PSMD5 Recombinant Protein

Name: PSMD5 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS206167
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206167

PSMD5 also known as 26S proteasome non-ATPase regulatory subunit 5 isoform 1. The 26S proteasome is an enzymatic complex that degrades ubiquitinated proteins in eukaryotic cells. PSMD5 is one of a number of chaperones that are involved in the assembly of the… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PSMD5, Recombinant Protein

Full Product Name

PSMD5, 1-504aa, Human, His tag, E Coli

Product Gene Name

PSMD5 recombinant protein

Product Synonym Names

26S proteasome non-ATPase regulatory subunit 5 isoform 1

Sequence

MGSSHHHHHH SSGLVPRGSH MGSEFMAAQA LALLREVARL EAPLEELRAL HSVLQAVPLN ELRQQAAELR LGPLFSLLNE NHREKTTLCV SILERLLQAM EPVHVARNLR VDLQRGLIHP DDSVKILTLS QIGRIVENSD AVTEILNNAE LLKQIVYCIG GENLSVAKAA IKSLSRISLT QAGLEALFES NLLDDLKSVM KTNDIVRYRV YELIIEISSV SPESLNYCTT SGLVTQLLRE LTGEDVLVRA TCIEMVTSLA YTHHGRQYLA QEGVIDQISN IIVGADSDPF SSFYLPGFVK FFGNLAVMDS PQQICERYPI FVEKVFEMIE SQDPTMIGVA VDTVGILGSN VEGKQVLQKT GTRFERLLMR IGHQSKNAPV ELKIRCLDAI SSLLYLPPEQ QTDDLLRMTE SWFSSLSRDP LELFRGISSQ PFPELHCAAL KVFTAIANQP WAQKLMFNSP GFVEYVVDRS VEHDKASKDA KYELVKALAN SKTIAEIFGN PNYLRLRTYL SEGPYYVKPV STTAVEGAE

Host

E Coli

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

58.9kDa (529aa)

OMIM

S79862 mRNA

3D Structure

ModBase 3D Structure for Q16401

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for PSMD5 recombinant protein

Ubiquitination

Applications Tested/Suitable for PSMD5 recombinant protein

SDS-PAGE

Product References and Citations for PSMD5 recombinant protein

Kaneko T., et al. (2009) Cell. 137 (5):914-925.; Shim SM., et al. (2012) Cell. 2 (3):603-615

Other Notes

Small volumes of PSMD5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSMD5 purchase

MBS206167 is a recombinant protein targeting PSMD5. Also known as PSMD5, 1-504aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PSMD5. It may not necessarily be applicable to this product.

NCBI GI #

4826952

NCBI GeneID

5711

NCBI Accession #

NP_005038

UniProt Primary Accession #

Q16401

UniProt Secondary Accession #

Q15045; Q4VXG8; B4DZM8

UniProt Related Accession #

Q16401

GenBank Nucleotide #

NM_005047.3

NCBI Official Full Name

26S proteasome non-ATPase regulatory subunit 5 isoform 1

NCBI Official Synonym Full Names

proteasome 26S subunit, non-ATPase 5

NCBI Official Symbol

PSMD5

NCBI Official Synonym Symbols

S5B

UniProt Protein Name

26S proteasome non-ATPase regulatory subunit 5

UniProt Synonym Protein Names

26S protease subunit S5 basic; 26S proteasome subunit S5B

Protein Family

26S proteasome non-ATPase regulatory

UniProt Gene Name

PSMD5

UniProt Synonym Gene Names

KIAA0072

NCBI Protein Information

26S proteasome non-ATPase regulatory subunit 5

NCBI Summary for PSMD5

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]

UniProt Comments for PSMD5

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.

Research Articles on PSMD5

1. the critical role of S5b/PSMD5 in negative regulation of proteasome by TNF-alpha/NFkappaB and provide insights into proteasome inhibition in human disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PSMD5 recombinant protein

Products by Pathway	Pathway Diagram
ABC Transporter Disorders Pathway antibodies	ABC Transporter Disorders Pathway Diagram
ABC-family Proteins Mediated Transport Pathway antibodies	ABC-family Proteins Mediated Transport Pathway Diagram
APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies	APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies	APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies	APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway antibodies	AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway Diagram
Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram

Diseases associated with PSMD5 recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>1 publications with PSMD5 and Necrosis

Organs/Tissues associated with PSMD5 recombinant protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>1 publications with PSMD5 and Eye