LOX Recombinant Protein

Name: LOX Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205887
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205887

LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LOX, Recombinant Protein

Full Product Name

LOX, 169-417aa, Human, His tag, E Coli (Denatured)

Product Gene Name

LOX recombinant protein

Product Synonym Names

Protein-lysine 6-oxidase; Lysyl oxidase

Sequence

MGSSHHHHHH SSGLVPRGSH MGSDDPYNPY KYSDDNPYYN YYDTYERPRP GGRYRPGYGT GYFQYGLPDL VADPYYIQAS TYVQKMSMYN LRCAAEENCL ASTAYRADVR DYDHRVLLRF PQRVKNQGTS DFLPSRPRYS WEWHSCHQHY HSMDEFSHYD LLDANTQRRV AEGHKASFCL EDTSCDYGYH RRFACTAHTQ GLSPGCYDTY GADIDCQWID ITDVKPGNYI LKVSVNPSYL VPESDYTNNV VRCDIRYTGH HAYASGCTIS PY

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

31.4 kDa (272aa)

OMIM

S78694 mRNA

3D Structure

ModBase 3D Structure for P28300

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for LOX recombinant protein

Cytoskeleton

Applications Tested/Suitable for LOX recombinant protein

SDS-PAGE

Application Notes for LOX recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for LOX recombinant protein

Kim Y., et al. (1995) J. Biol. Chem. 270:7176-7182.; Contente S., et al. (1999) Mol. Cell. Biochem. 194:79-91.

Other Notes

Small volumes of LOX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LOX purchase

MBS205887 is a recombinant protein targeting LOX. Also known as LOX, 169-417aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LOX. It may not necessarily be applicable to this product.

NCBI GI #

20149540

NCBI GeneID

4015

NCBI Accession #

NP_002308

UniProt Primary Accession #

P28300

UniProt Secondary Accession #

Q5FWF0; B2R5Q3

UniProt Related Accession #

P28300

GenBank Nucleotide #

NM_002317.6

NCBI Official Full Name

protein-lysine 6-oxidase isoform 1 preproprotein

NCBI Official Synonym Full Names

lysyl oxidase

NCBI Official Symbol

LOX

NCBI Official Synonym Symbols

AAT10

UniProt Protein Name

Protein-lysine 6-oxidase

UniProt Synonym Protein Names

Lysyl oxidase

Protein Family

Linoleate 9/13-lipoxygenase

UniProt Gene Name

LOX

NCBI Protein Information

protein-lysine 6-oxidase

NCBI Summary for LOX

This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]

UniProt Comments for LOX

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture ().

Research Articles on LOX

1. LOX expression was mildly but significantly upregulated in CD34+-derived primary myelofibrosis megakaryocytes and platelets compared with controls. These megakaryocytes showed a greater tendency to adhere and spread to monomeric collagen, and this was inhibited by the LOX-specific inhibitor BAPN.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LOX recombinant protein

Reference Product	PubMed Publications
LOXL2 recombinant protein	>77 publications with LOX and LOXL2
LOXL1 recombinant protein	>71 publications with LOX and LOXL1
BMP1 recombinant protein	>9 publications with LOX and BMP1
FBLN5 recombinant protein	>8 publications with LOX and FBLN5
ELN recombinant protein	>5 publications with LOX and ELN
PCOLCE recombinant protein	>4 publications with LOX and PCOLCE

Pathways associated with LOX recombinant protein

Products by Pathway	Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Canonical And Non-Canonical TGF-B Signaling Pathway antibodies	Canonical And Non-Canonical TGF-B Signaling Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Crosslinking Of Collagen Fibrils Pathway antibodies	Crosslinking Of Collagen Fibrils Pathway Diagram
Elastic Fibre Formation Pathway antibodies	Elastic Fibre Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with LOX recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>837 publications with LOX and Inflammation
Cardiovascular Diseases Antibodies	>751 publications with LOX and Cardiovascular Diseases
Disease Models, Animal Antibodies	>518 publications with LOX and Disease Models, Animal
Necrosis Antibodies	>299 publications with LOX and Necrosis
Heart Diseases Antibodies	>233 publications with LOX and Heart Diseases
Fibrosis Antibodies	>200 publications with LOX and Fibrosis
Neoplasms, Experimental Antibodies	>177 publications with LOX and Neoplasms, Experimental
Hypertension Antibodies	>176 publications with LOX and Hypertension
Lung Neoplasms Antibodies	>145 publications with LOX and Lung Neoplasms
Edema Antibodies	>145 publications with LOX and Edema

Organs/Tissues associated with LOX recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>891 publications with LOX and Vascular
Muscle Antibodies	>484 publications with LOX and Muscle
Brain Antibodies	>477 publications with LOX and Brain
Lung Antibodies	>371 publications with LOX and Lung
Heart Antibodies	>347 publications with LOX and Heart
Liver Antibodies	>317 publications with LOX and Liver
Bone Antibodies	>287 publications with LOX and Bone
Skin Antibodies	>214 publications with LOX and Skin
Kidney Antibodies	>201 publications with LOX and Kidney
Embryonic Tissue Antibodies	>180 publications with LOX and Embryonic Tissue