MX2 Recombinant Protein

Name: MX2 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205632
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205632

MX2 has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MX2, Recombinant Protein

Full Product Name

MX2, 626-715aa, Human, His tag, E Coli (Denatured)

Product Gene Name

MX2 recombinant protein

Product Synonym Names

Myxovirus resistance protein 2; MXB

Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSIGIH LNAYFLETSK RLANQIPFII QYFMLRENGD SLQKAMMQIL QEKNRYSWLL QEQSETATKR RILKERIYRL TQARHALCQF SSKEIH

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

14.9 kDa (126aa)

OMIM

M30818 mRNA

3D Structure

ModBase 3D Structure for P20592

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for MX2 recombinant protein

Immunology

Applications Tested/Suitable for MX2 recombinant protein

SDS-PAGE

Application Notes for MX2 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for MX2 recombinant protein

Melen K, Keskinen P, et al. (1996). J Biol Chem. 271 (38):23478-86.; al-Masri AN, Werfel T, et al. (1997). Mol Pathol. 50 (1):9-14.;

Other Notes

Small volumes of MX2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MX2 purchase

MBS205632 is a recombinant protein targeting MX2. Also known as MX2, 626-715aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MX2. It may not necessarily be applicable to this product.

NCBI GI #

11342664

NCBI GeneID

4600

NCBI Accession #

NP_002454.1

UniProt Primary Accession #

P20592

UniProt Secondary Accession #

B7Z5D3; D3DSI7

UniProt Related Accession #

P20592

GenBank Nucleotide #

NM_002463.1

NCBI Official Full Name

interferon-induced GTP-binding protein Mx2

NCBI Official Synonym Full Names

MX dynamin like GTPase 2

NCBI Official Symbol

MX2

NCBI Official Synonym Symbols

MXB

UniProt Protein Name

Interferon-induced GTP-binding protein Mx2

UniProt Synonym Protein Names

Interferon-regulated resistance GTP-binding protein MxB; Myxovirus resistance protein 2; p78-related protein

Protein Family

Interferon-induced GTP-binding protein

UniProt Gene Name

MX2

NCBI Protein Information

interferon-induced GTP-binding protein Mx2

NCBI Summary for MX2

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

UniProt Comments for MX2

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.

Research Articles on MX2

1. MxB dimers form higher order oligomers that restrict retroviral replication by binding to the viral capsid. [review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MX2 recombinant protein

Reference Product	PubMed Publications
ISG15 recombinant protein	>36 publications with MX2 and ISG15
OAS1 recombinant protein	>19 publications with MX2 and OAS1
IRF7 recombinant protein	>13 publications with MX2 and IRF7
RSAD2 recombinant protein	>11 publications with MX2 and RSAD2
IFIT1 recombinant protein	>9 publications with MX2 and IFIT1
OAS2 recombinant protein	>7 publications with MX2 and OAS2
IFIT3 recombinant protein	>6 publications with MX2 and IFIT3
OASL recombinant protein	>2 publications with MX2 and OASL
HERC5 recombinant protein	>1 publications with MX2 and HERC5
OAS3 recombinant protein	>1 publications with MX2 and OAS3

Pathways associated with MX2 recombinant protein

Products by Pathway	Pathway Diagram
Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies	Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
ISG15 Antiviral Mechanism Pathway antibodies	ISG15 Antiviral Mechanism Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram
Interferon Alpha/beta Signaling Pathway antibodies	Interferon Alpha/beta Signaling Pathway Diagram

Diseases associated with MX2 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>39 publications with MX2 and Nervous System Diseases
Disease Models, Animal Antibodies	>20 publications with MX2 and Disease Models, Animal
Influenza, Human Antibodies	>20 publications with MX2 and Influenza, Human
Inflammation Antibodies	>19 publications with MX2 and Inflammation
Neoplasms, Experimental Antibodies	>19 publications with MX2 and Neoplasms, Experimental
Necrosis Antibodies	>18 publications with MX2 and Necrosis
Lung Diseases Antibodies	>14 publications with MX2 and Lung Diseases
Adenocarcinoma Antibodies	>11 publications with MX2 and Adenocarcinoma
Lung Neoplasms Antibodies	>10 publications with MX2 and Lung Neoplasms
Liver Diseases Antibodies	>10 publications with MX2 and Liver Diseases

Organs/Tissues associated with MX2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>96 publications with MX2 and Blood
Brain Antibodies	>33 publications with MX2 and Brain
Lung Antibodies	>23 publications with MX2 and Lung
Liver Antibodies	>17 publications with MX2 and Liver
Uterus Antibodies	>16 publications with MX2 and Uterus
Skin Antibodies	>16 publications with MX2 and Skin
Vascular Antibodies	>10 publications with MX2 and Vascular
Bone Antibodies	>10 publications with MX2 and Bone
Heart Antibodies	>10 publications with MX2 and Heart
Spleen Antibodies	>9 publications with MX2 and Spleen