Baculovirus IL23 Recombinant Protein – Cat# MBS206648

IL23 Baculovirus Recombinant Protein

Name: IL23 Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206648
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206648

IL23 p40&p19, also known as interleukin-12 subunit beta/interleukin-23 subunit alpha, is a heterodimeric cytokine composed of two disulfide-linked subunit, a p19 subunit that is unique to IL23, and a p40 subunit that is shared with IL12. The p19 subunit has… More details

$230 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL23, Recombinant Protein

Full Product Name

IL23 23-328aa (IL12B) / 20-189aa (IL23A), Human, His-tag, Baculovirus

Product Gene Name

IL23 recombinant protein

Product Synonym Names

Interleukin-12 subunit beta / Interleukin-23 subunit alpha; CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2/ IL-23; IL-23A; IL23P19; P19; SGRF

Sequence

>IL12B: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS
>IL23A: RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP HHHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

34.6kDa (IL12B) & 19.5kDa (IL23A) (306aa & 176aa)

OMIM

M65272 mRNA

3D Structure

ModBase 3D Structure for P29460

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for IL23 recombinant protein

Immunology; Hormones & Cytokines

Applications Tested/Suitable for IL23 recombinant protein

SDS-PAGE

Product References and Citations for IL23 recombinant protein

Oppmann B., et al, (2000) Immunity. 13:715-25.; Parham C., et al, (2002) J. lmmunol. 168:5699-708.

Other Notes

Small volumes of IL23 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL23 purchase

MBS206648 is a recombinant protein targeting IL23. Also known as IL23 23-328aa (IL12B) / 20-189aa (IL23A), Human, His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for IL23. It may not necessarily be applicable to this product.

NCBI GI #

24497438

NCBI GeneID

3593

NCBI Accession #

NP_002178

NCBI Related Accession #

NP_057668

UniProt Primary Accession #

P29460

UniProt Related Accession #

P29460

GenBank Nucleotide #

NM_002187.2

NCBI Official Full Name

interleukin-12 subunit beta

NCBI Official Synonym Full Names

interleukin 12B

NCBI Official Symbol

IL12B

NCBI Official Synonym Symbols

CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B

UniProt Protein Name

Interleukin-12 subunit beta

UniProt Synonym Protein Names

Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2

UniProt Gene Name

IL12B

UniProt Synonym Gene Names

NKSF2; IL-12B; CLMF p40; NKSF2

NCBI Protein Information

interleukin-12 subunit beta

NCBI Summary for IL23

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

UniProt Comments for IL23

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Research Articles on IL23

1. The anti-EGFR viroplexes with IL-12 and salmosin genes exhibited the most effective therapeutic efficacy in a mouse tumor model, especially when combined with doxorubicin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL23 recombinant protein

Reference Product	PubMed Publications
IL23R recombinant protein	>97 publications with IL23 and IL23R
IL12A recombinant protein	>77 publications with IL23 and IL12A
IL6 recombinant protein	>64 publications with IL23 and IL6
IL4 recombinant protein	>52 publications with IL23 and IL4
IL12RB1 recombinant protein	>51 publications with IL23 and IL12RB1
IFNG recombinant protein	>45 publications with IL23 and IFNG
IL23A recombinant protein	>41 publications with IL23 and IL23A
STAT1 recombinant protein	>29 publications with IL23 and STAT1
IL12RB2 recombinant protein	>16 publications with IL23 and IL12RB2
STAT4 recombinant protein	>12 publications with IL23 and STAT4

Pathways associated with IL23 recombinant protein

Products by Pathway	Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Aryl Hydrocarbon Receptor Pathway antibodies	Aryl Hydrocarbon Receptor Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram

Diseases associated with IL23 recombinant protein

Disease Name	Pubmed Publications
Psoriasis Antibodies	>94 publications with IL23 and Psoriasis
Inflammation Antibodies	>90 publications with IL23 and Inflammation
Necrosis Antibodies	>65 publications with IL23 and Necrosis
Crohn Disease Antibodies	>38 publications with IL23 and Crohn Disease
Lung Diseases Antibodies	>37 publications with IL23 and Lung Diseases
Arthritis, Psoriatic Antibodies	>31 publications with IL23 and Arthritis, Psoriatic
Liver Diseases Antibodies	>30 publications with IL23 and Liver Diseases
Colitis, Ulcerative Antibodies	>27 publications with IL23 and Colitis, Ulcerative
Disease Models, Animal Antibodies	>24 publications with IL23 and Disease Models, Animal
Spondylitis, Ankylosing Antibodies	>12 publications with IL23 and Spondylitis, Ankylosing

Organs/Tissues associated with IL23 recombinant protein

Organ/Tissue Name	Pubmed Publications
Mixed Antibodies	>7 publications with IL23 and Mixed