• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

DBH Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205933

DBH also known as dopamine beta hydroxylase that catalyzes the chemical reaction. DBH belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated… More details

$245 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DBH, Recombinant Protein
Full Product Name
DBH, 40-617aa, Human, His tag, E Coli
Product Gene Name
DBH recombinant protein
Product Synonym Names
Dopamine beta hydroxylase; Dopamine beta hydroxylase; DBM
Sequence
MGSSHHHHHH SSGLVPRGSH MSAPRESPLP YHIPLDPEGS LELSWNVSYT QEAIHFQLLV RRLKAGVLFG MSDRGELENA DLVVLWTDGD TAYFADAWSD QKGQIHLDPQ QDYQLLQVQR TPEGLTLLFK RPFGTCDPKD YLIEDGTVHL VYGILEEPFR SLEAINGSGL QMGLQRVQLL KPNIPEPELP SDACTMEVQA PNIQIPSQET TYWCYIKELP KGFSRHHIIK YEPIVTKGNE ALVHHMEVFQ CAPEMDSVPH FSGPCDSKMK PDRLNYCRHV LAAWALGAKA FYYPEEAGLA FGGPGSSRYL RLEVHYHNPL VIEGRNDSSG IRLYYTAKLR RFNAGIMELG LVYTPVMAIP PRETAFILTG YCTDKCTQLA LPPSGIHIFA SQLHTHLTGR KVVTVLVRDG REWEIVNQDN HYSPHFQEIR MLKKVVSVHP GDVLITSCTY NTEDRELATV GGFGILEEMC VNYVHYYPQT QLELCKSAVD AGFLQKYFHL INRFNNEDVC TCPQASVSQQ FTSVPWNSFN RDVLKALYSF APISMHCNKS SAVRFQGEWN LQPLPKVIST LEEPTPQCPT SQGRSPAGPT VVSIGGGKG
Host
E Coli
Form/Format
Liquid, In Phosphate buffered saline (pH 7.4) containing 10% glycerol, 1mM DTT
Purity/Purification
> 85% by SDS-PAGE
Concentration
0.25mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
67.2kDa (599aa)
OMIM
AL365494 Genomic DNA
3D Structure
ModBase 3D Structure for P09172
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for DBH recombinant protein

Neuroscience
Applications Tested/Suitable for DBH recombinant protein
SDS-PAGE

SDS-Page of DBH recombinant protein

DBH Recombinant Protein – Cat# MBS205933

Product References and Citations for DBH recombinant protein

Rush RA.,et al. (1980) Crit Rev Clin Lab Sci. 12 (3): 241-77

Other Notes

Small volumes of DBH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DBH purchase

MBS205933 is a recombinant protein targeting DBH. Also known as DBH, 40-617aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DBH. It may not necessarily be applicable to this product.

NCBI GI #
116534900
NCBI GeneID
1621
NCBI Accession #
NP_000778
UniProt Primary Accession #
P09172
UniProt Secondary Accession #
Q5T381; Q96AG2
UniProt Related Accession #
P09172
GenBank Nucleotide #
NM_000787.3
NCBI Official Full Name
dopamine beta-hydroxylase
NCBI Official Synonym Full Names
dopamine beta-hydroxylase
NCBI Official Symbol
DBH
NCBI Official Synonym Symbols
DBM
UniProt Protein Name
Dopamine beta-hydroxylase
UniProt Synonym Protein Names
Dopamine beta-monooxygenase
Protein Family
Dopamine beta-hydroxylase
UniProt Gene Name
DBH
NCBI Protein Information
dopamine beta-hydroxylase

NCBI Summary for DBH

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]
Show more

UniProt Comments for DBH

Conversion of dopamine to noradrenaline.

Research Articles on DBH

1. This study indicated that DBH5'-Ins/Del polymorphism may not play a role in the susceptibility to tardive dyskinesia and cognitive deficits in schizophrenia with tardive dyskinesia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DBH recombinant protein

 Reference Product  PubMed Publications
 PNMT recombinant protein  >193 publications with DBH and PNMT
 NPY recombinant protein  >125 publications with DBH and NPY
 COMT recombinant protein  >93 publications with DBH and COMT
 DDC recombinant protein  >43 publications with DBH and DDC
 MAOA recombinant protein  >32 publications with DBH and MAOA
 MAOB recombinant protein  >8 publications with DBH and MAOB
 CYB561 recombinant protein  >2 publications with DBH and CYB561

Pathways associated with DBH recombinant protein

 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Amino Acid Metabolism Pathway antibodies  Amino Acid Metabolism Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Catecholamine Biosynthesis Pathway antibodies  Catecholamine Biosynthesis Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram

Diseases associated with DBH recombinant protein

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >282 publications with DBH and Mental Disorders
 Nervous System Diseases Antibodies  >232 publications with DBH and Nervous System Diseases
 Hypertension Antibodies  >99 publications with DBH and Hypertension
 Movement Disorders Antibodies  >68 publications with DBH and Movement Disorders
 Disease Models, Animal Antibodies  >58 publications with DBH and Disease Models, Animal
 Heart Diseases Antibodies  >53 publications with DBH and Heart Diseases
 Neuroblastoma Antibodies  >49 publications with DBH and Neuroblastoma
 Hypotension Antibodies  >46 publications with DBH and Hypotension
 Pheochromocytoma Antibodies  >42 publications with DBH and Pheochromocytoma
 Depressive Disorder Antibodies  >39 publications with DBH and Depressive Disorder

Organs/Tissues associated with DBH recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >654 publications with DBH and Brain
 Nerve Antibodies  >395 publications with DBH and Nerve
 Adrenal Gland Antibodies  >230 publications with DBH and Adrenal Gland
 Ganglia Antibodies  >168 publications with DBH and Ganglia
 Embryonic Tissue Antibodies  >30 publications with DBH and Embryonic Tissue
 Mouth Antibodies  >16 publications with DBH and Mouth
 Testis Antibodies  >7 publications with DBH and Testis
 Lymph Node Antibodies  >5 publications with DBH and Lymph Node
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000