EDAR Recombinant Protein

Name: EDAR Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205783
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205783

EDAR is a member of the tumor necrosis factor receptor family. This protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development… More details

$245 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EDAR, Recombinant Protein

Full Product Name

EDAR, 27-448aa, Human, His tag, E Coli (Denatured)

Product Gene Name

EDAR recombinant protein

Product Synonym Names

Tumor necrosis factor receptor superfamily member EDAR; DL; ECTD10A; ECTD10B; ED1R; ED3; ED5; EDA-A1R; EDA1R; EDA3; HRM1

Sequence

MGSSHHHHHH SSGLVPRGSH MGSEYSNCGE NEYYNQTTGL CQECPPCGPG EEPYLSCGYG TKDEDYGCVP CPAEKFSKGG YQICRRHKDC EGFFRATVLT PGDMENDAEC GPCLPGYYML ENRPRNIYGM VCYSCLLAPP NTKECVGATS GASANFPGTS GSSTLSPFQH AHKELSGQGH LATALIIAMS TIFIMAIAIV LIIMFYILKT KPSAPACCTS HPGKSVEAQV SKDEEKKEAP DNVVMFSEKD EFEKLTATPA KPTKSENDAS SENEQLLSRS VDSDEEPAPD KQGSPELCLL SLVHLAREKS ATSNKSAGIQ SRRKKILDVY ANVCGVVEGL SPTELPFDCL EKTSRMLSST YNSEKAVVKT WRHLAESFGL KRDEIGGMTD GMQLFDRIST AGYSIPELLT KLVQIERLDA VESLCADILE WAGVVPPASQ PHAAS

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl (pH 8.0) containing 10% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

48.2 kDa (445aa)

OMIM

AF130988 mRNA

3D Structure

ModBase 3D Structure for Q9UNE0

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for EDAR recombinant protein

Signal Transduction

Applications Tested/Suitable for EDAR recombinant protein

SDS-PAGE

Application Notes for EDAR recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for EDAR recombinant protein

Yan M., et al. (2000) Science 290:523-527

Other Notes

Small volumes of EDAR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EDAR purchase

MBS205783 is a recombinant protein targeting EDAR. Also known as EDAR, 27-448aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for EDAR. It may not necessarily be applicable to this product.

NCBI GI #

11641231

NCBI GeneID

10913

NCBI Accession #

NP_071731

UniProt Primary Accession #

Q9UNE0

UniProt Secondary Accession #

Q52LL5; Q9UND9; B2R9H2; B4DLC5; D3DX74; E9PC98

UniProt Related Accession #

Q9UNE0

GenBank Nucleotide #

NM_022336.3

NCBI Official Full Name

tumor necrosis factor receptor superfamily member EDAR

NCBI Official Synonym Full Names

ectodysplasin A receptor

NCBI Official Symbol

EDAR

NCBI Official Synonym Symbols

DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R

UniProt Protein Name

Tumor necrosis factor receptor superfamily member EDAR

UniProt Synonym Protein Names

Anhidrotic ectodysplasin receptor 1; Downless homolog; EDA-A1 receptor; Ectodermal dysplasia receptor; Ectodysplasin-A receptor

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

EDAR

UniProt Synonym Gene Names

NCBI Protein Information

tumor necrosis factor receptor superfamily member EDAR

NCBI Summary for EDAR

This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]

UniProt Comments for EDAR

Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.

Research Articles on EDAR

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with EDAR recombinant protein

Reference Product	PubMed Publications
EDA recombinant protein	>155 publications with EDAR and EDA
EDARADD recombinant protein	>75 publications with EDAR and EDARADD
WNT10B recombinant protein	>7 publications with EDAR and WNT10B
SLC45A2 recombinant protein	>4 publications with EDAR and SLC45A2
SLC24A5 recombinant protein	>4 publications with EDAR and SLC24A5
CTGF recombinant protein	>1 publications with EDAR and CTGF
TRAF3 recombinant protein	>1 publications with EDAR and TRAF3
CYLD recombinant protein	>1 publications with EDAR and CYLD

Pathways associated with EDAR recombinant protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Integrated Breast Cancer Pathway antibodies	Integrated Breast Cancer Pathway Diagram
TNFR2 Non-canonical NF-kB Pathway antibodies	TNFR2 Non-canonical NF-kB Pathway Diagram
TNFs Bind Their Physiological Receptors Pathway antibodies	TNFs Bind Their Physiological Receptors Pathway Diagram

Diseases associated with EDAR recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>73 publications with EDAR and Necrosis
Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive Antibodies	>35 publications with EDAR and Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Inflammation Antibodies	>8 publications with EDAR and Inflammation
Nervous System Diseases Antibodies	>7 publications with EDAR and Nervous System Diseases
Disease Models, Animal Antibodies	>7 publications with EDAR and Disease Models, Animal
Chromosome Aberrations Antibodies	>2 publications with EDAR and Chromosome Aberrations
Breast Neoplasms Antibodies	>2 publications with EDAR and Breast Neoplasms
Ectodermal Dysplasia 3, Anhidrotic Antibodies	>2 publications with EDAR and Ectodermal Dysplasia 3, Anhidrotic
Neurobehavioral Manifestations Antibodies	>1 publications with EDAR and Neurobehavioral Manifestations
Hyperplasia Antibodies	>1 publications with EDAR and Hyperplasia

Organs/Tissues associated with EDAR recombinant protein

Organ/Tissue Name	Pubmed Publications
Mouth Antibodies	>44 publications with EDAR and Mouth
Embryonic Tissue Antibodies	>39 publications with EDAR and Embryonic Tissue
Brain Antibodies	>7 publications with EDAR and Brain
Heart Antibodies	>5 publications with EDAR and Heart
Kidney Antibodies	>2 publications with EDAR and Kidney
Uncharacterized Tissue Antibodies	>1 publications with EDAR and Uncharacterized Tissue
Thymus Antibodies	>1 publications with EDAR and Thymus
Prostate Antibodies	>1 publications with EDAR and Prostate