STRADA Recombinant Protein

Name: STRADA Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205660
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205660

STE20-related kinase adapter protein alpha isoform 5, also known as STRADA, is a member of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. It functions as an upstream activator of LKB1 and also directs the… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

STRADA, Recombinant Protein

Full Product Name

STRADA, 1-314aa, Human, His tag, E Coli (Denatured)

Product Gene Name

STRADA recombinant protein

Product Synonym Names

STE20-related kinase adapter protein alpha isoform 5; LYK5; NY-BR-96; PMSE; Stlk; STRAD

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSFLVSK PERIRTNDAS SESIASFSKQ EVMSSFLPEG GCYELLTVIG KGFEDLMTVN LARYKPTGEY VTVRRINLEA CSNEMVTFLQ GELHVSKLFN HPNIVPYRAT FIADNELWVV TSFMAYGSAK DLICTHFMDG MNELAIAYIL QGVLKALDYI HHMGYVHRSV KASHILISVD GKVYLSGLRS NLSMISHGQR QRVVHDFPKY SVKVLPWLSP EVLQQNLQGY DAKSDIYSVG ITACELANGH VPFKDMPATQ MLLEKLNGTV PCLLDTSTIP AEELTMSPSR SVANSGLSDS LTTSTPRPSN GPVPAPS

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

37 kDa (337aa)

OMIM

AF308302 mRNA

3D Structure

ModBase 3D Structure for Q7RTN6

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for STRADA recombinant protein

Cell Cycle

Applications Tested/Suitable for STRADA recombinant protein

SDS-PAGE

Application Notes for STRADA recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for STRADA recombinant protein

Avizienyte E., et al. (1998) Cancer Res. 58: 2087-2090.; Baas A F., et al. (2003) EMBO J. 22: 3062-3072.

Other Notes

Small volumes of STRADA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STRADA purchase

MBS205660 is a recombinant protein targeting STRADA. Also known as STRADA, 1-314aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for STRADA. It may not necessarily be applicable to this product.

NCBI GI #

260166664

NCBI GeneID

92335

NCBI Accession #

NP_001159441

UniProt Primary Accession #

Q7RTN6

UniProt Secondary Accession #

Q5JPI2; Q7Z4K9; Q8NC31; Q8NCF1; Q9H272; B4DDE3; B4DW17; J3KTC9

UniProt Related Accession #

Q7RTN6

GenBank Nucleotide #

NM_001165969.1

NCBI Official Full Name

STE20-related kinase adapter protein alpha isoform 5

NCBI Official Synonym Full Names

STE20-related kinase adaptor alpha

NCBI Official Symbol

STRADA

NCBI Official Synonym Symbols

LYK5; PMSE; Stlk; STRAD; NY-BR-96

UniProt Protein Name

STE20-related kinase adapter protein alpha

UniProt Synonym Protein Names

STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96

Protein Family

STE20-related kinase adapter protein

UniProt Gene Name

STRADA

UniProt Synonym Gene Names

; STRAD alpha

NCBI Protein Information

STE20-related kinase adapter protein alpha

NCBI Summary for STRADA

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

UniProt Comments for STRADA

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Research Articles on STRADA

1. We identified for the first time a homozygous point mutation in STRADA causing PMSE. Additional bi-allelic mutations related to PMSE thus far have not been observed in Baylor approximately 6,000 consecutive clinical WES cases, supporting the rarity of this disorder.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with STRADA recombinant protein

Reference Product	PubMed Publications
STK11 recombinant protein	>1 publications with STRADA and STK11

Pathways associated with STRADA recombinant protein

Products by Pathway	Pathway Diagram
AMP-activated Protein Kinase (AMPK) Signaling Pathway antibodies	AMP-activated Protein Kinase (AMPK) Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies	Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
IGF1R Signaling Cascade Pathway antibodies	IGF1R Signaling Cascade Pathway Diagram
IRS-mediated Signalling Pathway antibodies	IRS-mediated Signalling Pathway Diagram
IRS-related Events Triggered By IGF1R Pathway antibodies	IRS-related Events Triggered By IGF1R Pathway Diagram
Insulin Receptor Signalling Cascade Pathway antibodies	Insulin Receptor Signalling Cascade Pathway Diagram
LKB1 Signaling Events Pathway antibodies	LKB1 Signaling Events Pathway Diagram
PI3K Cascade Pathway antibodies	PI3K Cascade Pathway Diagram

Diseases associated with STRADA recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>216 publications with STRADA and Nervous System Diseases
Cardiovascular Diseases Antibodies	>158 publications with STRADA and Cardiovascular Diseases
Vascular Diseases Antibodies	>133 publications with STRADA and Vascular Diseases
Inflammation Antibodies	>96 publications with STRADA and Inflammation
Liver Diseases Antibodies	>62 publications with STRADA and Liver Diseases
Neoplasm Metastasis Antibodies	>44 publications with STRADA and Neoplasm Metastasis
Necrosis Antibodies	>44 publications with STRADA and Necrosis
Fibrosis Antibodies	>35 publications with STRADA and Fibrosis
Liver Neoplasms Antibodies	>34 publications with STRADA and Liver Neoplasms
Hypertension Antibodies	>32 publications with STRADA and Hypertension

Organs/Tissues associated with STRADA recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>371 publications with STRADA and Blood
Brain Antibodies	>225 publications with STRADA and Brain
Liver Antibodies	>149 publications with STRADA and Liver
Vascular Antibodies	>145 publications with STRADA and Vascular
Kidney Antibodies	>125 publications with STRADA and Kidney
Muscle Antibodies	>121 publications with STRADA and Muscle
Bone Antibodies	>114 publications with STRADA and Bone
Heart Antibodies	>90 publications with STRADA and Heart
Lung Antibodies	>76 publications with STRADA and Lung
Skin Antibodies	>68 publications with STRADA and Skin