Baculovirus PVR Recombinant Protein – Cat# MBS206694

PVR Baculovirus Recombinant Protein

Name: PVR Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206694
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206694

PVR, also known as poliovirus receptor isoform alpha, is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. It catalyzes a large structural change in the virus that exposes membrane-binding protein chains. It plays an important regulatory… More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PVR, Recombinant Protein

Full Product Name

PVR, 21-343aa, Human, His-tag, Baculovirus

Product Gene Name

PVR recombinant protein

Product Synonym Names

Poliovirus receptor isoform alpha; PVR; CD155; HVED; Necl-5; NECL5; PVS; TAGE4

Sequence

WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGM SRNLEHHHHH H

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 90% by SDS-PAGE

Concentration

1mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

36.1kDa (331aa) 40-57kDa (SDS-PAGE under reducing conditions)

OMIM

M24407 mRNA

3D Structure

ModBase 3D Structure for P15151

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Product Categories/Family for PVR recombinant protein

Neuroscience; Adhesion & Movement

Applications Tested/Suitable for PVR recombinant protein

SDS-PAGE

Product References and Citations for PVR recombinant protein

Nishiwada S., et al. (2015) Anticancer Res. 35:2287-2297.; Strauss M., et al. (2015) J Virol. 89:4143-4157.

Other Notes

Small volumes of PVR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PVR purchase

MBS206694 is a recombinant protein targeting PVR. Also known as PVR, 21-343aa, Human, His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for PVR. It may not necessarily be applicable to this product.

NCBI GI #

609878250

NCBI GeneID

5817

NCBI Accession #

NP_006496

UniProt Primary Accession #

P15151

UniProt Secondary Accession #

P15152; Q15267; Q15268; Q96BJ1; B4DTS9

UniProt Related Accession #

P15151

GenBank Nucleotide #

NM_006505.4

NCBI Official Full Name

poliovirus receptor isoform alpha

NCBI Official Synonym Full Names

poliovirus receptor

NCBI Official Symbol

PVR

NCBI Official Synonym Symbols

PVS; HVED; CD155; NECL5; TAGE4; Necl-5

UniProt Protein Name

Poliovirus receptor

UniProt Synonym Protein Names

Nectin-like protein 5; NECL-5; CD_antigen: CD155

Protein Family

Poliovirus receptor

UniProt Gene Name

PVR

UniProt Synonym Gene Names

PVS; NECL-5

NCBI Protein Information

poliovirus receptor

NCBI Summary for PVR

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

UniProt Comments for PVR

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.

Research Articles on PVR

1. The authors demonstrate that HIV and specifically Nef and/or Vpu do not modulate CD155 on infected primary T cells and both CD155 and NKG2D ligands synergize as a natural killer cell receptor to trigger natural killer cell lysis of the infected cell.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PVR recombinant protein

Reference Product	PubMed Publications
PVRL1 recombinant protein	>33 publications with PVR and PVRL1
CD226 recombinant protein	>28 publications with PVR and CD226
TIGIT recombinant protein	>15 publications with PVR and TIGIT
SRC recombinant protein	>12 publications with PVR and SRC
CD96 recombinant protein	>7 publications with PVR and CD96
PVRL3 recombinant protein	>3 publications with PVR and PVRL3

Pathways associated with PVR recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Adherens Junctions Interactions Pathway antibodies	Adherens Junctions Interactions Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-cell Junction Organization Pathway antibodies	Cell-cell Junction Organization Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Nectin Adhesion Pathway antibodies	Nectin Adhesion Pathway Diagram

Diseases associated with PVR recombinant protein

Disease Name	Pubmed Publications
Hypertension Antibodies	>1275 publications with PVR and Hypertension
Lung Diseases Antibodies	>1133 publications with PVR and Lung Diseases
Heart Diseases Antibodies	>897 publications with PVR and Heart Diseases
Hyperplasia Antibodies	>492 publications with PVR and Hyperplasia
Disease Models, Animal Antibodies	>306 publications with PVR and Disease Models, Animal
Death Antibodies	>243 publications with PVR and Death
Inflammation Antibodies	>180 publications with PVR and Inflammation
Edema Antibodies	>140 publications with PVR and Edema
Fibrosis Antibodies	>116 publications with PVR and Fibrosis
Hypertrophy Antibodies	>104 publications with PVR and Hypertrophy

Organs/Tissues associated with PVR recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>2452 publications with PVR and Vascular
Blood Antibodies	>1851 publications with PVR and Blood
Heart Antibodies	>1580 publications with PVR and Heart
Eye Antibodies	>1059 publications with PVR and Eye
Lung Antibodies	>902 publications with PVR and Lung
Bladder Antibodies	>565 publications with PVR and Bladder
Prostate Antibodies	>563 publications with PVR and Prostate
Muscle Antibodies	>305 publications with PVR and Muscle
Brain Antibodies	>168 publications with PVR and Brain
Liver Antibodies	>143 publications with PVR and Liver