Baculovirus CD28 Active Protein – Cat# MBS206653

CD28 Baculovirus Active Protein

Name: CD28 Active Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206653
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206653

CD28, also known as T-cell-specific surface glycoprotein CD28 isoform 1, is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell… More details

$230 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD28, Active Protein

Full Product Name

CD28, 19-152aa, Human, hIgG-His-tag, Baculovirus

Product Gene Name

CD28 active protein

Product Synonym Names

T-cell-specific surface glycoprotein CD28 isoform 1; CD28; Tp44

Sequence

ADPNKILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPLEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 90% by SDS-PAGE

Concentration

1mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

42.4kDa (376aa) 40-57kDa (SDS-PAGE under reducing conditions)

OMIM

J02988 mRNA

3D Structure

ModBase 3D Structure for P10747

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Antigen Species

Human

Tag Information

hIgG-His-tag

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Product Categories/Family for CD28 active protein

Immunology

Applications Tested/Suitable for CD28 active protein

SDS-PAGE

Product References and Citations for CD28 active protein

Prasad KV., et al. (1994) National Academy. 91: 2834 -2838.; Okkenhaug K., et al. (1998) J. Biol. Chem. 273: 21194 -21202.

Other Notes

Small volumes of CD28 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD28 purchase

MBS206653 is an active protein targeting CD28. Also known as CD28, 19-152aa, Human, hIgG-His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CD28. It may not necessarily be applicable to this product.

NCBI GI #

5453611

NCBI GeneID

940

NCBI Accession #

NP_006130

UniProt Primary Accession #

P10747

UniProt Secondary Accession #

Q13964; Q52M23; Q70WG0; Q8NI54; Q8NI55; Q8NI56; Q8WXJ2; Q9BYV0; A8KAC1

UniProt Related Accession #

P10747

GenBank Nucleotide #

NM_006139.3

NCBI Official Full Name

T-cell-specific surface glycoprotein CD28 isoform 1

NCBI Official Synonym Full Names

CD28 molecule

NCBI Official Symbol

CD28

NCBI Official Synonym Symbols

Tp44

UniProt Protein Name

T-cell-specific surface glycoprotein CD28

UniProt Synonym Protein Names

TP44; CD_antigen: CD28

Protein Family

T-cell-specific surface glycoprotein

UniProt Gene Name

CD28

NCBI Protein Information

T-cell-specific surface glycoprotein CD28

NCBI Summary for CD28

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

UniProt Comments for CD28

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

Research Articles on CD28

1. These preliminary results suggest that patients undergoing liver or kidney transplant can be stratified at high risk of EAR according to their CD28 molecule expression on peripheral CD4(+) T lymphocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD28 active protein

Reference Product	PubMed Publications
CD80 active protein	>2041 publications with CD28 and CD80
CD86 active protein	>1346 publications with CD28 and CD86
CD2 active protein	>517 publications with CD28 and CD2
LCK active protein	>187 publications with CD28 and LCK
VAV1 active protein	>65 publications with CD28 and VAV1
ITK active protein	>49 publications with CD28 and ITK
GRAP2 active protein	>7 publications with CD28 and GRAP2
CD247 active protein	>1 publications with CD28 and CD247

Pathways associated with CD28 active protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
CD28 Co-stimulation Pathway antibodies	CD28 Co-stimulation Pathway Diagram
CD28 Dependent PI3K/Akt Signaling Pathway antibodies	CD28 Dependent PI3K/Akt Signaling Pathway Diagram
CD28 Dependent Vav1 Pathway antibodies	CD28 Dependent Vav1 Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with CD28 active protein

Disease Name	Pubmed Publications
Autoimmune Diseases Antibodies	>1412 publications with CD28 and Autoimmune Diseases
Necrosis Antibodies	>1107 publications with CD28 and Necrosis
Inflammation Antibodies	>997 publications with CD28 and Inflammation
HIV Infections Antibodies	>490 publications with CD28 and HIV Infections
Arthritis, Rheumatoid Antibodies	>410 publications with CD28 and Arthritis, Rheumatoid
Cardiovascular Diseases Antibodies	>374 publications with CD28 and Cardiovascular Diseases
Lung Diseases Antibodies	>367 publications with CD28 and Lung Diseases
Lymphoma Antibodies	>358 publications with CD28 and Lymphoma
Vascular Diseases Antibodies	>342 publications with CD28 and Vascular Diseases
Carcinoma Antibodies	>283 publications with CD28 and Carcinoma

Organs/Tissues associated with CD28 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>9089 publications with CD28 and Blood
Thymus Antibodies	>363 publications with CD28 and Thymus
Brain Antibodies	>157 publications with CD28 and Brain
Embryonic Tissue Antibodies	>56 publications with CD28 and Embryonic Tissue
Pharynx Antibodies	>36 publications with CD28 and Pharynx
Connective Tissue Antibodies	>33 publications with CD28 and Connective Tissue
Placenta Antibodies	>21 publications with CD28 and Placenta
Uterus Antibodies	>20 publications with CD28 and Uterus
Adipose Tissue Antibodies	>14 publications with CD28 and Adipose Tissue
Trachea Antibodies	>13 publications with CD28 and Trachea