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EEF2K Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205915

Eukaryotic elongation factor-2 kinase, also known as EEF2K, is threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EEF2K, Recombinant Protein
Full Product Name
EEF2K, 1-725aa, Human, His tag, E Coli
Product Gene Name
EEF2K recombinant protein
Product Synonym Names
Eukaryotic elongation factor-2 kinase; eEF-2K; HSu93850; eEF2K
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMADEDLI FRLEGVDGGQ SPRAGHDGDS DGDSDDEEGY FICPITDDPS SNQNVNSKVN KYYSNLTKSE RYSSSGSPAN SFHFKEAWKH AIQKAKHMPD PWAEFHLEDI ATERATRHRY NAVTGEWLDD EVLIKMASQP FGRGAMRECF RTKKLSNFLH AQQWKGASNY VAKRYIEPVD RDVYFEDVRL QMEAKLWGEE YNRHKPPKQV DIMQMCIIEL KDRPGKPLFH LEHYIEGKYI KYNSNSGFVR DDNIRLTPQA FSHFTFERSG HQLIVVDIQG VGDLYTDPQI HTETGTDFGD GNLGVRGMAL FFYSHACNRI CESMGLAPFD LSPRERDAVN QNTKLLQSAK TILRGTEEKC GSPRVRTLSG SRPPLLRPLS ENSGDENMSD VTFDSLPSSP SSATPHSQKL DHLHWPVFSD LDNMASRDHD HLDNHRESEN SGDSGYPSEK RGELDDPEPR EHGHSYSNRK YESDEDSLGS SGRVCVEKWN LLNSSRLHLP RASAVALEVQ RLNALDLEKK IGKSILGKVH LAMVRYHEGG RFCEKGEEWD QESAVFHLEH AANLGELEAI VGLGLMYSQL PHHILADVSL KETEENKTKG FDYLLKAAEA GDRQSMILVA RAFDSGQNLS PDRCQDWLEA LHWYNTALEM TDCDEGGEYD GMQDEPRYMM LAREAEMLFT GGYGLEKDPQ RSGDLYTQAA EAAMEAMKGR LANQYYQKAE EAWAQMEE
Host
E Coli
Form/Format
Liquid. In phosphate buffered saline (pH 7.4), 10% glycerol
Purity/Purification
> 85% by SDS-PAGE
Concentration
0.25 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
84.6 kDa (748aa)
OMIM
U93850 mRNA
3D Structure
ModBase 3D Structure for O00418
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for EEF2K recombinant protein

Epigenomics (Transcription & Translation)
Applications Tested/Suitable for EEF2K recombinant protein
SDS-PAGE

SDS-Page of EEF2K recombinant protein

EEF2K Recombinant Protein – Cat# MBS205915

Product References and Citations for EEF2K recombinant protein

Ryazanov A.G., et al. (1997) Proc. Natl. Acad. Sci. u.S.A. 94:4884-4889; Knebel A., et al. (2001) EMBO J. 20:4360-4369

Other Notes

Small volumes of EEF2K recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EEF2K purchase

MBS205915 is a recombinant protein targeting EEF2K. Also known as EEF2K, 1-725aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for EEF2K. It may not necessarily be applicable to this product.

NCBI GI #
9558749
NCBI GeneID
29904
NCBI Accession #
NP_037434
UniProt Primary Accession #
O00418
UniProt Secondary Accession #
Q8N588
UniProt Related Accession #
O00418
GenBank Nucleotide #
NM_013302.3
NCBI Official Full Name
eukaryotic elongation factor 2 kinase
NCBI Official Synonym Full Names
eukaryotic elongation factor 2 kinase
NCBI Official Symbol
EEF2K
NCBI Official Synonym Symbols
eEF-2K; HSU93850
UniProt Protein Name
Eukaryotic elongation factor 2 kinase
UniProt Synonym Protein Names
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
Protein Family
Eukaryotic elongation factor 2 kinase
UniProt Gene Name
EEF2K
UniProt Synonym Gene Names
eEF-2 kinase; eEF-2K
NCBI Protein Information
eukaryotic elongation factor 2 kinase

NCBI Summary for EEF2K

This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
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UniProt Comments for EEF2K

Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
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Research Articles on EEF2K

1. Data suggest forkhead box M1 (FOXM1)/eukaryotic elongation factor 2 kinase (eEF2K) axis as a molecular target in breast and other cancers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with EEF2K recombinant protein

 Reference Product  PubMed Publications
 EEF2 recombinant protein  >100 publications with EEF2K and EEF2

Pathways associated with EEF2K recombinant protein

 Products by Pathway  Pathway Diagram
 AMP-activated Protein Kinase (AMPK) Signaling Pathway antibodies  AMP-activated Protein Kinase (AMPK) Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 BDNF-TrkB Signaling Pathway antibodies  BDNF-TrkB Signaling Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Triggered By IGF1R Pathway antibodies  IRS-related Events Triggered By IGF1R Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram

Diseases associated with EEF2K recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >12 publications with EEF2K and Nervous System Diseases
 Disease Models, Animal Antibodies  >11 publications with EEF2K and Disease Models, Animal
 Hypertrophy Antibodies  >8 publications with EEF2K and Hypertrophy
 Cardiovascular Diseases Antibodies  >8 publications with EEF2K and Cardiovascular Diseases
 Atrophy Antibodies  >7 publications with EEF2K and Atrophy
 Depressive Disorder Antibodies  >6 publications with EEF2K and Depressive Disorder
 Inflammation Antibodies  >6 publications with EEF2K and Inflammation
 Hypertension Antibodies  >6 publications with EEF2K and Hypertension
 Neoplasms, Experimental Antibodies  >6 publications with EEF2K and Neoplasms, Experimental
 Necrosis Antibodies  >6 publications with EEF2K and Necrosis

Organs/Tissues associated with EEF2K recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >42 publications with EEF2K and Brain
 Muscle Antibodies  >30 publications with EEF2K and Muscle
 Heart Antibodies  >17 publications with EEF2K and Heart
 Blood Antibodies  >15 publications with EEF2K and Blood
 Liver Antibodies  >9 publications with EEF2K and Liver
 Kidney Antibodies  >7 publications with EEF2K and Kidney
 Lung Antibodies  >7 publications with EEF2K and Lung
 Pancreas Antibodies  >4 publications with EEF2K and Pancreas
 Intestine Antibodies  >2 publications with EEF2K and Intestine
 Bone Antibodies  >2 publications with EEF2K and Bone
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