NCS1 Recombinant Protein

Name: NCS1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205866
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205866

NCS1 is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. This protein regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NCS1, Recombinant Protein

Full Product Name

NCS1, 1-190aa, Human, His tag, E Coli

Product Gene Name

NCS1 recombinant protein

Product Synonym Names

Neuronal calcium sensor 1 isoform 1; FLuP; FREQ

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMGKSNSK LKPEVVEELT RKTYFTEKEV QQWYKGFIKD CPSGQLDAAG FQKIYKQFFP FGDPTKFATF VFNVFDENKD GRIEFSEFIQ ALSVTSRGTL DEKLRWAFKL YDLDNDGYIT RNEMLDIVDA IYQMVGNTVE LPEEENTPEK RVDRIFAMMD KNADGKLTLQ EFQEGSKADP SIVQALSLYD GLV

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

24.3. kDa (213aa) confirmed by MALDI-TOF

OMIM

X84048 mRNA

3D Structure

ModBase 3D Structure for P62166

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for NCS1 recombinant protein

Neuroscience

Applications Tested/Suitable for NCS1 recombinant protein

SDS-PAGE

Product References and Citations for NCS1 recombinant protein

Nakamura T.Y., et al (2001). Proc. Natl. Acad. Sci. u.S.A. 98:12808-12813; Bahi N., et al (2003). Hum. Mol. Genet. 12:1415-1425

Other Notes

Small volumes of NCS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCS1 purchase

MBS205866 is a recombinant protein targeting NCS1. Also known as NCS1, 1-190aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NCS1. It may not necessarily be applicable to this product.

NCBI GI #

17738308

NCBI GeneID

23413

NCBI Accession #

NP_055101

UniProt Primary Accession #

P62166

UniProt Secondary Accession #

P36610; Q9UK26; E9PAY3

UniProt Related Accession #

P62166

GenBank Nucleotide #

NM_014286.3

NCBI Official Full Name

neuronal calcium sensor 1 isoform 1

NCBI Official Synonym Full Names

neuronal calcium sensor 1

NCBI Official Symbol

NCS1

NCBI Official Synonym Symbols

FLUP; FREQ

UniProt Protein Name

Neuronal calcium sensor 1

UniProt Synonym Protein Names

Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein

Protein Family

Purine-uracil permease

UniProt Gene Name

NCS1

UniProt Synonym Gene Names

FLUP; FREQ; NCS-1

NCBI Protein Information

neuronal calcium sensor 1

NCBI Summary for NCS1

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for NCS1

Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (). Stimulates PI4KB kinase activity (). Involved in long-term synaptic plasticity through its interaction with PICK1 (). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel ().

Research Articles on NCS1

1. Results show that although NCS-1 Var2mRNA can be detected, protein expression was not detectable. When overexpressed in cell lines NCS-1 Var2 appears to be folded properly, yet it has a lower calcium affinity. Because most NCS-1 binding to its protein partners requires calcium binding, it is unlikely that NCS-1 Var2 would play a major regulatory role in cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with NCS1 recombinant protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>2 publications with NCS1 and Heart Diseases
Neoplasm Invasiveness Antibodies	>1 publications with NCS1 and Neoplasm Invasiveness
Cardiomegaly Antibodies	>1 publications with NCS1 and Cardiomegaly
Glucose Intolerance Antibodies	>1 publications with NCS1 and Glucose Intolerance
Learning Disorders Antibodies	>1 publications with NCS1 and Learning Disorders
Memory Disorders Antibodies	>1 publications with NCS1 and Memory Disorders
Hypertrophy Antibodies	>1 publications with NCS1 and Hypertrophy
Necrosis Antibodies	>1 publications with NCS1 and Necrosis

Organs/Tissues associated with NCS1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with NCS1 and Brain
Nerve Antibodies	>4 publications with NCS1 and Nerve
Heart Antibodies	>3 publications with NCS1 and Heart
Eye Antibodies	>2 publications with NCS1 and Eye
Blood Antibodies	>1 publications with NCS1 and Blood
Skin Antibodies	>1 publications with NCS1 and Skin
Kidney Antibodies	>1 publications with NCS1 and Kidney