CFP Recombinant Protein

Name: CFP Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205664
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205664

CFP is a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CFP, Recombinant Protein

Full Product Name

CFP, 28-469aa, Human, His tag, E Coli (Denatured)

Product Gene Name

CFP recombinant protein

Product Synonym Names

Complement factor properdin; BFD; PFC; PFD; PROPERDIN

Sequence

MGSSHHHHHH SSGLVPRGSH MGSDPVLCFT QYEESSGKCK GLLGGGVSVE DCCLNTAFAY QKRSGGLCQP CRSPRWSLWS TWAPCSVTCS EGSQLRYRRC VGWNGQCSGK VAPGTLEWQL QACEDQQCCP EMGGWSGWGP WEPCSVTCSK GTRTRRRACN HPAPKCGGHC PGQAQESEAC DTQQVCPTHG AWATWGPWTP CSASCHGGPH EPKETRSRKC SAPEPSQKPP GKPCPGLAYE QRRCTGLPPC PVAGGWGPWG PVSPCPVTCG LGQTMEQRTC NHPVPQHGGP FCAGDATRTH ICNTAVPCPV DGEWDSWGEW SPCIRRNMKS ISCQEIPGQQ SRGRTCRGRK FDGHRCAGQQ QDIRHCYSIQ HCPLKGSWSE WSTWGLCMPP CGPNPTRARQ RLCTPLLPKY PPTVSMVEGQ GEKNVTFWGR PLPRCEELQG QKLVVEEKRP CLHVPACKDP EEEEL

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Purity/Purification

> 80% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

50.9 kDa (465aa)

OMIM

X57748 mRNA

3D Structure

ModBase 3D Structure for P27918

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for CFP recombinant protein

Immunology

Applications Tested/Suitable for CFP recombinant protein

SDS-PAGE

Application Notes for CFP recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for CFP recombinant protein

Hartmann S., et al. (2000) J. Biol. Chem. 275:28569-28574; Liu T., et al. (2005) J. Proteome Res. 4:2070-2080;

Other Notes

Small volumes of CFP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CFP purchase

MBS205664 is a recombinant protein targeting CFP. Also known as CFP, 28-469aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CFP. It may not necessarily be applicable to this product.

NCBI GI #

4505737

NCBI GeneID

5199

NCBI Accession #

NP_002612

UniProt Primary Accession #

P27918

UniProt Secondary Accession #

O15134; O15135; O15136; O75826

UniProt Related Accession #

P27918

GenBank Nucleotide #

NM_002621.2

NCBI Official Full Name

properdin

NCBI Official Synonym Full Names

complement factor properdin

NCBI Official Symbol

CFP

NCBI Official Synonym Symbols

BFD; PFC; PFD; PROPERDIN

UniProt Protein Name

Properdin

UniProt Synonym Protein Names

Complement factor P

Protein Family

Properdin

UniProt Gene Name

CFP

UniProt Synonym Gene Names

PFC

NCBI Protein Information

properdin

NCBI Summary for CFP

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]

UniProt Comments for CFP

A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.

Research Articles on CFP

1. data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CFP recombinant protein

Reference Product	PubMed Publications
ADAMTS13 recombinant protein	>1 publications with CFP and ADAMTS13

Pathways associated with CFP recombinant protein

Products by Pathway	Pathway Diagram
Complement Activation Pathway antibodies	Complement Activation Pathway Diagram
Defective B3GALTL Causes Peters-plus Syndrome (PpS) Pathway antibodies	Defective B3GALTL Causes Peters-plus Syndrome (PpS) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Associated With O-glycosylation Of Proteins Pathway antibodies	Diseases Associated With O-glycosylation Of Proteins Pathway Diagram
Diseases Of Glycosylation Pathway antibodies	Diseases Of Glycosylation Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram

Diseases associated with CFP recombinant protein

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>366 publications with CFP and Lung Diseases
Diabetes Mellitus Antibodies	>193 publications with CFP and Diabetes Mellitus
Poisoning Antibodies	>141 publications with CFP and Poisoning
Necrosis Antibodies	>101 publications with CFP and Necrosis
Inflammation Antibodies	>87 publications with CFP and Inflammation
Disease Models, Animal Antibodies	>69 publications with CFP and Disease Models, Animal
Weight Loss Antibodies	>60 publications with CFP and Weight Loss
Hepatitis Antibodies	>59 publications with CFP and Hepatitis
Fibrosis Antibodies	>51 publications with CFP and Fibrosis
Kidney Diseases Antibodies	>46 publications with CFP and Kidney Diseases

Organs/Tissues associated with CFP recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>970 publications with CFP and Blood
Brain Antibodies	>199 publications with CFP and Brain
Lung Antibodies	>186 publications with CFP and Lung
Bone Antibodies	>169 publications with CFP and Bone
Muscle Antibodies	>147 publications with CFP and Muscle
Vascular Antibodies	>113 publications with CFP and Vascular
Liver Antibodies	>79 publications with CFP and Liver
Spleen Antibodies	>35 publications with CFP and Spleen
Connective Tissue Antibodies	>30 publications with CFP and Connective Tissue
Bone Marrow Antibodies	>30 publications with CFP and Bone Marrow