GDI1 Recombinant Protein

Name: GDI1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205692
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205692

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GDI1, Recombinant Protein

Full Product Name

GDI1, 1-447aa, Human, His tag, E Coli

Product Gene Name

GDI1 recombinant protein

Product Synonym Names

Rab GDP dissociation inhibitor alpha; Rab GDP dissociation inhibitor alpha; GDP dissociation inhibitor 1; 1A; GDIL; MRX41; MRX48; OPHN2; RABGD1A; RABGDIA; XAP-4

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMDEEYDV IVLGTGLTEC ILSGIMSVNG KKVLHMDRNP YYGGESSSIT PLEELYKRFQ LLEGPPESMG RGRDWNVDLI PKFLMANGQL VKMLLYTEVT RYLDFKVVEG SFVYKGGKIY KVPSTETEAL ASNLMGMFEK RRFRKFLVFV ANFDENDPKT FEGVDPQTTS MRDVYRKFDL GQDVIDFTGH ALALYRTDDY LDQPCLETVN RIKLYSESLA RYGKSPYLYP LYGLGELPQG FARLSAIYGG TYMLNKPVDD IIMENGKVVG VKSEGEVARC KQLICDPSYI PDRVRKAGQV IRIICILSHP IKNTNDANSC QIIIPQNQVN RKSDIYVCMI SYAHNVAAQG KYIAIASTTV ETTDPEKEVE PALELLEPID QKFVAISDLY EPIDDGCESQ VFCSCSYDAT THFETTCNDI KDIYKRMAGT AFDFENMKRK QNDVFGEAEQ

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

53.0kDa (470aa)

OMIM

X79353 mRNA

3D Structure

ModBase 3D Structure for P31150

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for GDI1 recombinant protein

Signal Transduction

Applications Tested/Suitable for GDI1 recombinant protein

SDS-PAGE

Product References and Citations for GDI1 recombinant protein

Bachner D, Sedlacek Z., et al. (1995) Hum Mol Genet 4 (4): 701-8.; Sedlacek Z, Konecki DS., et al. (1995) Mamm Genome 5 (10): 633-9.;

Other Notes

Small volumes of GDI1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDI1 purchase

MBS205692 is a recombinant protein targeting GDI1. Also known as GDI1, 1-447aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GDI1. It may not necessarily be applicable to this product.

NCBI GI #

4503971

NCBI GeneID

2664

NCBI Accession #

NP_001484

UniProt Primary Accession #

P31150

UniProt Secondary Accession #

P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6

UniProt Related Accession #

P31150

GenBank Nucleotide #

NM_001493.2

NCBI Official Full Name

rab GDP dissociation inhibitor alpha

NCBI Official Synonym Full Names

GDP dissociation inhibitor 1

NCBI Official Symbol

GDI1

NCBI Official Synonym Symbols

1A; GDIL; MRX41; MRX48; OPHN2; XAP-4; RABGD1A; RABGDIA

UniProt Protein Name

Rab GDP dissociation inhibitor alpha

UniProt Synonym Protein Names

Guanosine diphosphate dissociation inhibitor 1; GDI-1; Oligophrenin-2; Protein XAP-4

Protein Family

Guanosine nucleotide diphosphate dissociation inhibitor

UniProt Gene Name

GDI1

UniProt Synonym Gene Names

GDIL; OPHN2; RABGDIA; XAP4; Rab GDI alpha; GDI-1

NCBI Protein Information

rab GDP dissociation inhibitor alpha

NCBI Summary for GDI1

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008]

UniProt Comments for GDI1

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.

Research Articles on GDI1

1. Data confirm isolated adrenocorticotropin deficiency (IAD) as autoimmune disease; RABGDIA (human, human recombinant, or rat) exhibits characteristics of autoantigen in anterior pituitary; patients with IAD exhibit autoantibodies against RABGDIA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDI1 recombinant protein

Reference Product	PubMed Publications
RHOA recombinant protein	>2 publications with GDI1 and RHOA
RAC1 recombinant protein	>1 publications with GDI1 and RAC1

Pathways associated with GDI1 recombinant protein

Products by Pathway	Pathway Diagram
Integrated Breast Cancer Pathway antibodies	Integrated Breast Cancer Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
RAB GEFs Exchange GTP For GDP On RABs Pathway antibodies	RAB GEFs Exchange GTP For GDP On RABs Pathway Diagram
Rho GTPase Cycle Pathway antibodies	Rho GTPase Cycle Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By Rho GTPases Pathway antibodies	Signaling By Rho GTPases Pathway Diagram
Signaling Mediated By P38-alpha And P38-beta Pathway antibodies	Signaling Mediated By P38-alpha And P38-beta Pathway Diagram
Vesicle-mediated Transport Pathway antibodies	Vesicle-mediated Transport Pathway Diagram

Diseases associated with GDI1 recombinant protein

Disease Name	Pubmed Publications
Mental Retardation, X-Linked Antibodies	>19 publications with GDI1 and Mental Retardation, X-Linked
Cognition Disorders Antibodies	>4 publications with GDI1 and Cognition Disorders
Memory Disorders Antibodies	>4 publications with GDI1 and Memory Disorders
Learning Disorders Antibodies	>2 publications with GDI1 and Learning Disorders
Prenatal Injuries Antibodies	>1 publications with GDI1 and Prenatal Injuries
Fetal Growth Retardation Antibodies	>1 publications with GDI1 and Fetal Growth Retardation
Abnormalities, Drug-Induced Antibodies	>1 publications with GDI1 and Abnormalities, Drug-Induced
Inflammation Antibodies	>1 publications with GDI1 and Inflammation
Prenatal Exposure Delayed Effects Antibodies	>1 publications with GDI1 and Prenatal Exposure Delayed Effects
MENTAL RETARDATION, X-LINKED 41 Antibodies	>1 publications with GDI1 and MENTAL RETARDATION, X-LINKED 41

Organs/Tissues associated with GDI1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>23 publications with GDI1 and Brain
Eye Antibodies	>2 publications with GDI1 and Eye
Testis Antibodies	>1 publications with GDI1 and Testis
Embryonic Tissue Antibodies	>1 publications with GDI1 and Embryonic Tissue
Uterus Antibodies	>1 publications with GDI1 and Uterus
Kidney Antibodies	>1 publications with GDI1 and Kidney
Lung Antibodies	>1 publications with GDI1 and Lung
Muscle Antibodies	>1 publications with GDI1 and Muscle