Baculovirus SIGLEC7 Recombinant Protein – Cat# MBS206687

SIGLEC7 Baculovirus Recombinant Protein

Name: SIGLEC7 Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206687
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206687

SIGLEC7, also known as sialic acid-binding Ig-like lectin 7 isoform 1, is a recently discovered family of sialic acid-binding lectins of the immunoglobulin (Ig) superfamily. The extracellular portion has two Ig-like domains, with the amino-terminal V-set Ig… More details

$230 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SIGLEC7, Recombinant Protein

Full Product Name

SIGLEC7, 19-353aa, Human, hIgG-His-tag, Baculovirus

Product Gene Name

SIGLEC7 recombinant protein

Product Synonym Names

Sialic acid-binding Ig-like lectin 7 isoform 1; SIGLEC7; AIRM1; CD328; CDw328; D-siglec; p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2

Sequence

ADPQKSNRKD YSLTMQSSVT VQEGMCVHVR CSFSYPVDSQ TDSDPVHGYW FRAGNDISWK APVATNNPAW AVQEETRDRF HLLGDPQTKN CTLSIRDARM SDAGRYFFRM EKGNIKWNYK YDQLSVNVTA LTHRPNILIP GTLESGCFQN LTCSVPWACE QGTPPMISWM GTSVSPLHPS TTRSSVLTLI PQPQHHGTSL TCQVTLPGAG VTTNRTIQLN VSYPPQNLTV TVFQGEGTAS TALGNSSSLS VLEGQSLRLV CAVDSNPPAR LSWTWRSLTL YPSQPSNPLV LELQVHLGDE GEFTCRAQNS LGSQHVSLNL SLQQEYTGKM RPVSGVLLLE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

64.2kDa (577aa) 70-100kDa (SDS-PAGE under reducing conditions)

OMIM

AF170485 mRNA

3D Structure

ModBase 3D Structure for Q9Y286

Antigen Species

Human

Tag Information

hIgG-His-tag

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Product Categories/Family for SIGLEC7 recombinant protein

Cardiovascular; Other

Applications Tested/Suitable for SIGLEC7 recombinant protein

SDS-PAGE

Product References and Citations for SIGLEC7 recombinant protein

Crocker., et al. (2001) Trends Immunol. 22:337-342.; Nicoll G., et al. (1999) J. Biol. Chem. 274:34089-34095.

Other Notes

Small volumes of SIGLEC7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIGLEC7 purchase

MBS206687 is a recombinant protein targeting SIGLEC7. Also known as SIGLEC7, 19-353aa, Human, hIgG-His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for SIGLEC7. It may not necessarily be applicable to this product.

NCBI GI #

7657570

NCBI GeneID

27036

NCBI Accession #

NP_055200

UniProt Primary Accession #

Q9Y286

UniProt Secondary Accession #

Q9NZQ1; Q9UJ86; Q9UJ87; Q9Y502

UniProt Related Accession #

Q9Y286

GenBank Nucleotide #

NM_014385.3

NCBI Official Full Name

sialic acid-binding Ig-like lectin 7 isoform 1

NCBI Official Synonym Full Names

sialic acid binding Ig like lectin 7

NCBI Official Symbol

SIGLEC7

NCBI Official Synonym Symbols

p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1

UniProt Protein Name

Sialic acid-binding Ig-like lectin 7

UniProt Synonym Protein Names

Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD_antigen: CD328

Protein Family

Sialic acid-binding Ig-like lectin

UniProt Gene Name

SIGLEC7

UniProt Synonym Gene Names

AIRM1; Siglec-7; AIRM-1

NCBI Protein Information

sialic acid-binding Ig-like lectin 7

UniProt Comments for SIGLEC7

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Research Articles on SIGLEC7

1. Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SIGLEC7 recombinant protein

Reference Product	PubMed Publications
PTPN11 recombinant protein	>3 publications with SIGLEC7 and PTPN11
SYK recombinant protein	>1 publications with SIGLEC7 and SYK
ZAP70 recombinant protein	>1 publications with SIGLEC7 and ZAP70

Pathways associated with SIGLEC7 recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with SIGLEC7 recombinant protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>8 publications with SIGLEC7 and Immune System Diseases
Inflammation Antibodies	>7 publications with SIGLEC7 and Inflammation
Kidney Diseases Antibodies	>5 publications with SIGLEC7 and Kidney Diseases
Colorectal Neoplasms Antibodies	>2 publications with SIGLEC7 and Colorectal Neoplasms
Lung Neoplasms Antibodies	>2 publications with SIGLEC7 and Lung Neoplasms
Nervous System Diseases Antibodies	>2 publications with SIGLEC7 and Nervous System Diseases
Necrosis Antibodies	>2 publications with SIGLEC7 and Necrosis
Acute Kidney Injury Antibodies	>1 publications with SIGLEC7 and Acute Kidney Injury
Renal Insufficiency Antibodies	>1 publications with SIGLEC7 and Renal Insufficiency
Peripheral Nervous System Diseases Antibodies	>1 publications with SIGLEC7 and Peripheral Nervous System Diseases

Organs/Tissues associated with SIGLEC7 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>40 publications with SIGLEC7 and Blood
Liver Antibodies	>4 publications with SIGLEC7 and Liver
Spleen Antibodies	>2 publications with SIGLEC7 and Spleen
Adrenal Gland Antibodies	>1 publications with SIGLEC7 and Adrenal Gland