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L1CAM Baculovirus Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206668

L1CAM, also known as neural cell adhesion molecule L1 isoform 3, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. It is now recognized to play a key role in cell migration, adhesion, neurite outgrowth,… More details

$230 / 0.01 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
L1CAM, Recombinant Protein
Full Product Name
L1CAM, 20-1115aa, Human, His-tag, Baculovirus
Product Gene Name
L1CAM recombinant protein
Product Synonym Names
Neural cell adhesion molecule L1 isoform 3; L1CAM; CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1
Sequence
IQIPEELMEP PVITEQSPRR LVVFPTDDIS LKCEASGKPE VQFRWTRDGV HFKPKEELGV TVYQSPHSGS FTITGNNSNF AQRFQGIYRC FASNKLGTAM SHEIRLMAEG APKWPKETVK PVEVEEGESV VLPCNPPPSA EPLRIYWMNS KILHIKQDER VTMGQNGNLY FANVLTSDNH SDYICHAHFP GTRTIIQKEP IDLRVKATNS MIDRKPRLLF PTNSSSHLVA LQGQPLVLEC IAEGFPTPTI KWLRPSGPMP ADRVTYQNHN KTLQLLKVGE EDDGEYRCLA ENSLGSARHA YYVTVEAAPY WLHKPQSHLY GPGETARLDC QVQGRPQPEV TWRINGIPVE ELAKDQKYRI QRGALILSNV QPSDTMVTQC EARNRHGLLL ANAYIYVVQL PAKILTADNQ TYMAVQGSTA YLLCKAFGAP VPSVQWLDED GTTVLQDERF FPYANGTLGI RDLQANDTGR YFCLAANDQN NVTIMANLKV KDATQITQGP RSTIEKKGSR VTFTCQASFD PSLQPSITWR GDGRDLQELG DSDKYFIEDG RLVIHSLDYS DQGNYSCVAS TELDVVESRA QLLVVGSPGP VPRLVLSDLH LLTQSQVRVS WSPAEDHNAP IEKYDIEFED KEMAPEKWYS LGKVPGNQTS TTLKLSPYVH YTFRVTAINK YGPGEPSPVS ETVVTPEAAP EKNPVDVKGE GNETTNMVIT WKPLRWMDWN APQVQYRVQW RPQGTRGPWQ EQIVSDPFLV VSNTSTFVPY EIKVQAVNSQ GKGPEPQVTI GYSGEDYPQA IPELEGIEIL NSSAVLVKWR PVDLAQVKGH LRGYNVTYWR EGSQRKHSKR HIHKDHVVVP ANTTSVILSG LRPYSSYHLE VQAFNGRGSG PASEFTFSTP EGVPGHPEAL HLECQSNTSL LLRWQPPLSH NGVLTGYVLS YHPLDEGGKG QLSFNLRDPE LRTHNLTDLS PHLRYRFQLQ ATTKEGPGEA IVREGGTMAL SGISDFGNIS ATAGENYSVV SWVPKEGQCN FRFHILFKAL GEEKGGASLS PQYVSYNQSS YTQWDLQPDT DYEIHLFKER MFRHQMAVKT NGTGRVRLPP AGFATELEHH HHHH
Host
Baculovirus
Form/Format
Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.25mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
123.6kDa (1104aa) 100-150kDa (SDS-PAGE under reducing conditions)
OMIM
X59847 mRNA
3D Structure
ModBase 3D Structure for P32004
Antigen Species
Human
Tag Information
His-tag
Endotoxin Level
< 1.0 EU per 1ug of protein (determined by LAL method)

Product Categories/Family for L1CAM recombinant protein

Signal Transduction; Hormones & Cytokines; Adhesion & Movement
Applications Tested/Suitable for L1CAM recombinant protein
SDS-PAGE

SDS-Page of L1CAM recombinant protein

Baculovirus L1CAM Recombinant Protein – Cat# MBS206668

Product References and Citations for L1CAM recombinant protein

Maness, P.F., et al. (2007) Nat. Neurosci. 10:19-26.; Gavert, N., et al. (2008) Expert Opin Biol Ther. 8 (11):1749-57.

Other Notes

Small volumes of L1CAM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L1CAM purchase

MBS206668 is a recombinant protein targeting L1CAM. Also known as L1CAM, 20-1115aa, Human, His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for L1CAM. It may not necessarily be applicable to this product.

NCBI GI #
221316760
NCBI GeneID
3897
NCBI Accession #
NP_001137435
UniProt Primary Accession #
P32004
UniProt Secondary Accession #
Q8TA87; A0AV65; A4ZYW4; B2RMU7; G3XAF4
UniProt Related Accession #
P32004
GenBank Nucleotide #
NM_001143963.2
NCBI Official Full Name
neural cell adhesion molecule L1 isoform 3
NCBI Official Synonym Full Names
L1 cell adhesion molecule
NCBI Official Symbol
L1CAM
NCBI Official Synonym Symbols
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
UniProt Protein Name
Neural cell adhesion molecule L1
UniProt Synonym Protein Names
CD_antigen: CD171
Protein Family
Neural cell adhesion molecule
UniProt Gene Name
L1CAM
UniProt Synonym Gene Names
CAML1; MIC5; N-CAM-L1; NCAM-L1
NCBI Protein Information
neural cell adhesion molecule L1

NCBI Summary for L1CAM

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
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UniProt Comments for L1CAM

Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
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Research Articles on L1CAM

1. Our preclinical assessment of the CE7 epitope on CD171 supports its utility and safety as a CAR T-cell target for neuroblastoma immunotherapy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with L1CAM recombinant protein

 Reference Product  PubMed Publications
 CNTN2 recombinant protein  >16 publications with L1CAM and CNTN2
 EGFR recombinant protein  >14 publications with L1CAM and EGFR
 NCAM1 recombinant protein  >13 publications with L1CAM and NCAM1
 NCAN recombinant protein  >10 publications with L1CAM and NCAN
 ANK2 recombinant protein  >8 publications with L1CAM and ANK2
 NRP1 recombinant protein  >7 publications with L1CAM and NRP1
 RANBP9 recombinant protein  >1 publications with L1CAM and RANBP9
 ANK1 recombinant protein  >1 publications with L1CAM and ANK1

Pathways associated with L1CAM recombinant protein

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram

Diseases associated with L1CAM recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >390 publications with L1CAM and Nervous System Diseases
 Brain Diseases Antibodies  >244 publications with L1CAM and Brain Diseases
 Disease Models, Animal Antibodies  >95 publications with L1CAM and Disease Models, Animal
 Adenocarcinoma Antibodies  >67 publications with L1CAM and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >55 publications with L1CAM and Ovarian Neoplasms
 Abnormalities, Multiple Antibodies  >41 publications with L1CAM and Abnormalities, Multiple
 Neoplasms, Experimental Antibodies  >31 publications with L1CAM and Neoplasms, Experimental
 Aphasia Antibodies  >30 publications with L1CAM and Aphasia
 Nerve Degeneration Antibodies  >25 publications with L1CAM and Nerve Degeneration
 Lung Neoplasms Antibodies  >24 publications with L1CAM and Lung Neoplasms

Organs/Tissues associated with L1CAM recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >913 publications with L1CAM and Brain
 Nerve Antibodies  >469 publications with L1CAM and Nerve
 Embryonic Tissue Antibodies  >118 publications with L1CAM and Embryonic Tissue
 Ganglia Antibodies  >69 publications with L1CAM and Ganglia
 Eye Antibodies  >64 publications with L1CAM and Eye
 Muscle Antibodies  >53 publications with L1CAM and Muscle
 Kidney Antibodies  >43 publications with L1CAM and Kidney
 Skin Antibodies  >40 publications with L1CAM and Skin
 Lung Antibodies  >38 publications with L1CAM and Lung
 Liver Antibodies  >38 publications with L1CAM and Liver
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