Baculovirus PLAU Recombinant Protein – Cat# MBS206389

3 ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

PLAU Baculovirus Recombinant Protein

Name: PLAU Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206389
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206389

PLAU, also known as urokinase-type plasminogen activator, is a serine protease which converts plasminogen to plasmin. It is a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in complement activation, cell migration,… More details

$265 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PLAU, Recombinant Protein

Full Product Name

PLAU, 21-431aa, Human, His tag, Baculovirus

Product Gene Name

PLAU recombinant protein

Product Synonym Names

Urokinase-type plasminogen activator; PLAU; ATF; BDPLT5; QPD; u-PA; UPA; URK; Endothelial plasminogen activator inhibitor; PAI PAI 1; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator urinary; Plasminogen activator urokinase; Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; Serpin E1; Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; SERPINE1; u PA; U plasminogen activator; UPA; URK; Urokinase type plasminogen activator

Sequence

SNELHQVPSN CDCLNGGTCV SNKYFSNIHW CNCPKKFGGQ HCEIDKSKTC YEGNGHFYRG KASTDTMGRP CLPWNSATVL QQTYHAHRSD ALQLGLGKHN YCRNPDNRRR PWCYVQVGLK PLVQECMVHD CADGKKPSSP PEELKFQCGQ KTLRPRFKII GGEFTTIENQ PWFAAIYRRH RGGSVTYVCG GSLISPCWVI SATHCFIDYP KKEDYIVYLG RSRLNSNTQG EMKFEVENLI LHKDYSADTL AHHNDIALLK IRSKEGRCAQ PSRTIQTICL PSMYNDPQFG TSCEITGFGK ENSTDYLYPE QLKMTVVKLI SHRECQQPHY YGSEVTTKML CAADPQWKTD SCQGDSGGPL VCSLQGRMTL TGIVSWGRGC ALKDKPGVYT RVSHFLPWIR SHTKEENGLA LLEHHHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 2°C to 8°C for 1 week.
For long term storage, aliquot and store at -20°C to -80°C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

47.4 kDa (419aa)

OMIM

M15476 mRNA

3D Structure

ModBase 3D Structure for P00749

Tag Information

His-tag

Domain

21-431aa

Endotoxin Level

< 1.0 EU per 1 ug of protein (determined by LAL method)

Product Categories/Family for PLAU recombinant protein

Enzymes & Proteases; Neuroscience

Applications Tested/Suitable for PLAU recombinant protein

SDS-PAGE

Product References and Citations for PLAU recombinant protein

Crippa MP., et al. (2007) Int J Biochem Cell Biol. 39:690-694.; Kunamneni A., et al. (2008) Recent Pat Cardiovasc Drug Discov. 3:45-58.

Other Notes

Small volumes of PLAU recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLAU purchase

MBS206389 is a recombinant protein targeting PLAU. Also known as PLAU, 21-431aa, Human, His tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for PLAU. It may not necessarily be applicable to this product.

NCBI GI #

4505863

NCBI GeneID

5328

NCBI Accession #

NP_002649

UniProt Primary Accession #

P00749

UniProt Secondary Accession #

Q15844; Q16618; Q53XS3; Q5SWW9; Q969W6; B4DPZ2

UniProt Related Accession #

P00749

GenBank Nucleotide #

NM_002658.4

NCBI Official Full Name

urokinase-type plasminogen activator isoform 1 preproprotein

NCBI Official Synonym Full Names

plasminogen activator, urokinase

NCBI Official Symbol

PLAU

NCBI Official Synonym Symbols

ATF; QPD; UPA; URK; u-PA; BDPLT5

UniProt Protein Name

Urokinase-type plasminogen activator

Protein Family

Urokinase-type plasminogen activator

UniProt Gene Name

PLAU

UniProt Synonym Gene Names

U-plasminogen activator; uPA

NCBI Protein Information

urokinase-type plasminogen activator

NCBI Summary for PLAU

This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

UniProt Comments for PLAU

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

Research Articles on PLAU

1. Gelsolin enhances the invasive capacity of colon cancer cells via elevating intracellular superoxide (O2.-) levels by interacting with Cu/ZnSOD, and gelsolin gene expression positively correlates with urokinase plasminogen activator (uPA), an important matrix-degrading protease invovled in cancer invasion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLAU recombinant protein

Reference Product	PubMed Publications
PLAUR recombinant protein	>25 publications with PLAU and PLAUR
MMP9 recombinant protein	>19 publications with PLAU and MMP9
SERPINE1 recombinant protein	>15 publications with PLAU and SERPINE1
EGFR recombinant protein	>7 publications with PLAU and EGFR
SERPINE2 recombinant protein	>5 publications with PLAU and SERPINE2
SERPINB2 recombinant protein	>4 publications with PLAU and SERPINB2
FOS recombinant protein	>3 publications with PLAU and FOS
VLDLR recombinant protein	>1 publications with PLAU and VLDLR
VTN recombinant protein	>1 publications with PLAU and VTN
MAPK1 recombinant protein	>1 publications with PLAU and MAPK1

Pathways associated with PLAU recombinant protein

Products by Pathway	Pathway Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
Blood Clotting Cascade Pathway antibodies	Blood Clotting Cascade Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
DNA Damage Response (only ATM Dependent) Pathway antibodies	DNA Damage Response (only ATM Dependent) Pathway Diagram
Dissolution Of Fibrin Clot Pathway antibodies	Dissolution Of Fibrin Clot Pathway Diagram
E2F Transcription Factor Network Pathway antibodies	E2F Transcription Factor Network Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram
FGF Signaling Pathway antibodies	FGF Signaling Pathway Diagram

Diseases associated with PLAU recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>31 publications with PLAU and Inflammation
Adenocarcinoma Antibodies	>22 publications with PLAU and Adenocarcinoma
Alzheimer Disease Antibodies	>16 publications with PLAU and Alzheimer Disease
Neoplasm Invasiveness Antibodies	>14 publications with PLAU and Neoplasm Invasiveness
Prostatic Neoplasms Antibodies	>12 publications with PLAU and Prostatic Neoplasms
Neoplasm Metastasis Antibodies	>12 publications with PLAU and Neoplasm Metastasis
Stomach Neoplasms Antibodies	>7 publications with PLAU and Stomach Neoplasms
Pancreatic Neoplasms Antibodies	>5 publications with PLAU and Pancreatic Neoplasms
Quebec platelet disorder Antibodies	>5 publications with PLAU and Quebec platelet disorder
Hemorrhage Antibodies	>4 publications with PLAU and Hemorrhage

Organs/Tissues associated with PLAU recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>48 publications with PLAU and Blood
Lung Antibodies	>21 publications with PLAU and Lung
Vascular Antibodies	>20 publications with PLAU and Vascular
Brain Antibodies	>16 publications with PLAU and Brain
Bone Antibodies	>15 publications with PLAU and Bone
Prostate Antibodies	>14 publications with PLAU and Prostate
Skin Antibodies	>11 publications with PLAU and Skin
Placenta Antibodies	>10 publications with PLAU and Placenta
Thyroid Antibodies	>9 publications with PLAU and Thyroid
Stomach Antibodies	>8 publications with PLAU and Stomach