Baculovirus MME Recombinant Protein – Cat# MBS206696

MME Baculovirus Recombinant Protein

Name: MME Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206696
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206696

MME, also known as neprilysin, is a zinc metallopeptidase expressed at the cell surface of a variety of cells. It degrades the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's… More details

$230 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MME, Recombinant Protein

Full Product Name

MME, 52-750aa, Human, His-tag, Baculovirus

Product Gene Name

MME recombinant protein

Product Synonym Names

Neprilysin; MME; CALLA; CD10; CMT2T; NEP; SCA43; SFE

Sequence

ADPYDDGICK SSDCIKSAAR LIQNMDATTE PCTDFFKYAC GGWLKRNVIP ETSSRYGNFD ILRDELEVVL KDVLQEPKTE DIVAVQKAKA LYRSCINESA IDSRGGEPLL KLLPDIYGWP VATENWEQKY GASWTAEKAI AQLNSKYGKK VLINLFVGTD DKNSVNHVIH IDQPRLGLPS RDYYECTGIY KEACTAYVDF MISVARLIRQ EERLPIDENQ LALEMNKVME LEKEIANATA KPEDRNDPML LYNKMTLAQI QNNFSLEING KPFSWLNFTN EIMSTVNISI TNEEDVVVYA PEYLTKLKPI LTKYSARDLQ NLMSWRFIMD LVSSLSRTYK ESRNAFRKAL YGTTSETATW RRCANYVNGN MENAVGRLYV EAAFAGESKH VVEDLIAQIR EVFIQTLDDL TWMDAETKKR AEEKALAIKE RIGYPDDIVS NDNKLNNEYL ELNYKEDEYF ENIIQNLKFS QSKQLKKLRE KVDKDEWISG AAVVNAFYSS GRNQIVFPAG ILQPPFFSAQ QSNSLNYGGI GMVIGHEITH GFDDNGRNFN KDGDLVDWWT QQSASNFKEQ SQCMVYQYGN FSWDLAGGQH LNGINTLGEN IADNGGLGQA YRAYQNYIKK NGEEKLLPGL DLNHKQLFFL NFAQVWCGTY RPEYAVNSIK TDVHSPGNFR IIGTLQNSAE FSEAFHCRKN SYMNPEKKCR VWHHHHHH

Host

Baculovirus

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 100mM NaCl, 0.1mM PMSF, 10% glycerol.

Purity/Purification

> 95% by SDS-PAGE

Concentration

1mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

80.9kDa (708aa) 70-100kDa (SDS-PAGE under reducing conditions)

OMIM

Y00811 mRNA

3D Structure

ModBase 3D Structure for P08473

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Product Categories/Family for MME recombinant protein

Cardiovascular; Angiogenesis; Adhesion & Movement

Applications Tested/Suitable for MME recombinant protein

SDS-PAGE

Product References and Citations for MME recombinant protein

Auer-Grumbach M., et al. (2016) Am J Hum Genet. 99:607-623.; Hama E., et al. (2005) Med Hypotheses. 65:498-500.

Other Notes

Small volumes of MME recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MME purchase

MBS206696 is a recombinant protein targeting MME. Also known as MME, 52-750aa, Human, His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for MME. It may not necessarily be applicable to this product.

NCBI GI #

116256329

NCBI GeneID

4311

NCBI Accession #

NP_000893

UniProt Primary Accession #

P08473

UniProt Secondary Accession #

Q3MIX4; A8K6U6; D3DNJ9

UniProt Related Accession #

P08473

GenBank Nucleotide #

NM_000902.3

NCBI Official Full Name

neprilysin isoform a

NCBI Official Synonym Full Names

membrane metalloendopeptidase

NCBI Official Symbol

MME

NCBI Official Synonym Symbols

NEP; SFE; CD10; CALLA; CMT2T; SCA43

UniProt Protein Name

Neprilysin

UniProt Synonym Protein Names

Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD_antigen: CD10

Protein Family

Neprilysin

UniProt Gene Name

MME

UniProt Synonym Gene Names

EPN; CALLA; NEP; Neutral endopeptidase; SFE

NCBI Protein Information

neprilysin

NCBI Summary for MME

The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]

UniProt Comments for MME

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

Research Articles on MME

1. In this meta-analysis of the Han Chinese population, neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese populations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MME recombinant protein

Reference Product	PubMed Publications
BCL6 recombinant protein	>4 publications with MME and BCL6
ACE2 recombinant protein	>3 publications with MME and ACE2
AGT recombinant protein	>2 publications with MME and AGT
PRCP recombinant protein	>1 publications with MME and PRCP

Pathways associated with MME recombinant protein

Products by Pathway	Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimers Disease Pathway antibodies	Alzheimers Disease Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies	Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Neutrophil Degranulation Pathway antibodies	Neutrophil Degranulation Pathway Diagram

Diseases associated with MME recombinant protein

Disease Name	Pubmed Publications
Pain Antibodies	>32 publications with MME and Pain
Heart Diseases Antibodies	>18 publications with MME and Heart Diseases
Kidney Diseases Antibodies	>16 publications with MME and Kidney Diseases
Edema Antibodies	>14 publications with MME and Edema
Inflammation Antibodies	>13 publications with MME and Inflammation
Necrosis Antibodies	>13 publications with MME and Necrosis
Neoplasms, Experimental Antibodies	>10 publications with MME and Neoplasms, Experimental
Lung Neoplasms Antibodies	>10 publications with MME and Lung Neoplasms
Hypertension Antibodies	>8 publications with MME and Hypertension
Breast Neoplasms Antibodies	>7 publications with MME and Breast Neoplasms

Organs/Tissues associated with MME recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>80 publications with MME and Blood
Brain Antibodies	>36 publications with MME and Brain
Heart Antibodies	>27 publications with MME and Heart
Lung Antibodies	>27 publications with MME and Lung
Muscle Antibodies	>23 publications with MME and Muscle
Liver Antibodies	>22 publications with MME and Liver
Kidney Antibodies	>21 publications with MME and Kidney
Bone Antibodies	>19 publications with MME and Bone
Eye Antibodies	>16 publications with MME and Eye
Connective Tissue Antibodies	>14 publications with MME and Connective Tissue