession #

Q45F99

UniProt Related Accession #

P22894

GenBank Nucleotide #

NM_002424.2

NCBI Official Full Name

neutrophil collagenase isoform 1 preproprotein

NCBI Official Synonym Full Names

matrix metallopeptidase 8

NCBI Official Symbol

MMP8

NCBI Official Synonym Symbols

HNC; CLG1; MMP-8; PMNL-CL

UniProt Protein Name

Neutrophil collagenase

UniProt Synonym Protein Names

Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL

Protein Family

Neutrophil collagenase

UniProt Gene Name

MMP8

UniProt Synonym Gene Names

CLG1; MMP-8; PMNL-CL

NCBI Protein Information

neutrophil collagenase

NCBI Summary for MMP8

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

UniProt Comments for MMP8

Can degrade fibrillar type I, II, and III collagens.

Research Articles on MMP8

1. Data show that individuals with MMP-8 -799TT genotype and intermediate HIV disease stage are at higher risk for the advancement of HIV disease. MMP-8 polymorphism indicated a trend of elevated risk for the modulation of HIV-associated neurocognitive disorder (HAND) severity. MMP-8 -799TT genotype may facilitate the risk for the development of HAND with tobacco and alcohol usage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MMP8 recombinant protein

Reference Product	PubMed Publications
TIMP1 recombinant protein	>50 publications with MMP8 and TIMP1
TIMP2 recombinant protein	>19 publications with MMP8 and TIMP2
ELANE recombinant protein	>2 publications with MMP8 and ELANE

Pathways associated with MMP8 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram
Neutrophil Degranulation Pathway antibodies	Neutrophil Degranulation Pathway Diagram

Diseases associated with MMP8 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>142 publications with MMP8 and Inflammation
Cardiovascular Diseases Antibodies	>63 publications with MMP8 and Cardiovascular Diseases
Fibrosis Antibodies	>37 publications with MMP8 and Fibrosis
Disease Models, Animal Antibodies	>36 publications with MMP8 and Disease Models, Animal
Necrosis Antibodies	>34 publications with MMP8 and Necrosis
Lung Diseases Antibodies	>31 publications with MMP8 and Lung Diseases
Heart Diseases Antibodies	>23 publications with MMP8 and Heart Diseases
Hemorrhage Antibodies	>19 publications with MMP8 and Hemorrhage
Wounds and Injuries Antibodies	>18 publications with MMP8 and Wounds and Injuries
Death Antibodies	>17 publications with MMP8 and Death

Organs/Tissues associated with MMP8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>150 publications with MMP8 and Blood
Connective Tissue Antibodies	>23 publications with MMP8 and Connective Tissue
Skin Antibodies	>19 publications with MMP8 and Skin
Liver Antibodies	>15 publications with MMP8 and Liver
Bone Marrow Antibodies	>11 publications with MMP8 and Bone Marrow
Thymus Antibodies	>1 publications with MMP8 and Thymus