Integrin Alpha 8 (ITGa8) Antibody – Rabbit Polyclonal

This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016]

ITGA8: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Belongs to the integrin alpha chain family.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2 A1|2 9.12 cM

Cellular Component: apical part of cell; cell surface; endoplasmic reticulum; focal adhesion; perikaryon; postsynaptic density

Biological Process: cell projection organization and biogenesis; cell-matrix adhesion; establishment of protein localization; extracellular matrix organization and biogenesis; inner ear morphogenesis; kidney development; memory; metanephros development; positive regulation of transforming growth factor beta receptor signaling pathway; smooth muscle development