IFNL1 Recombinant Protein

Name: IFNL1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS206044
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206044

IFNL1 also known as Interferon lambda-1. This protein is cytokine with immunomodulatory activity and may play a role in antiviral immunity. It is ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IFNL1, Recombinant Protein

Full Product Name

IFNL1, 20-200aa, Human, His tag, E Coli (Denatured)

Product Gene Name

IFNL1 recombinant protein

Product Synonym Names

Interferon lambda-1; IL-29; IL29

Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMGPVPT SKPTTTGKGC HIGRFKSLSP QELASFKKAR DALEESLKLK NWSCSSPVFP GNWDLRLLQV RERPVALEAE LALTLKVLEA AAGPALEDVL DQPLHTLHHI LSQLQACIQP QPTAGPRPRG RLHHWLHRLQ EAPKKESAGC LEASVTFNLF RLLTRDLKYV ADGNLCLRTS THPEST

Host

E Coli

Form/Format

Liquid, In 20mM Tris-HCl (pH 8.0) containing 10% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

1mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

22.7kDa (206aa)

OMIM

AY129150 mRNA

3D Structure

ModBase 3D Structure for Q8IU54

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for IFNL1 recombinant protein

Hormones & Cytokines

Applications Tested/Suitable for IFNL1 recombinant protein

SDS-PAGE

Application Notes for IFNL1 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for IFNL1 recombinant protein

Kotenko S.V., et al. (2003) Nat. Immunol, 4:69-77

Other Notes

Small volumes of IFNL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNL1 purchase

MBS206044 is a recombinant protein targeting IFNL1. Also known as IFNL1, 20-200aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNL1. It may not necessarily be applicable to this product.

NCBI GI #

26024325

NCBI GeneID

282618

NCBI Accession #

NP_742152

UniProt Primary Accession #

Q8IU54

UniProt Secondary Accession #

Q17R34; A0AV25

UniProt Related Accession #

Q8IU54

GenBank Nucleotide #

NM_172140.1

NCBI Official Full Name

interferon lambda-1

NCBI Official Synonym Full Names

interferon lambda 1

NCBI Official Symbol

IFNL1

NCBI Official Synonym Symbols

IL29; IL-29

UniProt Protein Name

Interferon lambda-1

UniProt Synonym Protein Names

Cytokine Zcyto21; Interleukin-29; IL-29

Protein Family

Interferon

UniProt Gene Name

IFNL1

UniProt Synonym Gene Names

IL29; ZCYTO21; IFN-lambda-1; IL-29

NCBI Protein Information

interferon lambda-1

NCBI Summary for IFNL1

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

UniProt Comments for IFNL1

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Research Articles on IFNL1

1. The review focuses on the value of the type I and III interferon subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFNL1 recombinant protein

Reference Product	PubMed Publications
IL29 recombinant protein	>5 publications with IFNL1 and IL29

Pathways associated with IFNL1 recombinant protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Signaling By Interleukins Pathway antibodies	Signaling By Interleukins Pathway Diagram
Type III Interferon Signaling Pathway antibodies	Type III Interferon Signaling Pathway Diagram

Diseases associated with IFNL1 recombinant protein

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>1 publications with IFNL1 and Adenocarcinoma
Liver Cirrhosis Antibodies	>1 publications with IFNL1 and Liver Cirrhosis
Leukemia Antibodies	>1 publications with IFNL1 and Leukemia
Liver Failure Antibodies	>1 publications with IFNL1 and Liver Failure