IFIT3 Recombinant Protein

Name: IFIT3 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS206045
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206045

IFIT3 also known as Interferon-induced protein with tetratricopeptiede repeats 3 isoform a. IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. IFIT3… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IFIT3, Recombinant Protein

Full Product Name

IFIT3, 1-490aa, Human, His tag, E Coli

Product Gene Name

IFIT3 recombinant protein

Product Synonym Names

Interferon-induced protein with tetratricopeptiede repeats 3 isoform a; CIG-49; GARG-49; IFI60; IFIT4; IRG2; ISG60; P60; RIG-G

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSEVTKN SLEKILPQLK CHFTWNLFKE DSVSRDLEDR VCNQIEFLNT EFKATMYNLL AYIKHLDGNN EAALECLRQA EELIQQEHAD QAEIRSLVTW GNYAWVYYHL GRLSDAQIYV DKVKQTCKKF SNPYSIEYSE LDCEEGWTQL KCGRNERAKV CFEKALEEKP NNPEFSSGLA IAMYHLDNHP EKQFSTDVLK QAIELSPDNQ YVKVLLGLKL QKMNKEAEGE QFVEEALEKS PCQTDVLRSA AKFYRRKGDL DKAIELFQRV LESTPNNGYL YHQIGCCYKA KVRQMQNTGE SEASGNKEMI EALKQYAMDY SNKALEKGLN PLNAYSDLAE FLETECYQTP FNKEVPDAEK QQSHQRYCNL QKYNGKSEDT AVQHGLEGLS ISKKSTDKEE IKDQPQNVSE NLLPQNAPNY WYLQGLIHKQ NGDLLQAAKC YEKELGRLLR DAPSGIGSIF LSASELEDGS EEMGQGAVSS SPRELLSNSE QLN

Host

E Coli

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 20% glycerol, 1mM DTT

Purity/Purification

> 80% by SDS-PAGE

Concentration

1mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

58.4kDa (513aa)

OMIM

AF026939 mRNA

3D Structure

ModBase 3D Structure for O14879

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for IFIT3 recombinant protein

Immunology

Applications Tested/Suitable for IFIT3 recombinant protein

SDS-PAGE

Product References and Citations for IFIT3 recombinant protein

Fensterl V., et al. (2011) J. Interferon Cytokine Res. 31:71-78.; Liu X.Y., et al. (2011) J. Immunol. 187:2559-2568.;

Other Notes

Small volumes of IFIT3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFIT3 purchase

MBS206045 is a recombinant protein targeting IFIT3. Also known as IFIT3, 1-490aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IFIT3. It may not necessarily be applicable to this product.

NCBI GI #

31542980

NCBI GeneID

3437

NCBI Accession #

NP_001540

UniProt Primary Accession #

O14879

UniProt Secondary Accession #

Q99634; Q9BSK7

UniProt Related Accession #

O14879

GenBank Nucleotide #

NM_001549.5

NCBI Official Full Name

interferon-induced protein with tetratricopeptide repeats 3 isoform a

NCBI Official Synonym Full Names

interferon induced protein with tetratricopeptide repeats 3

NCBI Official Symbol

IFIT3

NCBI Official Synonym Symbols

P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49

UniProt Protein Name

Interferon-induced protein with tetratricopeptide repeats 3

UniProt Synonym Protein Names

CIG49; ISG-60; Interferon-induced 60 kDa protein; IFI-60K; Interferon-induced protein with tetratricopeptide repeats 4; IFIT-4; Retinoic acid-induced gene G protein; P60; RIG-G

Protein Family

Interferon-induced protein with tetratricopeptide repeats

UniProt Gene Name

IFIT3

UniProt Synonym Gene Names

CIG-49; IFI60; IFIT4; ISG60; IFIT-3; IFI-60K; IFIT-4; P60; RIG-G

NCBI Protein Information

interferon-induced protein with tetratricopeptide repeats 3

UniProt Comments for IFIT3

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

Research Articles on IFIT3

1. these data suggest that postpartum, the normalization of the physiological rheostat controlling IFN signaling depends on IFNL3 genotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFIT3 recombinant protein

Reference Product	PubMed Publications
IFIT1 recombinant protein	>51 publications with IFIT3 and IFIT1
IFIT2 recombinant protein	>37 publications with IFIT3 and IFIT2
MX1 recombinant protein	>21 publications with IFIT3 and MX1
ISG15 recombinant protein	>15 publications with IFIT3 and ISG15
RSAD2 recombinant protein	>9 publications with IFIT3 and RSAD2
OAS1 recombinant protein	>6 publications with IFIT3 and OAS1
OASL recombinant protein	>4 publications with IFIT3 and OASL
IFI35 recombinant protein	>2 publications with IFIT3 and IFI35
OAS3 recombinant protein	>2 publications with IFIT3 and OAS3
OAS2 recombinant protein	>2 publications with IFIT3 and OAS2

Pathways associated with IFIT3 recombinant protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram
Interferon Alpha/beta Signaling Pathway antibodies	Interferon Alpha/beta Signaling Pathway Diagram

Diseases associated with IFIT3 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>14 publications with IFIT3 and Inflammation
Death Antibodies	>8 publications with IFIT3 and Death
Nervous System Diseases Antibodies	>8 publications with IFIT3 and Nervous System Diseases
Liver Diseases Antibodies	>7 publications with IFIT3 and Liver Diseases
Adenocarcinoma Antibodies	>6 publications with IFIT3 and Adenocarcinoma
Necrosis Antibodies	>5 publications with IFIT3 and Necrosis
Influenza, Human Antibodies	>3 publications with IFIT3 and Influenza, Human
Lung Injury Antibodies	>2 publications with IFIT3 and Lung Injury
Carcinoma, Hepatocellular Antibodies	>2 publications with IFIT3 and Carcinoma, Hepatocellular
Lung Diseases Antibodies	>2 publications with IFIT3 and Lung Diseases

Organs/Tissues associated with IFIT3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>30 publications with IFIT3 and Blood
Brain Antibodies	>9 publications with IFIT3 and Brain
Lung Antibodies	>7 publications with IFIT3 and Lung
Vascular Antibodies	>5 publications with IFIT3 and Vascular
Connective Tissue Antibodies	>3 publications with IFIT3 and Connective Tissue
Lymph Node Antibodies	>2 publications with IFIT3 and Lymph Node
Skin Antibodies	>2 publications with IFIT3 and Skin
Mouth Antibodies	>2 publications with IFIT3 and Mouth
Muscle Antibodies	>2 publications with IFIT3 and Muscle
Intestine Antibodies	>1 publications with IFIT3 and Intestine