Baculovirus PGC Recombinant Protein – Cat# MBS206391

PGC Baculovirus Recombinant Protein

Name: PGC Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206391
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206391

PGC, also known as gastricsin, is an aspartic proteinase that belongs to the peptidase family A1. It is synthesized in the gastric mucosa as inactive precursors. It contains a prosegment that serves to stabilize the inactive form and prevent entry of the… More details

$230 / 0.004 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PGC, Recombinant Protein

Full Product Name

PGC, 17-388aa, Human, His tag, Baculovirus

Product Gene Name

PGC recombinant protein

Product Synonym Names

Gastricsin; PGC; PEPC; PGII; Gastricsin; PEPC_HUMAN; pepsin C; Pepsinogen C; pepsinogen group II; PGII; preprogastricsin; Progastricsin

Sequence

AVVKVPLKKF KSIRETMKEK GLLGEFLRTH KYDPAWKYRF GDLSVTYEPM AYMDAAYFGE ISIGTPPQNF LVLFDTGSSN LWVPSVYCQS QACTSHSRFN PSESSTYSTN GQTFSLQYGS GSLTGFFGYD TLTVQSIQVP NQEFGLSENE PGTNFVYAQF DGIMGLAYPA LSVDEATTAM QGMVQEGALT SPVFSVYLSN QQGSSGGAVV FGGVDSSLYT GQIYWAPVTQ ELYWQIGIEE FLIGGQASGW CSEGCQAIVD TGTSLLTVPQ QYMSALLQAT GAQEDEYGQF LVNCNSIQNL PSLTFIINGV EFPLPPSSYI LSNNGYCTVG VEPTYLSSQN GQPLWILGDV FLRSYYSVYD LGNNRVGFAT AALEHHHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.25mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

41.6kDa (380aa) 40-57kDa (SDS-PAGE under reducing conditions)

3D Structure

ModBase 3D Structure for P20142

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for PGC recombinant protein

Epigenomics (Transcription & Translation)

Applications Tested/Suitable for PGC recombinant protein

SDS-PAGE

Product References and Citations for PGC recombinant protein

Richter C., et al. (1998) Biochem J. 335:481-490.; Westerveld BD., et al. (1987) Gastroenterology. 93:774-778.

Other Notes

Small volumes of PGC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGC purchase

MBS206391 is a recombinant protein targeting PGC. Also known as PGC, 17-388aa, Human, His tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for PGC. It may not necessarily be applicable to this product.

NCBI GI #

4505757

NCBI GeneID

5225

NCBI Accession #

NP_002621

UniProt Primary Accession #

P20142

UniProt Secondary Accession #

Q5T3D7; Q5T3D8; B4DVZ3

UniProt Related Accession #

P20142

GenBank Nucleotide #

NM_002630.3

NCBI Official Full Name

gastricsin isoform 1 preproprotein

NCBI Official Synonym Full Names

progastricsin

NCBI Official Symbol

PGC

NCBI Official Synonym Symbols

PEPC; PGII

UniProt Protein Name

Gastricsin

UniProt Synonym Protein Names

Pepsinogen C

Protein Family

Gastricsin

UniProt Gene Name

PGC

NCBI Protein Information

gastricsin

NCBI Summary for PGC

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

UniProt Comments for PGC

Hydrolyzes a variety of proteins.

Research Articles on PGC

1. serum levels correlated with age, sex and the level of Helicobacter pylori infection

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PGC recombinant protein

Reference Product	PubMed Publications
PGD recombinant protein	>9 publications with PGC and PGD

Diseases associated with PGC recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>341 publications with PGC and Inflammation
Fatty Liver Antibodies	>262 publications with PGC and Fatty Liver
Heart Diseases Antibodies	>230 publications with PGC and Heart Diseases
Liver Diseases Antibodies	>226 publications with PGC and Liver Diseases
Atrophy Antibodies	>171 publications with PGC and Atrophy
Necrosis Antibodies	>170 publications with PGC and Necrosis
Hypertrophy Antibodies	>169 publications with PGC and Hypertrophy
Kidney Diseases Antibodies	>125 publications with PGC and Kidney Diseases
Weight Loss Antibodies	>93 publications with PGC and Weight Loss
Fibrosis Antibodies	>77 publications with PGC and Fibrosis

Organs/Tissues associated with PGC recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>738 publications with PGC and Liver
Heart Antibodies	>538 publications with PGC and Heart
Brain Antibodies	>506 publications with PGC and Brain
Connective Tissue Antibodies	>308 publications with PGC and Connective Tissue
Stomach Antibodies	>106 publications with PGC and Stomach
Lung Antibodies	>70 publications with PGC and Lung
Pancreas Antibodies	>64 publications with PGC and Pancreas
Prostate Antibodies	>19 publications with PGC and Prostate
Esophagus Antibodies	>7 publications with PGC and Esophagus
Uncharacterized Tissue Antibodies	>2 publications with PGC and Uncharacterized Tissue