Baculovirus CD68 Recombinant Protein – Cat# MBS206491

CD68 Baculovirus Recombinant Protein

Name: CD68 Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206491
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206491

CD68, also known as macrosialin, is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. It is expressed on monocytes/macrophages. It is found in cytoplasmic granules and in the cytoplasm of various non-hematopoietic tissues… More details

$230 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD68, Recombinant Protein

Full Product Name

CD68, 22-319aa, Human, His-tag, Baculovirus

Product Gene Name

CD68 recombinant protein

Product Synonym Names

Macrosialin isoform A; CD68; GP110; LAMP4; SCARD1

Sequence

ADPNDCPHKK SATLLPSFTV TPTVTESTGT TSHRTTKSHK TTTHRTTTTG TTSHGPTTAT HNPTTTSHGN VTVHPTSNST ATSQGPSTAT HSPATTSHGN ATVHPTSNST ATSPGFTSSA HPEPPPPSPS PSPTSKETIG DYTWTNGSQP CVHLQAQIQI RVMYTTQGGG EAWGISVLNP NKTKVQGSCE GAHPHLLLSF PYGHLSFGFM QDLQQKVVYL SYMAVEYNVS FPHAAQWTFS AQNASLRDLQ APLGQSFSCS NSSIILSPAV HLDLLSLRLQ AAQLPHTGVF GQSFSCPSDR SHHHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 95% by SDS-PAGE

Concentration

1mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

32.6kDa (307aa) 57-70KDa (SDS-PAGE under reducing conditions.)

OMIM

S57235 mRNA

3D Structure

ModBase 3D Structure for P34810

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for CD68 recombinant protein

Immunology

Applications Tested/Suitable for CD68 recombinant protein

SDS-PAGE

Product References and Citations for CD68 recombinant protein

Strobl H. et al., (1995) Br. J. Haematol. 90:774-782.; Ogawa Y. et al., (1995) Pathol. Int. 45:698-701.

Other Notes

Small volumes of CD68 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD68 purchase

MBS206491 is a recombinant protein targeting CD68. Also known as CD68, 22-319aa, Human, His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CD68. It may not necessarily be applicable to this product.

NCBI GI #

91199548

NCBI GeneID

968

NCBI Accession #

NP_001242

UniProt Primary Accession #

P34810

UniProt Secondary Accession #

Q53HR6; Q53XI3; Q96BI7; B4DVT4

UniProt Related Accession #

P34810

GenBank Nucleotide #

NM_001251.2

NCBI Official Full Name

macrosialin isoform A

NCBI Official Synonym Full Names

CD68 molecule

NCBI Official Symbol

CD68

NCBI Official Synonym Symbols

GP110; LAMP4; SCARD1

UniProt Protein Name

Macrosialin

UniProt Synonym Protein Names

Gp110; CD_antigen: CD68

Protein Family

Macrosialin

UniProt Gene Name

CD68

NCBI Protein Information

macrosialin

NCBI Summary for CD68

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for CD68

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Research Articles on CD68

1. Taken together, these results suggested that the changes, including ox-LDL/LDL ratio, CD68(+)/RANK(+) cells number, and the levels of RANKL and HMGB1 in AS patients, favored osteoclastogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD68 recombinant protein

Reference Product	PubMed Publications
CD34 recombinant protein	>714 publications with CD68 and CD34
CD163 recombinant protein	>703 publications with CD68 and CD163
TNF recombinant protein	>692 publications with CD68 and TNF
CCL2 recombinant protein	>336 publications with CD68 and CCL2
IL6 recombinant protein	>84 publications with CD68 and IL6
PTPRC recombinant protein	>38 publications with CD68 and PTPRC
ITGAM recombinant protein	>22 publications with CD68 and ITGAM
VIM recombinant protein	>10 publications with CD68 and VIM
ITGAX recombinant protein	>4 publications with CD68 and ITGAX

Pathways associated with CD68 recombinant protein

Products by Pathway	Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Neutrophil Degranulation Pathway antibodies	Neutrophil Degranulation Pathway Diagram

Diseases associated with CD68 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>2378 publications with CD68 and Inflammation
Necrosis Antibodies	>1148 publications with CD68 and Necrosis
Disease Models, Animal Antibodies	>776 publications with CD68 and Disease Models, Animal
Fibrosis Antibodies	>671 publications with CD68 and Fibrosis
Lung Diseases Antibodies	>541 publications with CD68 and Lung Diseases
Atherosclerosis Antibodies	>481 publications with CD68 and Atherosclerosis
Kidney Diseases Antibodies	>481 publications with CD68 and Kidney Diseases
Liver Diseases Antibodies	>443 publications with CD68 and Liver Diseases
Heart Diseases Antibodies	>382 publications with CD68 and Heart Diseases
Hyperplasia Antibodies	>268 publications with CD68 and Hyperplasia

Organs/Tissues associated with CD68 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>3552 publications with CD68 and Blood
Vascular Antibodies	>1743 publications with CD68 and Vascular
Muscle Antibodies	>1325 publications with CD68 and Muscle
Bone Antibodies	>1103 publications with CD68 and Bone
Skin Antibodies	>1096 publications with CD68 and Skin
Brain Antibodies	>1083 publications with CD68 and Brain
Liver Antibodies	>762 publications with CD68 and Liver
Lymph Node Antibodies	>648 publications with CD68 and Lymph Node
Kidney Antibodies	>638 publications with CD68 and Kidney
Lung Antibodies	>629 publications with CD68 and Lung