COPE Recombinant Protein

Name: COPE Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205926
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205926

COPE is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential… More details

$230 / 0.004 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

COPE, Recombinant Protein

Full Product Name

COPE, 1-308aa, Human, His tag, E Coli

Product Gene Name

COPE recombinant protein

Product Synonym Names

Coatomer subunit epsilon; Coatomer subunit epsilon; Coatomer protein complex; subunit epsilon; epsilon-COP

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAPPAPG PASGGSGEVD ELFDVKNAFY IGSYQQCINE AQRVKLSSPE RDVERDVFLY RAYLAQRKFG VVLDEIKPSS APELQAVRMF ADYLAHESRR DSIVAELDRE MSRSVDVTNT TFLLMAASIY LHDQNPDAAL RALHQGDSLE CTAMTVQILL KLDRLDLARK ELKRMQDLDE DATLTQLATA WVSLATGGEK LQDAYYIFQE MADKCSPTLL LLNGQAACHM AQGRWEAAEG LLQEALDKDS GYPETLVNLI VLSQHLGKPP EVTNRYLSQL KDAHRSHPFI KEYQAKENDF DRLVLQYAPS A

Host

E Coli

Form/Format

Liquid, In Phosphate buffered saline (pH 7.4) containing 20% glycerol, 1mM DTT

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

36.9 kDa (331aa) confirmed by MALDI-TOF

OMIM

AJ131182 mRNA

3D Structure

ModBase 3D Structure for O14579

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for COPE recombinant protein

Signal Transduction

Applications Tested/Suitable for COPE recombinant protein

SDS-PAGE

Product References and Citations for COPE recombinant protein

Shima D.T., et al. (1999) Curr. Biol. 9:821-824

Other Notes

Small volumes of COPE recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COPE purchase

MBS205926 is a recombinant protein targeting COPE. Also known as COPE, 1-308aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for COPE. It may not necessarily be applicable to this product.

NCBI GI #

31542319

NCBI GeneID

11316

NCBI Accession #

NP_009194

UniProt Primary Accession #

O14579

UniProt Secondary Accession #

O76097; Q6IBB8; Q9UGP6; A6NE29; A6NKA3

UniProt Related Accession #

O14579

GenBank Nucleotide #

NM_007263.3

NCBI Official Full Name

coatomer subunit epsilon isoform a

NCBI Official Synonym Full Names

coatomer protein complex subunit epsilon

NCBI Official Symbol

COPE

NCBI Official Synonym Symbols

epsilon-COP

UniProt Protein Name

Coatomer subunit epsilon

UniProt Synonym Protein Names

Epsilon-coat protein; Epsilon-COP

Protein Family

Coatomer

UniProt Gene Name

COPE

UniProt Synonym Gene Names

Epsilon-COP

NCBI Protein Information

coatomer subunit epsilon

NCBI Summary for COPE

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for COPE

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors ().

Research Articles on COPE

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with COPE recombinant protein

Reference Product	PubMed Publications
COPA recombinant protein	>4 publications with COPE and COPA
ARF1 recombinant protein	>1 publications with COPE and ARF1
COPZ2 recombinant protein	>1 publications with COPE and COPZ2
COPG1 recombinant protein	>1 publications with COPE and COPG1
COPZ1 recombinant protein	>1 publications with COPE and COPZ1
COPB2 recombinant protein	>1 publications with COPE and COPB2

Pathways associated with COPE recombinant protein

Products by Pathway	Pathway Diagram
Asparagine N-linked Glycosylation Pathway antibodies	Asparagine N-linked Glycosylation Pathway Diagram
COPI-dependent Golgi-to-ER Retrograde Traffic Pathway antibodies	COPI-dependent Golgi-to-ER Retrograde Traffic Pathway Diagram
COPI-mediated Anterograde Transport Pathway antibodies	COPI-mediated Anterograde Transport Pathway Diagram
ER To Golgi Anterograde Transport Pathway antibodies	ER To Golgi Anterograde Transport Pathway Diagram
Golgi-to-ER Retrograde Transport Pathway antibodies	Golgi-to-ER Retrograde Transport Pathway Diagram
Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway antibodies	Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Transport To The Golgi And Subsequent Modification Pathway antibodies	Transport To The Golgi And Subsequent Modification Pathway Diagram

Diseases associated with COPE recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>16957 publications with COPE and Nervous System Diseases
Death Antibodies	>5745 publications with COPE and Death
Cardiovascular Diseases Antibodies	>5338 publications with COPE and Cardiovascular Diseases
Heart Diseases Antibodies	>2837 publications with COPE and Heart Diseases
Breast Neoplasms Antibodies	>2754 publications with COPE and Breast Neoplasms
Cognition Disorders Antibodies	>2381 publications with COPE and Cognition Disorders
Learning Disorders Antibodies	>1790 publications with COPE and Learning Disorders
Memory Disorders Antibodies	>1387 publications with COPE and Memory Disorders
Kidney Diseases Antibodies	>1093 publications with COPE and Kidney Diseases
Hypertension Antibodies	>812 publications with COPE and Hypertension

Organs/Tissues associated with COPE recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>16362 publications with COPE and Brain
Blood Antibodies	>5591 publications with COPE and Blood
Heart Antibodies	>4387 publications with COPE and Heart
Eye Antibodies	>4291 publications with COPE and Eye
Muscle Antibodies	>2173 publications with COPE and Muscle
Nerve Antibodies	>1858 publications with COPE and Nerve
Skin Antibodies	>1791 publications with COPE and Skin
Kidney Antibodies	>1437 publications with COPE and Kidney
Lung Antibodies	>1312 publications with COPE and Lung
Bone Antibodies	>1186 publications with COPE and Bone