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CTLA4 Baculovirus Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206243

CTLA4, also known as cytotoxic T-lymphocyte protein 4 isoform 1, is a type 1 membrane protein and a member of the immunoglobulin-superfamily. Besides, this protein contains an extra cellular domain, a transmembrane domain and a cytoplasmic tail. It is… More details

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Product Overview

Product Name
Ctla4, Recombinant Protein
Full Product Name
Ctla4, 38-161aa, Mouse, hIgG-His tag, Baculovirus
Product Gene Name
Product Synonym Names
Cytotoxic T-lymphocyte protein 4 isoform 1; CTLA4; Cd152; Ctla-4; Ly-56
Sequence
IQVTQPSVVL ASSHGVASFP CEYSPSHNTD EVRVTVLRQT NDQMTEVCAT TFTEKNTVGF LDYPFCSGTF NESRVNLTIQ GLRAVDTGLY LCKVELMYPP PYFVGMGNGT QIYVIDPEPC PDSDLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH
Host
Baculovirus
Form/Format
Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
40.6kDa (363aa) 40-57KDa (SDS-PAGE under reducing conditions.)
3D Structure
ModBase 3D Structure for P09793
Antigen Species
Mouse
Tag Information
hIgG-His-tag
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for Ctla4 recombinant protein

Applications Tested/Suitable for Ctla4 recombinant protein
SDS-PAGE

Product References and Citations for Ctla4 recombinant protein

Krummey SM., et al. (2014) J. Immunol. 192:2495-2504.; Jain N., et al. (2013) Nat. Med. 19:1632-1637.; Yu CR., et al. (2013) J. Immunol. 191:5036-5043.

Other Notes

Small volumes of Ctla4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ctla4 purchase

MBS206243 is a recombinant protein targeting Ctla4. Also known as Ctla4, 38-161aa, Mouse, hIgG-His tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for Ctla4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cytotoxic T-lymphocyte protein 4 isoform 1
NCBI Official Synonym Full Names
cytotoxic T-lymphocyte-associated protein 4
NCBI Official Symbol
Ctla4
NCBI Official Synonym Symbols
Cd152; Ly-56; Ctla-4
UniProt Protein Name
Cytotoxic T-lymphocyte protein 4
UniProt Synonym Protein Names
Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD_antigen: CD152
UniProt Gene Name
Ctla4
UniProt Synonym Gene Names
Cd152; CTLA-4
NCBI Protein Information
cytotoxic T-lymphocyte protein 4

NCBI Summary for Ctla4

This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

UniProt Comments for Ctla4

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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