HADHB Recombinant Protein

Name: HADHB Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS206118
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206118

HADHB is the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HADHB, Recombinant Protein

Full Product Name

HADHB, 34-474aa, Human, His tag, E Coli (Denatured)

Product Gene Name

HADHB recombinant protein

Product Synonym Names

Trifunctional enzyme subunit beta mitochondrial; Trifunctional enzyme subunit beta; mitochondrial; ECHB; MSTP029; MTPB; TP-BETA

Sequence

MGSSHHHHHH SSGLVPRGSH MGSAAPAVQT KTKKTLAKPN IRNVVVVDGV RTPFLLSGTS YKDLMPHDLA RAALTGLLHR TSVPKEVVDY IIFGTVIQEV KTSNVAREAA LGAGFSDKTP AHTVTMACIS ANQAMTTGVG LIASGQCDVI VAGGVELMSD VPIRHSRKMR KLMLDLNKAK SMGQRLSLIS KFRFNFLAPE LPAVSEFSTS ETMGHSADRL AAAFAVSRLE QDEYALRSHS LAKKAQDEGL LSDVVPFKVP GKDTVTKDNG IRPSSLEQMA KLKPAFIKPY GTVTAANSSF LTDGASAMLI MAEEKALAMG YKPKAYLRDF MYVSQDPKDQ LLLGPTYATP KVLEKAGLTM NDIDAFEFHE AFSGQILANF KAMDSDWFAE NYMGRKTKVG LPPLEKFNNW GGSLSLGHPF GATGCRLVMA AANRLRKEGG QYGLVAACAA GGQGHAMIVE AYPK

Host

E Coli

Form/Format

Liquid, In 20mM phosphate (pH 8.0) containing 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles

Molecular Weight

49.9 kDa (464aa)

OMIM

D16481 mRNA

3D Structure

ModBase 3D Structure for P55084

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for HADHB recombinant protein

Metabolism

Applications Tested/Suitable for HADHB recombinant protein

SDS-PAGE

Application Notes for HADHB recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for HADHB recombinant protein

Purevsuren J., et al. (2009) Mol Genet Metab, PMID 19699128

Other Notes

Small volumes of HADHB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HADHB purchase

MBS206118 is a recombinant protein targeting HADHB. Also known as HADHB, 34-474aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HADHB. It may not necessarily be applicable to this product.

NCBI GI #

4504327

NCBI GeneID

3032

NCBI Accession #

NP_000174

UniProt Primary Accession #

P55084

UniProt Secondary Accession #

O14969; Q53TA6; Q96C77; Q9H3F5; Q9T2V8; B2RB16; B4E2W0

UniProt Related Accession #

P55084

GenBank Nucleotide #

NM_000183.2

NCBI Official Full Name

trifunctional enzyme subunit beta, mitochondrial isoform 1

NCBI Official Synonym Full Names

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

NCBI Official Symbol

HADHB

NCBI Official Synonym Symbols

ECHB; MTPB; MSTP029; TP-BETA

UniProt Protein Name

Trifunctional enzyme subunit beta, mitochondrial

UniProt Synonym Protein Names

TP-betaIncluding the following 1 domains:3-ketoacyl-CoA thiolase (EC:2.3.1.16)Alternative name(s):Acetyl-CoA acyltransferase; Beta-ketothiolase

Protein Family

Trifunctional enzyme

UniProt Gene Name

HADHB

NCBI Protein Information

trifunctional enzyme subunit beta, mitochondrial

NCBI Summary for HADHB

This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

Research Articles on HADHB

1. Exposure to bezafibrate (400 muM for 48 h) increased the abundance of HADHA and HADHB mRNAs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HADHB recombinant protein

Reference Product	PubMed Publications
HADHA recombinant protein	>25 publications with HADHB and HADHA
ACADS recombinant protein	>2 publications with HADHB and ACADS
ACADM recombinant protein	>2 publications with HADHB and ACADM
EHHADH recombinant protein	>2 publications with HADHB and EHHADH
ACADVL recombinant protein	>1 publications with HADHB and ACADVL
HMGCS1 recombinant protein	>1 publications with HADHB and HMGCS1

Pathways associated with HADHB recombinant protein

Products by Pathway	Pathway Diagram
Acyl Chain Remodeling Of CL Pathway antibodies	Acyl Chain Remodeling Of CL Pathway Diagram
Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway antibodies	Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway Diagram
Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway antibodies	Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway Diagram
Beta Oxidation Of Lauroyl-CoA To Decanoyl-CoA-CoA Pathway antibodies	Beta Oxidation Of Lauroyl-CoA To Decanoyl-CoA-CoA Pathway Diagram
Beta Oxidation Of Myristoyl-CoA To Lauroyl-CoA Pathway antibodies	Beta Oxidation Of Myristoyl-CoA To Lauroyl-CoA Pathway Diagram
Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway antibodies	Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway Diagram
Beta Oxidation Of Palmitoyl-CoA To Myristoyl-CoA Pathway antibodies	Beta Oxidation Of Palmitoyl-CoA To Myristoyl-CoA Pathway Diagram
Fatty Acid Beta Oxidation Pathway antibodies	Fatty Acid Beta Oxidation Pathway Diagram
Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway antibodies	Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway Diagram
Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway antibodies	Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway Diagram

Diseases associated with HADHB recombinant protein

Disease Name	Pubmed Publications
Lipid Metabolism Disorders Antibodies	>13 publications with HADHB and Lipid Metabolism Disorders
Fatty Liver Antibodies	>13 publications with HADHB and Fatty Liver
Liver Diseases Antibodies	>9 publications with HADHB and Liver Diseases
Cardiovascular Diseases Antibodies	>8 publications with HADHB and Cardiovascular Diseases
Trifunctional Protein Deficiency With Myopathy And Neuropathy Antibodies	>6 publications with HADHB and Trifunctional Protein Deficiency With Myopathy And Neuropathy
Heart Diseases Antibodies	>6 publications with HADHB and Heart Diseases
Insulin Resistance Antibodies	>3 publications with HADHB and Insulin Resistance
Inflammation Antibodies	>3 publications with HADHB and Inflammation
Disease Models, Animal Antibodies	>3 publications with HADHB and Disease Models, Animal
Weight Gain Antibodies	>3 publications with HADHB and Weight Gain

Organs/Tissues associated with HADHB recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>18 publications with HADHB and Liver
Muscle Antibodies	>13 publications with HADHB and Muscle
Blood Antibodies	>9 publications with HADHB and Blood
Heart Antibodies	>8 publications with HADHB and Heart
Connective Tissue Antibodies	>4 publications with HADHB and Connective Tissue
Adipose Tissue Antibodies	>4 publications with HADHB and Adipose Tissue
Nerve Antibodies	>4 publications with HADHB and Nerve
Brain Antibodies	>4 publications with HADHB and Brain
Vascular Antibodies	>3 publications with HADHB and Vascular
Skin Antibodies	>2 publications with HADHB and Skin