RLBP1 Recombinant Protein

Name: RLBP1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205705
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205705

RLBP1 is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RLBP1, Recombinant Protein

Full Product Name

RLBP1, 1-317aa, Human, His tag, E Coli (Denatured)

Product Gene Name

RLBP1 recombinant protein

Product Synonym Names

retinaldehyde-binding protein 1; CRALBP

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSEGVGT FRMVPEEEQE LRAQLEQLTT KDHGPVFGPC SQLPRHTLQK AKDELNEREE TREEAVRELQ EMVQAQAASG EELAVAVAER VQEKDSGFFL RFIRARKFNV GRAYELLRGY VNFRLQYPEL FDSLSPEAVR CTIEAGYPGV LSSRDKYGRV VMLFNIENWQ SQEITFDEIL QAYCFILEKL LENEETQING FCIIENFKGF TMQQAASLRT SDLRKMVDML QDSFPARFKA IHFIHQPWYF TTTYNVVKPF LKSKLLERVF VHGDDLSGFY QEIDENILPS DFGGTLPKYD GKAVAEQLFG PQAQAENTAF

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1.0 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

38.9kDa (340aa)

OMIM

J04213 mRNA

3D Structure

ModBase 3D Structure for P12271

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for RLBP1 recombinant protein

Neuroscience

Applications Tested/Suitable for RLBP1 recombinant protein

SDS-PAGE

Application Notes for RLBP1 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for RLBP1 recombinant protein

Nojima,K., et al. (2012) Ophthalmic Genet. 33 (2), 83-88; Neutzner,R.V., et al. (2011) Ophthalmologe 108 (11), 1045-1049;

Other Notes

Small volumes of RLBP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RLBP1 purchase

MBS205705 is a recombinant protein targeting RLBP1. Also known as RLBP1, 1-317aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for RLBP1. It may not necessarily be applicable to this product.

NCBI GI #

4506541

NCBI GeneID

6017

NCBI Accession #

NP_000317

UniProt Primary Accession #

P12271

UniProt Secondary Accession #

B2R667

UniProt Related Accession #

P12271

GenBank Nucleotide #

NM_000326.4

NCBI Official Full Name

retinaldehyde-binding protein 1

NCBI Official Synonym Full Names

retinaldehyde binding protein 1

NCBI Official Symbol

RLBP1

NCBI Official Synonym Symbols

CRALBP

UniProt Protein Name

Retinaldehyde-binding protein 1

UniProt Synonym Protein Names

Cellular retinaldehyde-binding protein

Protein Family

Retinaldehyde-binding protein

UniProt Gene Name

RLBP1

UniProt Synonym Gene Names

CRALBP

NCBI Protein Information

retinaldehyde-binding protein 1

NCBI Summary for RLBP1

The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008]

UniProt Comments for RLBP1

Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.

Research Articles on RLBP1

1. we provide evidence for an allosteric modulation of the enzymatic activity by 11-cis retinoids. This regulation is independent from cellular retinaldehyde-binding protein (CRALBP), the major cis-retinoid binding protein.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RLBP1 recombinant protein

Reference Product	PubMed Publications
RDH5 recombinant protein	>9 publications with RLBP1 and RDH5
RPE65 recombinant protein	>8 publications with RLBP1 and RPE65
RHO recombinant protein	>3 publications with RLBP1 and RHO
OPN1SW recombinant protein	>1 publications with RLBP1 and OPN1SW
RBP3 recombinant protein	>1 publications with RLBP1 and RBP3

Pathways associated with RLBP1 recombinant protein

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Associated With Visual Transduction Pathway antibodies	Diseases Associated With Visual Transduction Pathway Diagram
Diseases Of Signal Transduction Pathway antibodies	Diseases Of Signal Transduction Pathway Diagram
Retinoid Cycle Disease Events Pathway antibodies	Retinoid Cycle Disease Events Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies	The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
The Retinoid Cycle In Cones (daylight Vision) Pathway antibodies	The Retinoid Cycle In Cones (daylight Vision) Pathway Diagram
Visual Phototransduction Pathway antibodies	Visual Phototransduction Pathway Diagram
Vitamin A And Carotenoid Metabolism Pathway antibodies	Vitamin A And Carotenoid Metabolism Pathway Diagram
The Visual Cycle I (vertebrates) Pathway antibodies	The Visual Cycle I (vertebrates) Pathway Diagram

Diseases associated with RLBP1 recombinant protein

Disease Name	Pubmed Publications
Eye Diseases, Hereditary Antibodies	>21 publications with RLBP1 and Eye Diseases, Hereditary
Fundus Albipunctatus Antibodies	>8 publications with RLBP1 and Fundus Albipunctatus
Newfoundland Rod-Cone Dystrophy Antibodies	>2 publications with RLBP1 and Newfoundland Rod-Cone Dystrophy
Cardiovascular Diseases Antibodies	>1 publications with RLBP1 and Cardiovascular Diseases
Eye Abnormalities Antibodies	>1 publications with RLBP1 and Eye Abnormalities
Inflammation Antibodies	>1 publications with RLBP1 and Inflammation
Bothnia Retinal Dystrophy Antibodies	>1 publications with RLBP1 and Bothnia Retinal Dystrophy

Organs/Tissues associated with RLBP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>37 publications with RLBP1 and Eye
Brain Antibodies	>4 publications with RLBP1 and Brain
Muscle Antibodies	>1 publications with RLBP1 and Muscle