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Interleukin-6 Receptor Subunit Beta (IL6ST) Baculovirus Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206274

IL6st, also known as interleukin-6 receptor subunit beta, is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Interleukin-6 receptor subunit beta (Il6st), Recombinant Protein
Full Product Name
Interleukin-6 receptor subunit beta, 23-617aa, Mouse, His tag, Baculovirus
Product Gene Name
Il6st recombinant protein
Product Synonym Names
Il6st; 5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699e; gp130
Sequence
QLLEPCGYIY PEFPVVQRGS NFTAICVLKE ACLQHYYVNA SYIVWKTNHA AVPREQVTVI NRTTSSVTFT DVVLPSVQLT CNILSFGQIE QNVYGVTMLS GFPPDKPTNL TCIVNEGKNM LCQWDPGRET YLETNYTLKS EWATEKFPDC QSKHGTSCMV SYMPTYYVNI EVWVEAENAL GKVSSESINF DPVDKVKPTP PYNLSVTNSE ELSSILKLSW VSSGLGGLLD LKSDIQYRTK DASTWIQVPL EDTMSPRTSF TVQDLKPFTE YVFRIRSIKD SGKGYWSDWS EEASGTTYED RPSRPPSFWY KTNPSHGQEY RSVRLIWKAL PLSEANGKIL DYEVILTQSK SVSQTYTVTG TELTVNLTND RYVASLAARN KVGKSAAAVL TIPSPHVTAA YSVVNLKAFP KDNLLWVEWT PPPKPVSKYI LEWCVLSENA PCVEDWQQED ATVNRTHLRG RLLESKCYQI TVTPVFATGP GGSESLKAYL KQAAPARGPT VRTKKVGKNE AVLAWDQIPV DDQNGFIRNY SISYRTSVGK EMVVHVDSSH TEYTLSSLSS DTLYMVRMAA YTDEGGKDGP EFTFTTPKFA QGEIELEHHH HHH
Host
Baculovirus
Form/Format
Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
Purity/Purification
> 95% by SDS-PAGE
Concentration
1mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
67.7kDa (603aa) 70-100kDa (SDS-PAGE under reducing conditions)
3D Structure
ModBase 3D Structure for Q00560
Antigen Species
Mouse
Tag Information
His-tag
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for Il6st recombinant protein

Cell Biology; Apoptosis
Applications Tested/Suitable for Il6st recombinant protein
SDS-PAGE

SDS-Page of Il6st recombinant protein

Baculovirus IL6ST Recombinant Protein – Cat# MBS206274

Product References and Citations for Il6st recombinant protein

Saito M., et al. (1992) J Immunol. 148: 4066-4071.; Murakami M., et al. (1993) Science. 260:1808-1810.

Other Notes

Small volumes of Il6st recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Il6st purchase

MBS206274 is a recombinant protein targeting Il6st. Also known as Interleukin-6 receptor subunit beta, 23-617aa, Mouse, His tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for Il6st. It may not necessarily be applicable to this product.

NCBI GI #
225007625
NCBI GeneID
16195
NCBI Accession #
NP_034690
UniProt Primary Accession #
Q00560
UniProt Secondary Accession #
G5E8D2
UniProt Related Accession #
Q00560
GenBank Nucleotide #
NM_010560.3
NCBI Official Full Name
interleukin-6 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 6 signal transducer
NCBI Official Symbol
Il6st
NCBI Official Synonym Symbols
CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik
UniProt Protein Name
Interleukin-6 receptor subunit beta
UniProt Synonym Protein Names
Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
Protein Family
Interleukin-6 receptor
UniProt Gene Name
Il6st
UniProt Synonym Gene Names
IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130
NCBI Protein Information
interleukin-6 receptor subunit beta

UniProt Comments for Il6st

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:1602143). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Does not bind IL6 (). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596).
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Research Articles on Il6st

1. This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Il6st recombinant protein

 Reference Product  PubMed Publications
 Stat3 recombinant protein  >332 publications with Il6st and Stat3
 Lif recombinant protein  >246 publications with Il6st and Lif
 Osm recombinant protein  >184 publications with Il6st and Osm
 Cntf recombinant protein  >117 publications with Il6st and Cntf
 Il11 recombinant protein  >90 publications with Il6st and Il11
 Jak2 recombinant protein  >52 publications with Il6st and Jak2
 Socs3 recombinant protein  >40 publications with Il6st and Socs3
 Il27 recombinant protein  >15 publications with Il6st and Il27
 Il6ra recombinant protein  >1 publications with Il6st and Il6ra

Pathways associated with Il6st recombinant protein

 Products by Pathway  Pathway Diagram
 Adipogenesis Genes Pathway antibodies  Adipogenesis Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 ESC Pluripotency Pathways antibodies  ESC Pluripotency Pathways Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 IL-6-type Cytokine Receptor Ligand Interactions Pathway antibodies  IL-6-type Cytokine Receptor Ligand Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Family Signaling Pathway antibodies  Interleukin-6 Family Signaling Pathway Diagram
 Interleukin-6 Signaling Pathway antibodies  Interleukin-6 Signaling Pathway Diagram

Diseases associated with Il6st recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >139 publications with Il6st and Inflammation
 Carcinoma Antibodies  >70 publications with Il6st and Carcinoma
 Disease Models, Animal Antibodies  >65 publications with Il6st and Disease Models, Animal
 Heart Diseases Antibodies  >51 publications with Il6st and Heart Diseases
 Necrosis Antibodies  >50 publications with Il6st and Necrosis
 Hypertrophy Antibodies  >32 publications with Il6st and Hypertrophy
 Liver Neoplasms Antibodies  >30 publications with Il6st and Liver Neoplasms
 Arthritis, Rheumatoid Antibodies  >26 publications with Il6st and Arthritis, Rheumatoid
 Lung Diseases Antibodies  >23 publications with Il6st and Lung Diseases
 Breast Neoplasms Antibodies  >16 publications with Il6st and Breast Neoplasms

Organs/Tissues associated with Il6st recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >245 publications with Il6st and Blood
 Liver Antibodies  >99 publications with Il6st and Liver
 Bone Antibodies  >93 publications with Il6st and Bone
 Brain Antibodies  >85 publications with Il6st and Brain
 Heart Antibodies  >75 publications with Il6st and Heart
 Bone Marrow Antibodies  >62 publications with Il6st and Bone Marrow
 Lung Antibodies  >39 publications with Il6st and Lung
 Embryonic Tissue Antibodies  >36 publications with Il6st and Embryonic Tissue
 Kidney Antibodies  >22 publications with Il6st and Kidney
 Spleen Antibodies  >19 publications with Il6st and Spleen
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