Baculovirus IDS Recombinant Protein – Cat# MBS206469

IDS Baculovirus Recombinant Protein

Name: IDS Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206469
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206469

IDS, as known as iduronate 2-sulfatase isoform, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O-sulfate and N-salfate esters from a varity of substrates. This protein is required for the lysosomal degradation… More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IDS, Recombinant Protein

Full Product Name

IDS, 26-550aa, Human, His-tag, Baculovirus

Product Gene Name

IDS recombinant protein

Product Synonym Names

Iduronate 2-sulfatase isoform; IDS; MPS2; SIDS

Sequence

SETQANSTTD ALNVLLIIVD DLRPSLGCYG DKLVRSPNID QLASHSLLFQ NAFAQQAVCA PSRVSFLTGR RPDTTRLYDF NSYWRVHAGN FSTIPQYFKE NGYVTMSVGK VFHPGISSNH TDDSPYSWSF PPYHPSSEKY ENTKTCRGPD GELHANLLCP VDVLDVPEGT LPDKQSTEQA IQLLEKMKTS ASPFFLAVGY HKPHIPFRYP KEFQKLYPLE NITLAPDPEV PDGLPPVAYN PWMDIRQRED VQALNISVPY GPIPVDFQRK IRQSYFASVS YLDTQVGRLL SALDDLQLAN STIIAFTSDH GWALGEHGEW AKYSNFDVAT HVPLIFYVPG RTASLPEAGE KLFPYLDPFD SASQLMEPGR QSMDLVELVS LFPTLAGLAG LQVPPRCPVP SFHVELCREG KNLLKHFRFR DLEEDPYLPG NPRELIAYSQ YPRPSDIPQW NSDKPSLKDI KIMGYSIRTI DYRYTVWVGF NPDEFLANFS DIHAGELYFV DSDPLQDHNM YNDSQGGDLF QLLMPLEHHH HHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.25mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

60.3kDa (533aa) 50-70kDa (SDS-PAGE under reducing conditions.)

OMIM

M58342 mRNA

3D Structure

ModBase 3D Structure for P22304

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for IDS recombinant protein

Enzymes & Proteases

Applications Tested/Suitable for IDS recombinant protein

SDS-PAGE

Product References and Citations for IDS recombinant protein

Torres LC., et al, (2014) Clin. Immunol. 154:100-104.; Chistiakov DA., et al, (2014) J. Genet. Genomics. 41:197-203.

Other Notes

Small volumes of IDS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IDS purchase

MBS206469 is a recombinant protein targeting IDS. Also known as IDS, 26-550aa, Human, His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for IDS. It may not necessarily be applicable to this product.

NCBI GI #

4557659

NCBI GeneID

3423

NCBI Accession #

NP_000193

UniProt Primary Accession #

P22304

UniProt Secondary Accession #

Q14604; Q9BRM3; D3DWT4

UniProt Related Accession #

P22304

GenBank Nucleotide #

NM_000202.7

NCBI Official Full Name

iduronate 2-sulfatase isoform a preproprotein

NCBI Official Synonym Full Names

iduronate 2-sulfatase

NCBI Official Symbol

IDS

NCBI Official Synonym Symbols

MPS2; SIDS

UniProt Protein Name

Iduronate 2-sulfatase

UniProt Synonym Protein Names

Alpha-L-iduronate sulfate sulfatase; Idursulfase

Protein Family

Iduronate 2-sulfatase

UniProt Gene Name

IDS

UniProt Synonym Gene Names

SIDS; Idursulfase

NCBI Protein Information

iduronate 2-sulfatase

NCBI Summary for IDS

This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

UniProt Comments for IDS

Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

Research Articles on IDS

1. Study analyzed the genotype-phenotype relationship for 17 patients with mucopolysaccharidosis II and performed expression studies for 12 variants, nine of which have not been reported previously; speculated that very low or cell-type-specific IDS residual activity is sufficient to prevent the neuronal phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IDS recombinant protein

Reference Product	PubMed Publications
IDUA recombinant protein	>9 publications with IDS and IDUA
AFF2 recombinant protein	>5 publications with IDS and AFF2
ARSJ recombinant protein	>1 publications with IDS and ARSJ
GNS recombinant protein	>1 publications with IDS and GNS
SUMF1 recombinant protein	>1 publications with IDS and SUMF1
HPSE recombinant protein	>1 publications with IDS and HPSE

Pathways associated with IDS recombinant protein

Products by Pathway	Pathway Diagram
CS/DS Degradation Pathway antibodies	CS/DS Degradation Pathway Diagram
Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies	Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
Dermatan Sulfate Degradation Pathway antibodies	Dermatan Sulfate Degradation Pathway Diagram
Dermatan Sulfate Degradation Pathway antibodies	Dermatan Sulfate Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
HS-GAG Degradation Pathway antibodies	HS-GAG Degradation Pathway Diagram
Heparan Sulfate Degradation Pathway antibodies	Heparan Sulfate Degradation Pathway Diagram
Heparan Sulfate Degradation Pathway antibodies	Heparan Sulfate Degradation Pathway Diagram

Diseases associated with IDS recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>486 publications with IDS and Nervous System Diseases
Mucopolysaccharidosis II Antibodies	>241 publications with IDS and Mucopolysaccharidosis II
Brain Diseases Antibodies	>79 publications with IDS and Brain Diseases
Inflammation Antibodies	>67 publications with IDS and Inflammation
Congenital Abnormalities Antibodies	>56 publications with IDS and Congenital Abnormalities
Heart Diseases Antibodies	>54 publications with IDS and Heart Diseases
Disease Models, Animal Antibodies	>54 publications with IDS and Disease Models, Animal
Kidney Diseases Antibodies	>45 publications with IDS and Kidney Diseases
Liver Diseases Antibodies	>36 publications with IDS and Liver Diseases
Adenocarcinoma Antibodies	>36 publications with IDS and Adenocarcinoma

Organs/Tissues associated with IDS recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>459 publications with IDS and Blood
Brain Antibodies	>162 publications with IDS and Brain
Bone Antibodies	>126 publications with IDS and Bone
Heart Antibodies	>103 publications with IDS and Heart
Muscle Antibodies	>79 publications with IDS and Muscle
Liver Antibodies	>71 publications with IDS and Liver
Vascular Antibodies	>63 publications with IDS and Vascular
Kidney Antibodies	>58 publications with IDS and Kidney
Skin Antibodies	>50 publications with IDS and Skin
Mouth Antibodies	>48 publications with IDS and Mouth