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SPINT2 Baculovirus Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205989

SPINT2, also known as kunitz-type protease inhibitor 2, inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This protein has been identified as a putative tumor suppressor gene silenced by promoter methylation. Recombinant… More details

$245 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SPINT2, Recombinant Protein
Full Product Name
SPINT2, 28-197aa, Human, His tag, Baculovirus
Product Synonym Names
Kunitz-type protease inhibitor 2; DIAR3; HAI-2; HAI2; Kop; PB
Sequence
ADRERSIHDF CLVSKVVGRC RASMPRWWYN VTDGSCQLFV YGGCDGNSNN YLTKEECLKK CATVTENATG DLATSRNAAD SSVPSAPRRQ DSEDHSSDMF NYEEYCTANA VTGPCRASFP RWYFDVERNS CNNFIYGGCR GNKNSYRSEE ACMLRCFRQQ ENPPLPLGSK HHHHHH
Host
Baculovirus
Form/Format
Liquid. In phosphate buffered saline (pH 7.4), 10% glycerol.
Purity/Purification
> 80% by SDS-PAGE
Concentration
0.2mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
20kDa (176aa) 18-28KDa (SDS-PAGE under reducing conditions.)
OMIM
AB006534 mRNA
3D Structure
ModBase 3D Structure for O43291
Antigen Species
Human
Tag Information
His-tag
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for SPINT2 recombinant protein

Applications Tested/Suitable for SPINT2 recombinant protein
SDS-PAGE

Product References and Citations for SPINT2 recombinant protein

Heinz-Erian P, et al (2009) Am J Hum Genet. 84 (2):188-96. ; Muller-Pillasch F, et al (1998) Biochim Biophys Acta. 1395 (1):88-95.; Yue D, et al (2014) Exp Cell Res. 322 (1):149-58.;

Other Notes

Small volumes of SPINT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPINT2 purchase

MBS205989 is a recombinant protein targeting SPINT2. Also known as SPINT2, 28-197aa, Human, His tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for SPINT2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
kunitz-type protease inhibitor 2 isoform a
NCBI Official Synonym Full Names
serine peptidase inhibitor, Kunitz type 2
NCBI Official Symbol
SPINT2
NCBI Official Synonym Symbols
PB; Kop; HAI2; DIAR3; HAI-2
UniProt Protein Name
Kunitz-type protease inhibitor 2
UniProt Synonym Protein Names
Hepatocyte growth factor activator inhibitor type 2; HAI-2; Placental bikunin
UniProt Gene Name
SPINT2
UniProt Synonym Gene Names
HAI2; KOP; HAI-2
NCBI Protein Information
kunitz-type protease inhibitor 2

NCBI Summary for SPINT2

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
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UniProt Comments for SPINT2

Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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