BCAR1 Recombinant Protein

Name: BCAR1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205668
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205668

BCAR1, or CAS, is an Src family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion. Recombinant human BCAR1 protein, fused to His-tag at N-terminus, was expressed in E Coli. More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BCAR1, Recombinant Protein

Full Product Name

BCAR1, 465-848aa, Human, His tag, E Coli (Denatured)

Product Gene Name

BCAR1 recombinant protein

Product Synonym Names

breast cancer anti-estrogen resistance 1; CAS; CAS1; CASS1; CRKAS; P130Cas

Sequence

MGSSHHHHHH SSGLVPRGSH MGSRLQQGVS ATVAHLLDLA GSAGATGSWR SPSEPQEPLV QDLQAAVAAV QSAVHELLEF ARSAVGNAAH TSDRALHAKL SRQLQKMEDV HQTLVAHGQA LDAGRGGSGA TLEDLDRLVA CSRAVPEDAK QLASFLHGNA SLLFRRTKAT APGPEGGGTL HPNPTDKTSS IQSRPLPSPP KFTSQDSPDG QYENSEGGWM EDYDYVHLQG KEEFEKTQKE LLEKGSITRQ GKSQLELQQL KQFERLEQEV SRPIDHDLAN WTPAQPLAPG RTGGLGPSDR QLLLFYLEQC EANLTTLTNA VDAFFTAVAT NQPPKIFVAH SKFVILSAHK LVFIGDTLSR QAKAADVRSQ VTHYSNLLCD LLRGIVATTK AAALQYPSPS AAQDMVE

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

43.9kDa (407aa)

OMIM

AJ242987 mRNA

3D Structure

ModBase 3D Structure for P56945

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for BCAR1 recombinant protein

Cancer

Applications Tested/Suitable for BCAR1 recombinant protein

SDS-PAGE

Application Notes for BCAR1 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for BCAR1 recombinant protein

Konstantinovsky,S, et al. (2012) Clin. Exp. Metastasis 29 (6), 527-540; Huang,W., et al. (2012) PLoS ONE 7 (4), E36124;

Other Notes

Small volumes of BCAR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCAR1 purchase

MBS205668 is a recombinant protein targeting BCAR1. Also known as BCAR1, 465-848aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BCAR1. It may not necessarily be applicable to this product.

NCBI GI #

44662836

NCBI GeneID

9564

NCBI Accession #

NP_055382

UniProt Primary Accession #

P56945

UniProt Secondary Accession #

B3KWD7; B4DEV4; B4DGB5; B4DIW5; B7Z7X7; E9PCL5; E9PCV2; F5GXA2; F5GXV6; F5H7Z0; F8WA69

UniProt Related Accession #

P56945

GenBank Nucleotide #

NM_014567.4

NCBI Official Full Name

breast cancer anti-estrogen resistance protein 1 isoform 6

NCBI Official Synonym Full Names

BCAR1, Cas family scaffolding protein

NCBI Official Symbol

BCAR1

NCBI Official Synonym Symbols

CAS; CAS1; CASS1; CRKAS; P130Cas

UniProt Protein Name

Breast cancer anti-estrogen resistance protein 1

UniProt Synonym Protein Names

CRK-associated substrate; Cas scaffolding protein family member 1; p130cas

Protein Family

Breast cancer anti-estrogen resistance protein

UniProt Gene Name

BCAR1

UniProt Synonym Gene Names

CAS; CASS1; CRKAS

NCBI Protein Information

breast cancer anti-estrogen resistance protein 1

NCBI Summary for BCAR1

The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]

UniProt Comments for BCAR1

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Research Articles on BCAR1

1. the p130Cas FAT domain uniquely confers a mechanosensing function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BCAR1 recombinant protein

Reference Product	PubMed Publications
CRK recombinant protein	>426 publications with BCAR1 and CRK
SRC recombinant protein	>177 publications with BCAR1 and SRC
PTK2 recombinant protein	>109 publications with BCAR1 and PTK2
PXN recombinant protein	>70 publications with BCAR1 and PXN
FYN recombinant protein	>14 publications with BCAR1 and FYN
PTK2B recombinant protein	>12 publications with BCAR1 and PTK2B
CRKL recombinant protein	>10 publications with BCAR1 and CRKL
DOCK1 recombinant protein	>6 publications with BCAR1 and DOCK1
PTPN1 recombinant protein	>4 publications with BCAR1 and PTPN1

Pathways associated with BCAR1 recombinant protein

Products by Pathway	Pathway Diagram
Bacterial Invasion Of Epithelial Cells Pathway antibodies	Bacterial Invasion Of Epithelial Cells Pathway Diagram
Bacterial Invasion Of Epithelial Cells Pathway antibodies	Bacterial Invasion Of Epithelial Cells Pathway Diagram
CDC42 Signaling Events Pathway antibodies	CDC42 Signaling Events Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
EGF/EGFR Signaling Pathway antibodies	EGF/EGFR Signaling Pathway Diagram
EPHA2 Forward Signaling Pathway antibodies	EPHA2 Forward Signaling Pathway Diagram
Endothelins Pathway antibodies	Endothelins Pathway Diagram

Diseases associated with BCAR1 recombinant protein

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>54 publications with BCAR1 and Breast Neoplasms
Cell Transformation, Neoplastic Antibodies	>36 publications with BCAR1 and Cell Transformation, Neoplastic
Neoplasm Invasiveness Antibodies	>30 publications with BCAR1 and Neoplasm Invasiveness
Neoplasm Metastasis Antibodies	>22 publications with BCAR1 and Neoplasm Metastasis
Lung Neoplasms Antibodies	>18 publications with BCAR1 and Lung Neoplasms
Neoplasms, Experimental Antibodies	>16 publications with BCAR1 and Neoplasms, Experimental
Adenocarcinoma Antibodies	>13 publications with BCAR1 and Adenocarcinoma
Inflammation Antibodies	>10 publications with BCAR1 and Inflammation
Cardiovascular Diseases Antibodies	>8 publications with BCAR1 and Cardiovascular Diseases
Kidney Diseases Antibodies	>6 publications with BCAR1 and Kidney Diseases

Organs/Tissues associated with BCAR1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>42 publications with BCAR1 and Vascular
Muscle Antibodies	>25 publications with BCAR1 and Muscle
Lung Antibodies	>24 publications with BCAR1 and Lung
Bone Antibodies	>19 publications with BCAR1 and Bone
Heart Antibodies	>17 publications with BCAR1 and Heart
Prostate Antibodies	>16 publications with BCAR1 and Prostate
Kidney Antibodies	>15 publications with BCAR1 and Kidney
Brain Antibodies	>13 publications with BCAR1 and Brain
Pancreas Antibodies	>11 publications with BCAR1 and Pancreas
Liver Antibodies	>8 publications with BCAR1 and Liver