• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

LDLR Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206270

MESDC2 also known as LDLR chaperone MESD. This protein is specialized chaperone for low-density lipoprotein receptor-related protein 5 and LRP6. MESDC2 binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1 to LRP6.… More details

$230 / 0.004 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LDLR, Recombinant Protein
Full Product Name
LDLR chaperone MESD, 30-224aa, Mouse, His tag, E Coli
Product Gene Name
Product Synonym Names
2210015O11Rik; AW537813; mesd; mKIAA0081; msd
Sequence
MGSSHHHHHH SSGLVPRGSH MGSADTPGEA TPPPRKKKDI RDYNDADMAR LLEQWEKDDD IEEGDLPEHK RPSAPIDFSK LDPGKPESIL KMTKKGKTLM MFVTVSGNPT EKETEEITSL WQGSLFNANY DVQRFIVGSD RAIFMLRDGS YAWEIKDFLV SQDRCAEVTL EGQMYPGKGG GSKEKNKTKP EKAKKKEGDP KPRASKEDNR AGSRREDL
Host
E Coli
Form/Format
Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
1mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
24.4kDa (218aa)
3D Structure
ModBase 3D Structure for Q9ERE7
Antigen Species
Mouse
Tag Information
His-tag
Applications Tested/Suitable for LDLR recombinant protein
SDS-PAGE

Product References and Citations for LDLR recombinant protein

Lu W., et al. (2010) Biochemistry. 49 (22): 4635-43.; Hoshi T., et al. (2013) FEBS Lett. 587 (23): 3749-54.

Other Notes

Small volumes of LDLR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LDLR purchase

MBS206270 is a recombinant protein targeting LDLR. Also known as LDLR chaperone MESD, 30-224aa, Mouse, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LDLR. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
LRP chaperone MESD
NCBI Official Synonym Full Names
mesoderm development LRP chaperone
NCBI Official Symbol
Mesd
NCBI Official Synonym Symbols
msd; mesd; Mesdc2; AW537813; mKIAA0081; 2210015O11Rik
UniProt Protein Name
LRP chaperone MESD
UniProt Synonym Protein Names
LDLR chaperone MESD; Mesoderm development candidate 2; Mesoderm development protein
UniProt Gene Name
Mesd
NCBI Protein Information
LRP chaperone MESD

UniProt Comments for LDLR

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction (PubMed:12581525). Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (PubMed:24140340). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (PubMed:27184668).
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000