Baculovirus TIMP1 Recombinant Protein – Cat# MBS206295

Metalloproteinase Inhibitor 1 (TIMP1) Baculovirus Recombinant Protein

Name: TIMP1 Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206295
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206295

TIMP1, also known as metalloproteinase inhibitor 1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group… More details

$230 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Metalloproteinase inhibitor 1 (Timp1), Recombinant Protein

Full Product Name

Metalloproteinase inhibitor 1, 24-217aa, Rat, His tag, Baculovirus

Product Gene Name

Timp1 recombinant protein

Product Synonym Names

Timp1; Timp; TIMP-1

Sequence

CSCAPTHPQT AFCNSDLVIR AKFMGSPEII ETTLYQRYEI KMTKMLKGFD AVGNATGFRF AYTPAMESLC GYVHKSQNRS EEFLIAGRLR NGNLHITACS FLVPWHNLSP AQQKAFVKTY SAGCGVCTVF PCSAIPCKLE SDSHCLWTDQ ILMGSEKGYQ SDHFACLPRN PDLCTWQYLG VSMTRSLPLA KAEAHHHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

22.3kDa (200aa) 18-28KDa (SDS-PAGE under reducing conditions.)

3D Structure

ModBase 3D Structure for P30120

Antigen Species

Rat

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for Timp1 recombinant protein

Enzymes & Proteases; Cardiovascular; Angiogenesis

Applications Tested/Suitable for Timp1 recombinant protein

SDS-PAGE

Product References and Citations for Timp1 recombinant protein

Uchida C et al., (2014) Biochem. Cell Biol. 92 (1):77-83.; Zhang CY et al., (2013) Acta Pharmacol. Sin. 34 (10):1301-1309.

Other Notes

Small volumes of Timp1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Timp1 purchase

MBS206295 is a recombinant protein targeting Timp1. Also known as Metalloproteinase inhibitor 1, 24-217aa, Rat, His tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for Timp1. It may not necessarily be applicable to this product.

NCBI GI #

16758666

NCBI GeneID

116510

NCBI Accession #

NP_446271

UniProt Primary Accession #

P30120

UniProt Secondary Accession #

P70533; Q53YM7

UniProt Related Accession #

P30120

GenBank Nucleotide #

NM_053819.1

NCBI Official Full Name

metalloproteinase inhibitor 1

NCBI Official Synonym Full Names

TIMP metallopeptidase inhibitor 1

NCBI Official Symbol

Timp1

NCBI Official Synonym Symbols

Timp; TIMP-1

UniProt Protein Name

Metalloproteinase inhibitor 1

UniProt Synonym Protein Names

Tissue inhibitor of metalloproteinases 1; TIMP-1

Protein Family

Metalloproteinase inhibitor

UniProt Gene Name

Timp1

UniProt Synonym Gene Names

Timp-1; TIMP-1

NCBI Protein Information

metalloproteinase inhibitor 1

NCBI Summary for Timp1

acts as an inhibitor of metalloprotease activity; may play a role in vascular tissue remodeling [RGD, Feb 2006]

UniProt Comments for Timp1

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.

Research Articles on Timp1

1. Data suggest that increased blood pressure and decreased pup weight in ischemic model of pregnancy-induced hypertension are associated with decrease in Mmp9 homodimer and increase in Mmp9/Timp1 complex in placenta, uterus, and uterine artery; thus Mmp9 and Timp1 appear to be involved in uteroplacental/vascular remodeling in preeclampsia. (Mmp9 = matrix metalloproteinase 9; Timp1 = tissue inhibitor of metalloproteinase-1)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Timp1 recombinant protein

Reference Product	PubMed Publications
Mmp9 recombinant protein	>526 publications with Timp1 and Mmp9
Mmp2 recombinant protein	>413 publications with Timp1 and Mmp2
Mmp3 recombinant protein	>132 publications with Timp1 and Mmp3
Tgfb1 recombinant protein	>127 publications with Timp1 and Tgfb1
Mmp14 recombinant protein	>45 publications with Timp1 and Mmp14
Hgf recombinant protein	>18 publications with Timp1 and Hgf
Igf1 recombinant protein	>12 publications with Timp1 and Igf1
Sparc recombinant protein	>10 publications with Timp1 and Sparc
Mmp1a recombinant protein	>2 publications with Timp1 and Mmp1a

Pathways associated with Timp1 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
HIF-1 Signaling Pathway antibodies	HIF-1 Signaling Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram
Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies	Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with Timp1 recombinant protein

Disease Name	Pubmed Publications
Fibrosis Antibodies	>294 publications with Timp1 and Fibrosis
Inflammation Antibodies	>290 publications with Timp1 and Inflammation
Vascular Diseases Antibodies	>178 publications with Timp1 and Vascular Diseases
Disease Models, Animal Antibodies	>165 publications with Timp1 and Disease Models, Animal
Liver Diseases Antibodies	>162 publications with Timp1 and Liver Diseases
Necrosis Antibodies	>136 publications with Timp1 and Necrosis
Heart Diseases Antibodies	>127 publications with Timp1 and Heart Diseases
Liver Cirrhosis Antibodies	>100 publications with Timp1 and Liver Cirrhosis
Female Urogenital Diseases Antibodies	>97 publications with Timp1 and Female Urogenital Diseases
Neoplasm Invasiveness Antibodies	>90 publications with Timp1 and Neoplasm Invasiveness

Organs/Tissues associated with Timp1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>175 publications with Timp1 and Muscle
Lung Antibodies	>159 publications with Timp1 and Lung
Heart Antibodies	>141 publications with Timp1 and Heart
Connective Tissue Antibodies	>121 publications with Timp1 and Connective Tissue
Artery Antibodies	>107 publications with Timp1 and Artery
Brain Antibodies	>101 publications with Timp1 and Brain
Kidney Antibodies	>99 publications with Timp1 and Kidney
Embryonic Tissue Antibodies	>83 publications with Timp1 and Embryonic Tissue
Eye Antibodies	>43 publications with Timp1 and Eye
Prostate Antibodies	>34 publications with Timp1 and Prostate