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Leucine-Rich Repeat Transmembrane Protein FLRT2 (FLRT2) Baculovirus Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206176

FLRT2, also known as leucine-rich repeat transmembrane protein FLRT2, is one of three FLRT (fibronectin, leucine rich repeat, transmembrane) glycoproteins expressed in distinct areas of the developing brain and other tissues. Human FLRT1 and FLRT3 ECDs… More details

$365 / 0.01 mg +1 FREE 8GB USB
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Leucine-rich repeat transmembrane protein FLRT2, Recombinant Protein
Full Product Name
Leucine-rich repeat transmembrane protein FLRT2, 36-541aa, Human, His tag, Baculovirus
Product Gene Name
FLRT2 recombinant protein
Product Synonym Names
FLRT2
Sequence
CPSVCRCDRN FVYCNERSLT SVPLGIPEGV TVLYLHNNQI NNAGFPAELH NVQSVHTVYL YGNQLDEFPM NLPKNVRVLH LQENNIQTIS RAALAQLLKL EELHLDDNSI STVGVEDGAF REAISLKLLF LSKNHLSSVP VGLPVDLQEL RVDENRIAVI SDMAFQNLTS LERLIVDGNL LTNKGIAEGT FSHLTKLKEF SIVRNSLSHP PPDLPGTHLI RLYLQDNQIN HIPLTAFSNL RKLERLDISN NQLRMLTQGV FDNLSNLKQL TARNNPWFCD CSIKWVTEWL KYIPSSLNVR GFMCQGPEQV RGMAVRELNM NLLSCPTTTP GLPLFTPAPS TASPTTQPPT LSIPNPSRSY TPPTPTTSKL PTIPDWDGRE RVTPPISERI QLSIHFVNDT SIQVSWLSLF TVMAYKLTWV KMGHSLVGGI VQERIVSGEK QHLSLVNLEP RSTYRICLVP LDAFNYRAVE DTICSEATTH ASYLNNGSNT ASSHEQTTSH SMGSPFLEHH HHHH
Host
Baculovirus
Form/Format
Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.25mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
57.5kDa (514aa) 50-70KDa (SDS-PAGE under reducing conditions.)
OMIM
AF169676 mRNA
3D Structure
ModBase 3D Structure for O43155
Antigen Species
Human
Tag Information
His-tag
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for FLRT2 recombinant protein

Signal Transduction; Hormones & Cytokines
Applications Tested/Suitable for FLRT2 recombinant protein
SDS-PAGE

SDS-Page of FLRT2 recombinant protein

Baculovirus FLRT2 Recombinant Protein – Cat# MBS206176

Product References and Citations for FLRT2 recombinant protein

Haines B.P., et al. (2006) Dev. Biol. 297:14-25.; Lacy S.E., et al. (1999) Genomics. 62:417-426.

Other Notes

Small volumes of FLRT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FLRT2 purchase

MBS206176 is a recombinant protein targeting FLRT2. Also known as Leucine-rich repeat transmembrane protein FLRT2, 36-541aa, Human, His tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for FLRT2. It may not necessarily be applicable to this product.

NCBI GI #
7019381
NCBI GeneID
23768
NCBI Accession #
NP_037363
UniProt Primary Accession #
O43155
UniProt Secondary Accession #
A0AV84; B7ZLP3
UniProt Related Accession #
O43155
GenBank Nucleotide #
NM_013231.5
NCBI Official Full Name
leucine-rich repeat transmembrane protein FLRT2
NCBI Official Synonym Full Names
fibronectin leucine rich transmembrane protein 2
NCBI Official Symbol
FLRT2
UniProt Protein Name
Leucine-rich repeat transmembrane protein FLRT2
UniProt Synonym Protein Names
Fibronectin-like domain-containing leucine-rich transmembrane protein 2
Protein Family
Leucine-rich repeat transmembrane protein
UniProt Gene Name
FLRT2
UniProt Synonym Gene Names
KIAA0405
NCBI Protein Information
leucine-rich repeat transmembrane protein FLRT2

NCBI Summary for FLRT2

This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
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UniProt Comments for FLRT2

Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
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Research Articles on FLRT2

1. OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FLRT2 recombinant protein

 Products by Pathway  Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By FGFR Pathway antibodies  Signaling By FGFR Pathway Diagram
 Signaling By FGFR1 Pathway antibodies  Signaling By FGFR1 Pathway Diagram

Diseases associated with FLRT2 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >2 publications with FLRT2 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >2 publications with FLRT2 and Lung Neoplasms
 Lung Diseases Antibodies  >2 publications with FLRT2 and Lung Diseases
 Nervous System Diseases Antibodies  >1 publications with FLRT2 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with FLRT2 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >1 publications with FLRT2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >1 publications with FLRT2 and Heart Diseases
 Anemia Antibodies  >1 publications with FLRT2 and Anemia
 Liver Neoplasms Antibodies  >1 publications with FLRT2 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with FLRT2 and Liver Diseases

Organs/Tissues associated with FLRT2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with FLRT2 and Brain
 Embryonic Tissue Antibodies  >4 publications with FLRT2 and Embryonic Tissue
 Heart Antibodies  >3 publications with FLRT2 and Heart
 Liver Antibodies  >2 publications with FLRT2 and Liver
 Eye Antibodies  >2 publications with FLRT2 and Eye
 Muscle Antibodies  >2 publications with FLRT2 and Muscle
 Bone Antibodies  >2 publications with FLRT2 and Bone
 Pancreas Antibodies  >1 publications with FLRT2 and Pancreas
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