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Mothers Against Decapentaplegic Homolog 6 (SMAD6) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2063318
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MBS2063318 is an antibody targeting Smad6. Also known as APC/CY7-Linked Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 6 (Smad6). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$445 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Mothers Against Decapentaplegic Homolog 6 (Smad6), Polyclonal Antibody
Full Product Name
APC/CY7-Linked Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 6 (Smad6)
Product Gene Name
anti-Smad6 antibody
Product Synonym Names
MADH6; MADH7
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Concentration
>=100ug/ml (lot specific)
Matching Pairs
Unconjugated Antibody: Smad6 (MBS2026236)
APC-CY7 Conjugated Antibody: Smad6 (MBS2063318)
Matching Pairs
APC-CY7 Conjugated Antibody: Smad6 (MBS2063318)
Immunogen: Smad6 (MBS2031814)
Molecular Weight
35,467 Da
OMIM
U59914 mRNA
3D Structure
ModBase 3D Structure for O43541
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Smad6 (Cys261~Pro495)
Conjugation
APC-Cy7
Cross Reactivity
Human
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2026236
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-Smad6 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

Other Notes

Small volumes of anti-Smad6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Smad6. It may not necessarily be applicable to this product.

NCBI GI #
92859871
NCBI GeneID
4091
NCBI Accession #
NP_005576.3
UniProt Primary Accession #
O43541
UniProt Secondary Accession #
O43654; Q15799; Q7Z7L4; Q96E31; Q9UKZ3; A9J6M5
UniProt Related Accession #
O43541
GenBank Nucleotide #
NM_005585.4
NCBI Official Full Name
mothers against decapentaplegic homolog 6
NCBI Official Synonym Full Names
SMAD family member 6
NCBI Official Symbol
SMAD6
NCBI Official Synonym Symbols
AOVD2; MADH6; MADH7; HsT17432
UniProt Protein Name
Mothers against decapentaplegic homolog 6
UniProt Synonym Protein Names
SMAD family member 6; SMAD 6; Smad6; hSMAD6
Protein Family
Mothers against decapentaplegic
UniProt Gene Name
SMAD6
UniProt Synonym Gene Names
MADH6; MAD homolog 6; Mothers against DPP homolog 6; SMAD 6; Smad6; hSMAD6
NCBI Protein Information
mothers against decapentaplegic homolog 6

NCBI Summary for Smad6

The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]
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UniProt Comments for Smad6

SMAD6: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: cytoplasm; cytosol; nucleus; protein complex

Molecular Function: chromatin binding; identical protein binding; protein binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; ubiquitin protein ligase binding

Biological Process: BMP signaling pathway; cell-substrate adhesion; fat cell differentiation; immune response; negative regulation of apoptosis; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; negative regulation of ossification; negative regulation of transforming growth factor beta receptor signaling pathway; zygotic determination of dorsal/ventral axis

Disease: Aortic Valve Disease 2
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Research Articles on Smad6

1. Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Smad6 antibody

 Reference Product  PubMed Publications
 SMAD1 antibody  >137 publications with Smad6 and SMAD1
 BMP2 antibody  >69 publications with Smad6 and BMP2
 BMPR2 antibody  >32 publications with Smad6 and BMPR2
 BMP7 antibody  >26 publications with Smad6 and BMP7
 SMURF1 antibody  >17 publications with Smad6 and SMURF1
 BMPR1A antibody  >16 publications with Smad6 and BMPR1A
 BMPR1B antibody  >6 publications with Smad6 and BMPR1B
 TGFBR1 antibody  >2 publications with Smad6 and TGFBR1
 ACVR1B antibody  >1 publications with Smad6 and ACVR1B

Pathways associated with anti-Smad6 antibody

 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with anti-Smad6 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >31 publications with Smad6 and Fibrosis
 Lung Diseases Antibodies  >18 publications with Smad6 and Lung Diseases
 Disease Models, Animal Antibodies  >17 publications with Smad6 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >16 publications with Smad6 and Cardiovascular Diseases
 Inflammation Antibodies  >15 publications with Smad6 and Inflammation
 Hypertension Antibodies  >13 publications with Smad6 and Hypertension
 Kidney Diseases Antibodies  >13 publications with Smad6 and Kidney Diseases
 Necrosis Antibodies  >10 publications with Smad6 and Necrosis
 Neoplasms, Experimental Antibodies  >8 publications with Smad6 and Neoplasms, Experimental
 Heart Diseases Antibodies  >8 publications with Smad6 and Heart Diseases

Organs/Tissues associated with anti-Smad6 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >235 publications with Smad6 and Bone
 Embryonic Tissue Antibodies  >32 publications with Smad6 and Embryonic Tissue
 Kidney Antibodies  >23 publications with Smad6 and Kidney
 Heart Antibodies  >22 publications with Smad6 and Heart
 Lung Antibodies  >18 publications with Smad6 and Lung
 Connective Tissue Antibodies  >17 publications with Smad6 and Connective Tissue
 Brain Antibodies  >15 publications with Smad6 and Brain
 Ovary Antibodies  >12 publications with Smad6 and Ovary
 Eye Antibodies  >9 publications with Smad6 and Eye
 Parathyroid Antibodies  >8 publications with Smad6 and Parathyroid
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